Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box 91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Xia, Wenle, Sarah Bacus, Priti Hegde, Intisar Husain, Jay Strum, Leihua Liu, Georgina Paulazzo, et al. “A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer..” Proc Natl Acad Sci U S A 103, no. 20 (May 16, 2006): 7795–7800. https://doi.org/10.1073/pnas.0602468103.

PMID
16682622
Full Text

Xia, Wenle, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick, Katherine M. Graham, Amanda L. Treece, et al. “Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers..” Cancer Res 66, no. 3 (February 1, 2006): 1640–47. https://doi.org/10.1158/0008-5472.CAN-05-2000.

PMID
16452223
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Kelly, H., M. Graham, E. Humes, L. J. Dorflinger, K. A. Boggess, B. H. O’Neil, J. Harris, N. L. Spector, and E. C. Dees. “Delivery of a healthy baby after first-trimester maternal exposure to lapatinib.” Clinical Breast Cancer 7, no. 4 (January 1, 2006): 339–41. https://doi.org/10.3816/CBC.2006.n.048.

Full Text

Xia, Wenle, Catherine M. Gerard, Leihua Liu, Nathalie M. Baudson, Thierry L. Ory, and Neil L. Spector. “Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells..” Oncogene 24, no. 41 (September 15, 2005): 6213–21. https://doi.org/10.1038/sj.onc.1208774.

PMID
16091755
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Burris, Howard A., Herbert I. Hurwitz, E Claire Dees, Afshin Dowlati, Kimberly L. Blackwell, Bert O’Neil, Paul K. Marcom, et al. “Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas..” J Clin Oncol 23, no. 23 (August 10, 2005): 5305–13. https://doi.org/10.1200/JCO.2005.16.584.

PMID
15955900
Full Text

Spector, Neil L., Wenle Xia, Howard Burris, Herbert Hurwitz, E Claire Dees, Afshin Dowlati, Bert O’Neil, et al. “Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies..” J Clin Oncol 23, no. 11 (April 10, 2005): 2502–12. https://doi.org/10.1200/JCO.2005.12.157.

PMID
15684311
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Bence, Aimee K., Eric B. Anderson, Maqbool A. Halepota, Michael A. Doukas, Phillip A. DeSimone, George A. Davis, Deborah A. Smith, et al. “Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects..” Invest New Drugs 23, no. 1 (January 2005): 39–49. https://doi.org/10.1023/B:DRUG.0000047104.45929.ea.

PMID
15528979
Full Text

Czito, Brian G., Timothy J. Hong, Darrel P. Cohen, Douglas S. Tyler, Catherine G. Lee, Mitchell S. Anscher, Kirk A. Ludwig, et al. “A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon..” Int J Radiat Oncol Biol Phys 58, no. 3 (March 1, 2004): 779–85. https://doi.org/10.1016/S0360-3016(03)01567-0.

PMID
14967434
Full Text

Xia, Wenle, Lei-Hua Liu, Peter Ho, and Neil L. Spector. “Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016..” Oncogene 23, no. 3 (January 22, 2004): 646–53. https://doi.org/10.1038/sj.onc.1207166.

PMID
14737100
Full Text

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