Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box 91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Kao, Chester, Megan McNamara, Chris Alley, Neil Spector, Shekeab Jauhari, Rajan T. Gupta, Tian Zhang, and Jason Zhu. “A Complete Response After Pseudo-progression: Pembrolizumab for Metastatic Squamous Cell Carcinoma (SCC) of the Bladder..” Clin Genitourin Cancer, April 1, 2019. https://doi.org/10.1016/j.clgc.2019.03.019.

PMID
31097390
Full Text

Osada, Takuya, Zachary C. Hartman, Junping Wei, Gangjun Lei, Amy C. Hobeika, William R. Gwin, Marcio A. Diniz, et al. “Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers..” Breast Cancer Res 20, no. 1 (August 9, 2018). https://doi.org/10.1186/s13058-018-1023-x.

PMID
30092835
Full Text

Piryani, Sadhna O., Angel Y. F. Kam, Evelyna G. Kliassov, Benny J. Chen, Neil L. Spector, John P. Chute, David S. Hsu, Nelson J. Chao, and Phuong L. Doan. “Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration..” Stem Cells 36, no. 2 (February 2018): 252–64. https://doi.org/10.1002/stem.2731.

PMID
29086459
Full Text

Crowe, Lauren B., Philip F. Hughes, David A. Alcorta, Takuya Osada, Aaron P. Smith, Juliane Totzke, David R. Loiselle, et al. “A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo..” Acs Chem Biol 12, no. 4 (April 21, 2017): 1047–55. https://doi.org/10.1021/acschembio.7b00006.

PMID
28103010
Full Text

Goh, Gerald, Ramona Schmid, Kelly Guiver, Wichit Arpornwirat, Imjai Chitapanarux, Vinod Ganju, Seock-Ah Im, et al. “Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine..” Plos Med 13, no. 12 (December 2016). https://doi.org/10.1371/journal.pmed.1002136.

PMID
27923043
Full Text

Zhu, Jason, Carter T. Davis, Sandra Silberman, Neil Spector, and Tian Zhang. “A role for the androgen receptor in the treatment of male breast cancer..” Crit Rev Oncol Hematol 98 (February 2016): 358–63. https://doi.org/10.1016/j.critrevonc.2015.11.013.

PMID
26669267
Full Text

Sutton, Linda M., Joseph Geradts, Erika P. Hamilton, Kathleen A. Havlin, Gretchen G. Kimmick, P Kelly Marcom, Neil L. Spector, et al. “CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers..” J Natl Compr Canc Netw 13, no. 8 (August 2015): 1005–11.

PMID
26285246
Scholars@Duke

Spector, Neil L., Faith C. Robertson, Sarah Bacus, Kimberly Blackwell, Deborah A. Smith, Kelli Glenn, Leanne Cartee, et al. “Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor..” Plos One 10, no. 11 (2015). https://doi.org/10.1371/journal.pone.0142845.

PMID
26571496
Full Text

Howe, Matthew K., Khaldon Bodoor, David A. Carlson, Philip F. Hughes, Yazan Alwarawrah, David R. Loiselle, Alex M. Jaeger, et al. “Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70..” Chem Biol 21, no. 12 (December 18, 2014): 1648–59. https://doi.org/10.1016/j.chembiol.2014.10.016.

PMID
25500222
Full Text

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