Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Bailey, Jessica N Cooke, Puya Gharahkhani, Jae H. Kang, Mariusz Butkiewicz, David A. Sullivan, Robert N. Weinreb, Hugues Aschard, et al. “Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.” Invest Ophthalmol Vis Sci 59, no. 2 (February 1, 2018): 629–36. https://doi.org/10.1167/iovs.17-22708.

PMID
29392307
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Carnes, Megan Ulmer, R Rand Allingham, Allison Ashley-Koch, and Michael A. Hauser. “Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing.” Exp Eye Res 167 (February 2018): 91–99. https://doi.org/10.1016/j.exer.2016.11.021.

PMID
27914989
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King, Rebecca, Felix L. Struebing, Ying Li, Jiaxing Wang, Allison Ashley Koch, Jessica N. Cooke Bailey, Puya Gharahkhani, et al. “Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.” Plos Genet 14, no. 1 (January 2018): e1007145. https://doi.org/10.1371/journal.pgen.1007145.

PMID
29370175
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Morey, Rajendra A., Sarah L. Davis, Melanie E. Garrett, Courtney C. Haswell, Courtney C. Mid-Atlantic MIRECC Workgroup, Christine E. Marx, Jean C. Beckham, Gregory McCarthy, Michael A. Hauser, and Allison E. Ashley-Koch. “Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls.” Transl Psychiatry 7, no. 11 (November 30, 2017): 1265. https://doi.org/10.1038/s41398-017-0021-6.

PMID
29187748
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Polimanti, Renato, Ananda B. Amstadter, Murray B. Stein, Lynn M. Almli, Dewleen G. Baker, Laura J. Bierut, Bekh Bradley, et al. “A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.” Genome Med 9, no. 1 (November 27, 2017): 99. https://doi.org/10.1186/s13073-017-0491-4.

PMID
29178946
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Chintalapudi, Sumana R., Doaa Maria, Xiang Di Wang, Jessica N Cooke Bailey, Jessica N Cooke NEIGHBORHOOD consortium, Jessica N Cooke International Glaucoma Genetics consortium, Pirro G. Hysi, Janey L. Wiggs, Robert W. Williams, and Monica M. Jablonski. “Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.” Nat Commun 8, no. 1 (November 24, 2017): 1755. https://doi.org/10.1038/s41467-017-00837-5.

PMID
29176626
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Teotia, Pooja, Matthew J. Van Hook, Christopher S. Wichman, R Rand Allingham, Michael A. Hauser, and Iqbal Ahmad. “Modeling Glaucoma: Retinal Ganglion Cells Generated from Induced Pluripotent Stem Cells of Patients with SIX6 Risk Allele Show Developmental Abnormalities.” Stem Cells 35, no. 11 (November 2017): 2239–52. https://doi.org/10.1002/stem.2675.

PMID
28792678
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Aschard, Hugues, Jae H. Kang, Adriana I. Iglesias, Pirro Hysi, Jessica N. Cooke Bailey, Anthony P. Khawaja, R Rand Allingham, et al. “Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.” Eur J Hum Genet 25, no. 11 (November 2017): 1261–67. https://doi.org/10.1038/ejhg.2017.136.

PMID
28853718
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Ratanatharathorn, Andrew, Marco P. Boks, Adam X. Maihofer, Allison E. Aiello, Ananda B. Amstadter, Allison E. Ashley-Koch, Dewleen G. Baker, et al. “Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline.” Am J Med Genet B Neuropsychiatr Genet 174, no. 6 (September 2017): 619–30. https://doi.org/10.1002/ajmg.b.32568.

PMID
28691784
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Aung, Tin, Mineo Ozaki, Mei Chin Lee, Ursula Schlötzer-Schrehardt, Gudmar Thorleifsson, Takanori Mizoguchi, Robert P. Igo, et al. “Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.” Nat Genet 49, no. 7 (July 2017): 993–1004. https://doi.org/10.1038/ng.3875.

PMID
28553957
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Pages