Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box_91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Chen, FL, Xia, W, and Spector, NL. "Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 14, no. 21 (November 2008): 6730-6734. (Review)

PMID
18980964
Full Text

Osada, T, Chong, G, Tansik, R, Hong, T, Spector, N, Kumar, R, Hurwitz, HI, Dev, I, Nixon, AB, Lyerly, HK, Clay, T, and Morse, MA. "The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients." Cancer Immunology, Immunotherapy : Cii 57, no. 8 (August 2008): 1115-1124.

PMID
18193223
Full Text

Johnston, S, Trudeau, M, Kaufman, B, Boussen, H, Blackwell, K, LoRusso, P, Lombardi, DP, Ben Ahmed, S, Citrin, DL, DeSilvio, ML, Harris, J, Westlund, RE, Salazar, V, Zaks, TZ, and Spector, NL. "Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 26, no. 7 (March 2008): 1066-1072.

PMID
18212337
Full Text

Spector, N, Pegram, M, Perez, EA, and Piccart, M. "Expert roundtable: Emerging questions in ErbB2-positive breast cancer; February 22, 2007." Clinical Breast Cancer 8, no. SUPPL. 3 (January 1, 2008).

Full Text

Spector, N. "Treatment of metastatic ErbB2-positive breast cancer: Options after progression on trastuzumab." Clinical Breast Cancer 8, no. SUPPL. 3 (January 1, 2008).

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Katz, M, Amit, I, Citri, A, Shay, T, Carvalho, S, Lavi, S, Milanezi, F, Lyass, L, Amariglio, N, Jacob-Hirsch, J, Ben-Chetrit, N, Tarcic, G, Lindzen, M, Avraham, R, Liao, Y-C, Trusk, P, Lyass, A, Rechavi, G, Spector, NL, Lo, SH, Schmitt, F, Bacus, SS, and Yarden, Y. "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration." Nature Cell Biology 9, no. 8 (August 2007): 961-969.

PMID
17643115
Full Text

Spector, NL, Yarden, Y, Smith, B, Lyass, L, Trusk, P, Pry, K, Hill, JE, Xia, W, Seger, R, and Bacus, SS. "Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells." Proceedings of the National Academy of Sciences of the United States of America 104, no. 25 (June 7, 2007): 10607-10612.

PMID
17556544
Full Text

Spector, N, Xia, W, El-Hariry, I, Yarden, Y, and Bacus, S. "HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors." Breast Cancer Research 9, no. 2 (March 2, 2007). (Review)

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Xia, W, Husain, I, Liu, L, Bacus, S, Saini, S, Spohn, J, Pry, K, Westlund, R, Stein, SH, and Spector, NL. "Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers." Cancer Research 67, no. 3 (February 2007): 1170-1175.

PMID
17283152
Full Text

Xia, W, Bacus, S, Hegde, P, Husain, I, Strum, J, Liu, L, Paulazzo, G, Lyass, L, Trusk, P, Hill, J, Harris, J, and Spector, NL. "A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer." Proceedings of the National Academy of Sciences of the United States of America 103, no. 20 (May 8, 2006): 7795-7800.

PMID
16682622
Full Text

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