Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail Ste 601, Hock Plaza, Box_2714 Med Ctr, Durham, NC 27710
Phone (919) 684-0409
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Osada, T, Hartman, ZC, Wei, J, Lei, G, Hobeika, AC, Gwin, WR, Diniz, MA, Spector, N, Clay, TM, Chen, W, Morse, MA, and Lyerly, HK. "Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers." Breast Cancer Research : Bcr 20, no. 1 (August 9, 2018): 90-null.

PMID
30092835
Full Text

Piryani, SO, Kam, AYF, Kliassov, EG, Chen, BJ, Spector, NL, Chute, JP, Hsu, DS, Chao, NJ, and Doan, PL. "Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration." Stem Cells (Dayton, Ohio) 36, no. 2 (February 2018): 252-264.

PMID
29086459
Full Text

Crowe, LB, Hughes, PF, Alcorta, DA, Osada, T, Smith, AP, Totzke, J, Loiselle, DR, Lutz, ID, Gargesha, M, Roy, D, Roques, J, Darr, D, Lyerly, HK, Spector, NL, and Haystead, TAJ. "A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo." Acs Chemical Biology 12, no. 4 (April 2017): 1047-1055.

PMID
28103010
Full Text

Goh, G, Schmid, R, Guiver, K, Arpornwirat, W, Chitapanarux, I, Ganju, V, Im, S-A, Kim, S-B, Dechaphunkul, A, Maneechavakajorn, J, Spector, N, Yau, T, Afrit, M, Ahmed, SB, Johnston, SR, Gibson, N, Uttenreuther-Fischer, M, Herrero, J, and Swanton, C. "Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine." Plos Medicine 13, no. 12 (December 6, 2016): e1002136-null.

PMID
27923043
Full Text

Zhu, J, Davis, CT, Silberman, S, Spector, N, and Zhang, T. "A role for the androgen receptor in the treatment of male breast cancer." Critical Reviews in Oncology/Hematology 98 (February 2016): 358-363. (Review)

PMID
26669267
Full Text

Oldham, M, Yoon, P, Fathi, Z, Beyer, WF, Adamson, J, Liu, L, Alcorta, D, Xia, W, Osada, T, Liu, C, Yang, XY, Dodd, RD, Herndon, JE, Meng, B, Kirsch, DG, Lyerly, HK, Dewhirst, MW, Fecci, P, Walder, H, and Spector, NL. "X-Ray Psoralen Activated Cancer Therapy (X-PACT)." Plos One 11, no. 9 (January 2016): e0162078-null.

PMID
27583569
Full Text

Sutton, LM, Geradts, J, Hamilton, EP, Havlin, KA, Kimmick, GG, Marcom, PK, Spector, NL, Watson, M, Rabin, DU, Bruno, TO, Noe, A, Miller, S, Subramaniam, C, Layton, S, and Grichnik, K. "CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers." J Natl Compr Canc Netw 13, no. 8 (August 2015): 1005-1011.

PMID
26285246
Scholars@Duke

Spector, NL, Robertson, FC, Bacus, S, Blackwell, K, Smith, DA, Glenn, K, Cartee, L, Harris, J, Kimbrough, CL, Gittelman, M, Avisar, E, Beitsch, P, and Koch, KM. "Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor." PloS one 10, no. 11 (January 2015): e0142845-.

PMID
26571496
Full Text

Howe, MK, Bodoor, K, Carlson, DA, Hughes, PF, Alwarawrah, Y, Loiselle, DR, Jaeger, AM, Darr, DB, Jordan, JL, Hunter, LM, Molzberger, ET, Gobillot, TA, Thiele, DJ, Brodsky, JL, Spector, NL, and Haystead, TAJ. "Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70." Chemistry and Biology 21, no. 12 (December 18, 2014): 1648-1659.

Full Text

Howe, MK, Bodoor, K, Carlson, DA, Hughes, PF, Alwarawrah, Y, Loiselle, DR, Jaeger, AM, Darr, DB, Jordan, JL, Hunter, LM, Molzberger, ET, Gobillot, TA, Thiele, DJ, Brodsky, JL, Spector, NL, and Haystead, TAJ. "Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70." Chemistry & biology 21, no. 12 (December 11, 2014): 1648-1659.

PMID
25500222
Full Text

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