Michael Arthur Hauser, PhD

Professor in Medicine
Associate Research Professor in Molecular Genetics and Microbiology
Member of Duke Molecular Physiology Institute
Campus mail 2016 Genome Science Research Bldg I, Durham, NC 27710
Phone (919) 684-3508
Email address mike.hauser@duke.edu

Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing. 

Education and Training

  • Ph.D., Johns Hopkins University, 1990

Publications

Khor, Chiea Chuen, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, Khaled Abu-Amero, Roopam Duvesh, et al. “Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.” Nat Genet 48, no. 5 (May 2016): 556–62. https://doi.org/10.1038/ng.3540.

PMID
27064256
Full Text

Fritsche, Lars G., Wilmar Igl, Jessica N Cooke Bailey, Felix Grassmann, Sebanti Sengupta, Jennifer L. Bragg-Gresham, Kathryn P. Burdon, et al. “A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.” Nat Genet 48, no. 2 (February 2016): 134–43. https://doi.org/10.1038/ng.3448.

PMID
26691988
Full Text

Bailey, Jessica N Cooke, Stephanie J. Loomis, Jae H. Kang, R Rand Allingham, Puya Gharahkhani, Chiea Chuen Khor, Kathryn P. Burdon, et al. “Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.” Nat Genet 48, no. 2 (February 2016): 189–94. https://doi.org/10.1038/ng.3482.

PMID
26752265
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Hauser, Michael A., Inas F. Aboobakar, Yutao Liu, Shiroh Miura, Benjamin T. Whigham, Pratap Challa, Joshua Wheeler, et al. “Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.” Hum Mol Genet 24, no. 22 (November 15, 2015): 6552–63. https://doi.org/10.1093/hmg/ddv347.

PMID
26307087
Full Text

Cai, Jingwen, Kristin M. Perkumas, Xuejun Qin, Michael A. Hauser, W Daniel Stamer, and Yutao Liu. “Expression Profiling of Human Schlemm's Canal Endothelial Cells From Eyes With and Without Glaucoma.” Invest Ophthalmol Vis Sci 56, no. 11 (October 2015): 6747–53. https://doi.org/10.1167/iovs.15-17720.

PMID
26567786
Full Text

Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Yutao Liu, Ilyas Patanam, Va Mid-Atlantic Mirecc Workgroup, Allison E. Ashley-Koch, Michael A. Hauser, and Jean C. Beckham. “Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.” Psychiatry Res 229, no. 1–2 (September 30, 2015): 326–31. https://doi.org/10.1016/j.psychres.2015.07.002.

PMID
26184988
Full Text

Ashley-Koch, Allison E., Melanie E. Garrett, Jason Gibson, Yutao Liu, Michelle F. Dennis, Nathan A. Kimbrel, Nathan A. Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Jean C. Beckham, and Michael A. Hauser. “Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.” J Affect Disord 184 (September 15, 2015): 225–34. https://doi.org/10.1016/j.jad.2015.03.049.

PMID
26114229
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Li, Zheng, R Rand Allingham, Masakazu Nakano, Liyun Jia, Yuhong Chen, Yoko Ikeda, Baskaran Mani, et al. “A common variant near TGFBR3 is associated with primary open angle glaucoma.” Hum Mol Genet 24, no. 13 (July 1, 2015): 3880–92. https://doi.org/10.1093/hmg/ddv128.

PMID
25861811
Full Text

Abu-Amero, Khaled K., Inas Helwa, Abdulrahman Al-Muammar, Shelby Strickland, Michael A. Hauser, R Rand Allingham, and Yutao Liu. “Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population.” J Negat Results Biomed 14 (June 4, 2015): 10. https://doi.org/10.1186/s12952-015-0029-5.

PMID
26040312
Full Text

King, Rebecca, Michael A. Hauser, Louis R. Pasquale, Janey L. Wiggs, Allison E. Ashley-Koch, R Rand Allingham, and Eldon E. Geisert. “Mouse Genomic Loci Modulating Corneal Thickness.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Pages