Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail Ste 601, Hock Plaza, Box_2714 Med Ctr, Durham, NC 27710
Phone (919) 684-0409
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Gwin, WR, and Spector, NL. "Pertuzumab protects the achilles' heel of trastuzumab--emtansine." Clin Cancer Res 20, no. 2 (January 15, 2014): 278-280.

PMID
24240115
Full Text

Xia, W, Gooden, D, Liu, L, Zhao, S, Soderblom, EJ, Toone, EJ, Beyer, WF, Walder, H, and Spector, NL. "Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis." PloS one 9, no. 2 (January 2014): e88983-.

PMID
24551203
Full Text

Proia, DA, Zhang, C, Sequeira, M, Jimenez, J-P, He, S, Spector, N, Shapiro, GI, Tolaney, S, Nagai, M, Acquaviva, J, Smith, DL, Sang, J, Bates, RC, and El-Hariry, I. "Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 20, no. 2 (January 2014): 413-424.

PMID
24173541
Full Text

Barrott, JJ, Hughes, PF, Osada, T, Yang, X-Y, Hartman, ZC, Loiselle, DR, Spector, NL, Neckers, L, Rajaram, N, Hu, F, Ramanujam, N, Vaidyanathan, G, Zalutsky, MR, Lyerly, HK, and Haystead, TA. "Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells." Chem Biol 20, no. 9 (September 19, 2013): 1187-1197.

PMID
24035283
Full Text

Kurokawa, M, Kim, J, Geradts, J, Matsuura, K, Liu, L, Ran, X, Xia, W, Ribar, TJ, Henao, R, Dewhirst, MW, Kim, W-J, Lucas, JE, Wang, S, Spector, NL, and Kornbluth, S. "A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53." Science Signaling 6, no. 274 (May 7, 2013): ra32-null.

PMID
23652204
Full Text

Hamilton, E, Blackwell, K, Hobeika, AC, Clay, TM, Broadwater, G, Ren, X-R, Chen, W, Castro, H, Lehmann, F, Spector, N, Wei, J, Osada, T, Lyerly, HK, and Morse, MA. "Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion." Journal of Translational Medicine 11 (January 2013): 82-82.

PMID
23536971
Full Text

Xia, W, Petricoin, EF, Zhao, S, Liu, L, Osada, T, Cheng, Q, Wulfkuhle, JD, Gwin, WR, Yang, X, Gallagher, RI, Bacus, S, Lyerly, HK, and Spector, NL. "An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models." Breast Cancer Res 15, no. 5 (2013): R85-null.

PMID
24044505
Full Text

Ren, X-R, Wei, J, Lei, G, Wang, J, Lu, J, Xia, W, Spector, N, Barak, LS, Clay, TM, Osada, T, Hamilton, E, Blackwell, K, Hobeika, AC, Morse, MA, Lyerly, HK, and Chen, W. "Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. (Published online)" Breast Cancer Res 14, no. 3 (June 7, 2012): R89-.

PMID
22676470
Full Text

Cheng, Q, Chang, JT, Geradts, J, Neckers, LM, Haystead, T, Spector, NL, and Lyerly, HK. "Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. (Published online)" Breast Cancer Res 14, no. 2 (April 17, 2012): R62-.

PMID
22510516
Full Text

Hamilton, E, Blackwell, K, Hobeika, AC, Clay, TM, Broadwater, G, Ren, X-R, Chen, W, Castro, H, Lehmann, F, Spector, N, Wei, J, Osada, T, Lyerly, HK, and Morse, MA. "Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected]. (Published online)" J Transl Med 10 (February 10, 2012): 28-.

PMID
22325452
Full Text

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