Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box_91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Il'yasova, D, Siamakpour-Reihani, S, Akushevich, I, Akushevich, L, Spector, N, and Schildkraut, J. "What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?." Breast Cancer Res Treat 130, no. 2 (November 2011): 691-697.

PMID
21850396
Full Text

Xia, W, Liu, Z, Zong, R, Liu, L, Zhao, S, Bacus, SS, Mao, Y, He, J, Wulfkuhle, JD, Petricoin, EF, Osada, T, Yang, X-Y, Hartman, ZC, Clay, TM, Blackwell, KL, Lyerly, HK, and Spector, NL. "Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors." Molecular Cancer Therapeutics 10, no. 8 (August 2011): 1367-1374.

PMID
21673090
Full Text

Spector, NL, and Blackwell, KL. "Reply to F. Bellati et al." Journal of Clinical Oncology 28, no. 21 (July 20, 2010). (Letter)

Full Text

Boussen, H, Cristofanilli, M, Zaks, T, DeSilvio, M, Salazar, V, and Spector, N. "Phase II study to evaluate the efficacy and safety of neoadjuvant lapatinib plus paclitaxel in patients with inflammatory breast cancer." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 28, no. 20 (July 2010): 3248-3255.

PMID
20530274
Full Text

Morse, MA, Wei, J, Hartman, Z, Xia, W, Ren, X-R, Lei, G, Barry, WT, Osada, T, Hobeika, AC, Peplinski, S, Jiang, H, Devi, GR, Chen, W, Spector, N, Amalfitano, A, Lyerly, HK, and Clay, TM. "Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo." International Journal of Cancer 126, no. 12 (June 2010): 2893-2903.

PMID
19856307
Full Text

Hartman, ZC, Wei, J, Osada, T, Glass, O, Lei, G, Yang, X-Y, Peplinski, S, Kim, D-W, Xia, W, Spector, N, Marks, J, Barry, W, Hobeika, A, Devi, G, Amalfitano, A, Morse, MA, Lyerly, HK, and Clay, TM. "An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 16, no. 5 (March 2010): 1466-1477.

PMID
20179231
Full Text

Xia, W, Bacus, S, Husain, I, Liu, L, Zhao, S, Liu, Z, Moseley, MA, Thompson, JW, Chen, FL, Koch, KM, and Spector, NL. "Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA." Molecular Cancer Therapeutics 9, no. 2 (February 2, 2010): 292-299.

PMID
20124457
Full Text

Spector, NL, and Blackwell, KL. "Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer." J Clin Oncol 27, no. 34 (December 1, 2009): 5838-5847. (Review)

PMID
19884552
Full Text

Burris, HA, Taylor, CW, Jones, SF, Koch, KM, Versola, MJ, Arya, N, Fleming, RA, Smith, DA, Pandite, L, Spector, N, and Wilding, G. "A phase I and pharmacokinetic study of oral lapatinib administered once or twice daily in patients with solid malignancies." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 21 (November 2009): 6702-6708.

PMID
19825948
Full Text

Kaufman, B, Trudeau, M, Awada, A, Blackwell, K, Bachelot, T, Salazar, V, DeSilvio, M, Westlund, R, Zaks, T, Spector, N, and Johnston, S. "Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study." The Lancet. Oncology 10, no. 6 (June 2009): 581-588.

PMID
19394894
Full Text

Pages