Michael August Blazing, MD

Associate Professor of Medicine
Campus mail 7412HOSP North, Durham, NC 27710
Phone (919) 681-3945
Email address blazi001@mc.duke.edu

General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

In Their Words

Education and Training

  • M.D., University of California, San Francisco, School of Medicine, 1987

Publications

Murphy, Sabina A., Christopher P. Cannon, Michael A. Blazing, Robert P. Giugliano, Andrew M. Tershakovec, and Eugene Braunwald. “Reply: Personalize and Optimize Lipid-Lowering Therapies..” J Am Coll Cardiol 68, no. 3 (July 19, 2016). https://doi.org/10.1016/j.jacc.2016.04.043.

PMID
27417014
Full Text

Murphy, Sabina A., Christopher P. Cannon, Michael A. Blazing, Robert P. Giugliano, Andrew M. Tershakovec, and Eugene Braunwald. “Reply: Adding Ezetimibe to Simvastatin for the Secondary Prevention of Cardiovascular Disease: Is it Useful?.” J Am Coll Cardiol 67, no. 25 (June 28, 2016): 3025–26. https://doi.org/10.1016/j.jacc.2016.03.580.

PMID
27339506
Full Text

Nissen, Steven E., Erik Stroes, Ricardo E. Dent-Acosta, Robert S. Rosenson, Sam J. Lehman, Naveed Sattar, David Preiss, et al. “Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial..” Jama 315, no. 15 (April 19, 2016): 1580–90. https://doi.org/10.1001/jama.2016.3608.

PMID
27039291
Full Text

Bohula, Erin A., Robert P. Giugliano, Christopher P. Cannon, Jing Zhou, Sabina A. Murphy, Jennifer White, Andrew M. Tershakovec, Michael A. Blazing, and Eugene Braunwald. “Response to Letter Regarding Article, "Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE-IT"..” Circulation 133, no. 13 (March 29, 2016). https://doi.org/10.1161/CIRCULATIONAHA.116.020947.

PMID
27022050
Full Text

Murphy, Sabina A., Christopher P. Cannon, Michael A. Blazing, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Craig Reist, et al. “Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial..” J Am Coll Cardiol 67, no. 4 (February 2, 2016): 353–61. https://doi.org/10.1016/j.jacc.2015.10.077.

PMID
26821621
Full Text

Cannon, Christopher P., Michael A. Blazing, and Eugene Braunwald. “Ezetimibe plus a Statin after Acute Coronary Syndromes..” N Engl J Med 373, no. 15 (October 8, 2015): 1476–77. https://doi.org/10.1056/NEJMc1509363.

PMID
26444734
Full Text

Bohula, Erin A., Robert P. Giugliano, Christopher P. Cannon, Jing Zhou, Sabina A. Murphy, Jennifer A. White, Andrew M. Tershakovec, Michael A. Blazing, and Eugene Braunwald. “Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT..” Circulation 132, no. 13 (September 29, 2015): 1224–33. https://doi.org/10.1161/CIRCULATIONAHA.115.018381.

PMID
26330412
Full Text

Tricoci, Pierluigi, Denise M. D’Andrea, Paul A. Gurbel, Zhenling Yao, Marina Cuchel, Brion Winston, Robert Schott, et al. “Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial..” J Am Heart Assoc 4, no. 8 (August 25, 2015). https://doi.org/10.1161/JAHA.115.002171.

PMID
26307570
Full Text

Cannon, Christopher P., Michael A. Blazing, Robert P. Giugliano, Amy McCagg, Jennifer A. White, Pierre Theroux, Harald Darius, et al. “Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes..” N Engl J Med 372, no. 25 (June 18, 2015): 2387–97. https://doi.org/10.1056/NEJMoa1410489.

PMID
26039521
Full Text

Cholesterol Treatment Trialists’ (CTT) Collaboration, Anthony, Jordan Fulcher, Rachel O’Connell, Merryn Voysey, Jonathan Emberson, Lisa Blackwell, Borislava Mihaylova, et al. “Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials..” Lancet 385, no. 9976 (April 11, 2015): 1397–1405. https://doi.org/10.1016/S0140-6736(14)61368-4.

PMID
25579834
Full Text

Pages