Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box 91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Howe, M. K., K. Bodoor, D. A. Carlson, P. F. Hughes, Y. Alwarawrah, D. R. Loiselle, A. M. Jaeger, et al. “Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.” Chemistry and Biology 21, no. 12 (December 18, 2014): 1648–59. https://doi.org/10.1016/j.chembiol.2014.10.016.

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Proia, David A., Chaohua Zhang, Manuel Sequeira, John-Paul Jimenez, Suqin He, Neil Spector, Geoffrey I. Shapiro, et al. “Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer..” Clin Cancer Res 20, no. 2 (January 15, 2014): 413–24. https://doi.org/10.1158/1078-0432.CCR-13-2166.

PMID
24173541
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Xia, Wenle, David Gooden, Leihua Liu, Sumin Zhao, Erik J. Soderblom, Eric J. Toone, Wayne F. Beyer, Harold Walder, and Neil L. Spector. “Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis..” Plos One 9, no. 2 (2014). https://doi.org/10.1371/journal.pone.0088983.

PMID
24551203
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Barrott, Jared J., Philip F. Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C. Hartman, David R. Loiselle, Neil L. Spector, et al. “Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells..” Chem Biol 20, no. 9 (September 19, 2013): 1187–97. https://doi.org/10.1016/j.chembiol.2013.08.004.

PMID
24035283
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Kurokawa, Manabu, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Xu Ran, Wenle Xia, et al. “A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53..” Sci Signal 6, no. 274 (May 7, 2013). https://doi.org/10.1126/scisignal.2003741.

PMID
23652204
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Hamilton, E., K. Blackwell, A. C. Hobeika, T. M. Clay, G. Broadwater, X. R. Ren, W. Chen, et al. “Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion..” J Transl Med, 2013. https://doi.org/10.1186/1479-5876-11-82.

PMID
23536971
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Xia, Wenle, Emanual F. Petricoin, Sumin Zhao, Leihua Liu, Takuya Osada, Qing Cheng, Julia D. Wulfkuhle, et al. “An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models..” Breast Cancer Res 15, no. 5 (2013). https://doi.org/10.1186/bcr3480.

PMID
24044505
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Ren, Xiu-Rong, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Wenle Xia, Neil Spector, et al. “Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells..” Breast Cancer Res 14, no. 3 (June 7, 2012). https://doi.org/10.1186/bcr3204.

PMID
22676470
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Cheng, Qing, Jeffrey T. Chang, Joseph Geradts, Leonard M. Neckers, Timothy Haystead, Neil L. Spector, and H Kim Lyerly. “Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer..” Breast Cancer Res 14, no. 2 (April 17, 2012). https://doi.org/10.1186/bcr3168.

PMID
22510516
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