Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail Ste 601, Hock Plaza, Box_2714 Med Ctr, Durham, NC 27710
Phone (919) 684-0409
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Sutton, LM, Geradts, J, Hamilton, EP, Havlin, KA, Kimmick, GG, Marcom, PK, Spector, NL, Watson, M, Rabin, DU, Bruno, TO, Noe, A, Miller, S, Subramaniam, C, Layton, S, and Grichnik, K. "CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers." Journal of the National Comprehensive Cancer Network : JNCCN 13, no. 8 (August 2015): 1005-1011.

PMID
26285246
Scholars@Duke

Spector, NL, Robertson, FC, Bacus, S, Blackwell, K, Smith, DA, Glenn, K, Cartee, L, Harris, J, Kimbrough, CL, Gittelman, M, Avisar, E, Beitsch, P, and Koch, KM. "Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor." PloS one 10, no. 11 (January 2015): e0142845-.

PMID
26571496
Scholars@Duke

Howe, MK, Bodoor, K, Carlson, DA, Hughes, PF, Alwarawrah, Y, Loiselle, DR, Jaeger, AM, Darr, DB, Jordan, JL, Hunter, LM, Molzberger, ET, Gobillot, TA, Thiele, DJ, Brodsky, JL, Spector, NL, and Haystead, TA. "Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70." Chemistry & biology 21, no. 12 (December 11, 2014): 1648-1659.

PMID
25500222
Scholars@Duke

Gwin, WR, and Spector, NL. "Pertuzumab protects the achilles' heel of trastuzumab--emtansine." Clin Cancer Res 20, no. 2 (January 15, 2014): 278-280.

PMID
24240115
Full Text

Xia, W, Gooden, D, Liu, L, Zhao, S, Soderblom, EJ, Toone, EJ, Beyer, WF, Walder, H, and Spector, NL. "Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis." PloS one 9, no. 2 (January 2014): e88983-.

PMID
24551203
Scholars@Duke

Proia, DA, Zhang, C, Sequeira, M, Jimenez, JP, He, S, Spector, N, Shapiro, GI, Tolaney, S, Nagai, M, Acquaviva, J, Smith, DL, Sang, J, Bates, RC, and El-Hariry, I. "Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer." Clinical cancer research : an official journal of the American Association for Cancer Research 20, no. 2 (January 2014): 413-424.

PMID
24173541
Scholars@Duke

Barrott, JJ, Hughes, PF, Osada, T, Yang, XY, Hartman, ZC, Loiselle, DR, Spector, NL, Neckers, L, Rajaram, N, Hu, F, Ramanujam, N, Vaidyanathan, G, Zalutsky, MR, Lyerly, HK, and Haystead, TA. "Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells." Chem Biol 20, no. 9 (September 19, 2013): 1187-1197.

PMID
24035283
Full Text

Kurokawa, M, Kim, J, Geradts, J, Matsuura, K, Liu, L, Ran, X, Xia, W, Ribar, TJ, Henao, R, Dewhirst, MW, Kim, WJ, Lucas, JE, Wang, S, Spector, NL, and Kornbluth, S. "A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. (Published online)" Sci Signal 6, no. 274 (May 7, 2013): ra32-.

PMID
23652204
Full Text

Hamilton, E, Blackwell, K, Hobeika, AC, Clay, TM, Broadwater, G, Ren, XR, Chen, W, Castro, H, Lehmann, F, Spector, N, Wei, J, Osada, T, Lyerly, HK, and Morse, MA. "Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion." J Transl Med 11 (2013): 82-.

PMID
23536971
Full Text

Xia, W, Petricoin, EF, Zhao, S, Liu, L, Osada, T, Cheng, Q, Wulfkuhle, JD, Gwin, WR, Yang, X, Gallagher, RI, Bacus, S, Lyerly, HK, and Spector, NL. "An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models." Breast Cancer Res 15, no. 5 (2013): R85-.

PMID
24044505
Full Text

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