Michael Aaron Morse, MD

Professor of Medicine
Professor in the Department of Surgery
Member of the Duke Cancer Institute
Campus mail Duke Box 3233, Durham, NC 27710
Phone (919) 681-3480
Email address morse004@mc.duke.edu

We are studying the use of immune therapies to treat various cancers, including gastrointestinal, breast, and lung cancers and melanoma. These therapies include vaccines based on dendritic cells developed in our laboratory as well as vaccines based on peptides, viral vectors, and DNA plasmids. Our group is also a national leader in the development and use of laboratory assays for demonstrating immunologic responses to cancer vaccines. Finally, we are developing immunotherapies based on adoptive transfer of tumor and viral antigen-specific T cells.

Our current clinical trials include phase I and II studies of immunotherapy for: patients with metastatic malignancies expressing CEA, pancreatic cancer, colorectal cancer, breast cancer, and ovarian cancer, and leukemias following HSCT. My clinical area of expertise is in gastrointestinal oncology, in particular, the treatment of hepatic malignancies, and malignant melanoma.

Key words: dendritic cells, immunotherapy, vaccines, T cells, gastrointestinal oncology, melanoma, hepatoma

Education and Training

  • Fellow in Hematology-Oncology, Medicine, Duke University, 1993 - 1996
  • Medical Resident, Medicine, University of Washington, 1990 - 1993
  • M.D., Yale University, 1990

Grants

Publications

Clary, B. M., E. C. Coveney, D. G. Blazer, R. Philip, M. Philip, M. Morse, E. Gilboa, and H. K. Lyerly. “Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system.” J Immunother 20, no. 1 (January 1997): 26–37. https://doi.org/10.1097/00002371-199701000-00003.

PMID
9101411
Full Text

Morse, M. A., and D. L. Rutlen. “Influence of nitroglycerin on splanchnic capacity and splanchnic capacity-cardiac output relationship.” J Appl Physiol (1985) 76, no. 1 (January 1994): 112–19. https://doi.org/10.1152/jappl.1994.76.1.112.

PMID
8175494
Full Text

Morse, M. A., L. Bell, and D. L. Rutlen. “Influence of splanchnic intravascular volume changes on cardiac output during muscarinic receptor stimulation in the anaesthetized dog.” Acta Physiol Scand 138, no. 3 (March 1990): 331–36. https://doi.org/10.1111/j.1748-1716.1990.tb08854.x.

PMID
2327262
Full Text

Pages