Michael M. Frank, MD

Professor Emeritus of Pediatrics
Samuel L. Katz Professor of Pediatrics, in the School of Medicine
Professor of Immunology
Professor of Medicine
Campus mail 131 MSRB, Durham, NC 27710
Phone (919) 684-2922
Email address frank007@mc.duke.edu

The research of Dr. Frank's laboratory revolves around effector mechanisms of immune damage. Specifically, the laboratory is interested in understanding how antibody and complement contribute to the damage of tissues and micro-organisms. Overlapping areas of interest include the role of mediators in inflammation and the functions of antibody and complement in the production of autoimmune disease. Specific interests of the group in the last year have included studies of the mechanism by which infusion of intravenous immunoglobulin into animals and man down regulates immunologic damage. A second area of interest concerns the role of complement and antibody in the pathogenesis of HIV and in prevention of HIV infection. A third area concerns the role of complement in the generation of an immune response. A long term interest has been in the clinical signs and appropriate treatment of patients with hereditary angioedema.

Education and Training

  • M.D., Harvard University, 1960

Publications

Busse, P, Baker, J, Martinez-Saguer, I, Bernstein, JA, Craig, T, Magerl, M, Riedl, M, Shapiro, R, Frank, M, Lumry, W, Rosch, J, Edelman, J, Williams-Herman, D, Feuersenger, H, Rojavin, M, and Berinert Registry Investigators, . "Safety of C1-inhibitor concentrate use for hereditary angioedema in pediatric patients." The journal of allergy and clinical immunology. In practice 5, no. 4 (July 2017): 1142-1145.

PMID
28286153
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Frank, MM, Zuraw, B, Banerji, A, Bernstein, JA, Craig, T, Busse, P, Christiansen, S, Davis-Lorton, M, Li, HH, Lumry, WR, Riedl, M, and US Hereditary Angioedema Association Medical Advisory Board, . "Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency." Pediatrics 138, no. 5 (November 2016).

PMID
27940765
Scholars@Duke

Khandelwal, S, Lee, GM, Hester, CG, Poncz, M, McKenzie, SE, Sachais, BS, Rauova, L, Kelsoe, G, Cines, DB, Frank, M, and Arepally, GM. "The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)." Blood 128, no. 14 (October 2016): 1789-1799.

PMID
27412887
Full Text

Bonilla, FA, Khan, DA, Ballas, ZK, Chinen, J, Frank, MM, Hsu, JT, Keller, M, Kobrynski, LJ, Komarow, HD, Mazer, B, Nelson, RP, Orange, JS, Routes, JM, Shearer, WT, Sorensen, RU, Verbsky, JW, Bernstein, DI, Blessing-Moore, J, Lang, D, Nicklas, RA, Oppenheimer, J, Portnoy, JM, Randolph, CR, Schuller, D, Spector, SL, Tilles, S, Wallace, D, Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology, and the American College of Allergy, Asthma & Immunology et al. "Practice parameter for the diagnosis and management of primary immunodeficiency." The Journal of allergy and clinical immunology 136, no. 5 (November 2015): 1186-205.e1-78-.

PMID
26371839
Full Text

Banerji, A, Busse, P, Christiansen, SC, Li, H, Lumry, W, Davis-Lorton, M, Bernstein, JA, Frank, M, Castaldo, A, Long, JF, Zuraw, BL, and Riedl, M. "Current state of hereditary angioedema management: a patient survey." Allergy and asthma proceedings 36, no. 3 (May 2015): 213-217.

PMID
25976438
Full Text

Christiansen, SC, Bygum, A, Banerji, A, Busse, P, Li, H, Lumry, W, Davis-Lorton, M, Bernstein, JA, Frank, MM, Castaldo, A, Long, JF, Riedl, M, and Zuraw, BL. "Before and after, the impact of available on-demand treatment for HAE." Allergy and asthma proceedings 36, no. 2 (March 2015): 145-150.

PMID
25715243
Full Text

Ding, J-D, Kelly, U, Landowski, M, Toomey, CB, Groelle, M, Miller, C, Smith, SG, Klingeborn, M, Singhapricha, T, Jiang, H, Frank, MM, and Bowes Rickman, C. "Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice." The American journal of pathology 185, no. 1 (January 2015): 29-42.

PMID
25447048
Full Text

Wu, EY, and Frank, MM. "Management of Hereditary Angioedema in Childhood." Pediatric Allergy, Immunology, and Pulmonology 27, no. 4 (December 2014): 165-169.

Full Text

Frank, MM. "Unraveling the Complement System and its Mechanism of Action." In Primary Immunodeficiency Disorders: A Historic and Scientific Perspective, 217-228. August 26, 2014.

Full Text

Frank, MM, and Sullivan, KE. "Deficiencies of the Complement System." In Stiehm's Immune Deficiencies, 731-763. August 12, 2014.

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