Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box 91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Kaufman, Bella, Maureen Trudeau, Ahmad Awada, Kimberly Blackwell, Thomas Bachelot, Vanessa Salazar, Michelle DeSilvio, et al. “Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+ cohort in EGF103009, a phase II study..” Lancet Oncol 10, no. 6 (June 2009): 581–88. https://doi.org/10.1016/S1470-2045(09)70087-7.

PMID
19394894
Full Text

Osada, Takuya, Gabriel Chong, Robert Tansik, Timothy Hong, Neil Spector, Rakesh Kumar, Herbert I. Hurwitz, et al. “The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients..” Cancer Immunol Immunother 57, no. 8 (August 2008): 1115–24. https://doi.org/10.1007/s00262-007-0441-x.

PMID
18193223
Full Text

Johnston, Stephen, Maureen Trudeau, Bella Kaufman, Hamouda Boussen, Kimberley Blackwell, Patricia LoRusso, Donald P. Lombardi, et al. “Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy..” J Clin Oncol 26, no. 7 (March 1, 2008): 1066–72. https://doi.org/10.1200/JCO.2007.13.9949.

PMID
18212337
Full Text

Spector, N., M. Pegram, E. A. Perez, and M. Piccart. “Expert roundtable: Emerging questions in ErbB2-positive breast cancer; February 22, 2007.” Clinical Breast Cancer 8, no. SUPPL. 3 (January 1, 2008). https://doi.org/10.3816/CBC.2008.s.009.

Full Text

Katz, Menachem, Ido Amit, Ami Citri, Tal Shay, Silvia Carvalho, Sara Lavi, Fernanda Milanezi, et al. “A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration..” Nat Cell Biol 9, no. 8 (August 2007): 961–69. https://doi.org/10.1038/ncb1622.

PMID
17643115
Full Text

Spector, Neil L., Yosef Yarden, Bradley Smith, Ljuba Lyass, Patricia Trusk, Karen Pry, Jason E. Hill, Wenle Xia, Rony Seger, and Sarah S. Bacus. “Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells..” Proceedings of the National Academy of Sciences of the United States of America 104, no. 25 (June 7, 2007): 10607–12. https://doi.org/10.1073/pnas.0701286104.

PMID
17556544
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Spector, N., W. Xia, I. El-Hariry, Y. Yarden, and S. Bacus. “HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors.” Breast Cancer Research 9, no. 2 (March 2, 2007). https://doi.org/10.1186/bcr1652.

Full Text

Xia, Wenle, Intisar Husain, Leihua Liu, Sarah Bacus, Shermini Saini, Janice Spohn, Karen Pry, Ron Westlund, Steven H. Stein, and Neil L. Spector. “Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers..” Cancer Res 67, no. 3 (February 1, 2007): 1170–75. https://doi.org/10.1158/0008-5472.CAN-06-2101.

PMID
17283152
Full Text

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