Neil Lee Spector, MD

Associate Professor of Medicine
Sandra Coates Associate Professor
Associate Professor of Pharmacology & Cancer Biology
Member of the Duke Cancer Institute
Campus mail 450 Research Drive, B354, Box 91004 Med Ctr, Durham, NC 27708
Phone (919) 668-1094
Email address neil.spector@duke.edu

Education and Training

  • Medical Resident, Medicine, University of Texas at Dallas, 1984 - 1986
  • First Year Neurology Resident, Neurology, University of Texas at Dallas, 1983 - 1984
  • Intern, Medicine, University of Texas at Dallas, 1982 - 1983
  • M.D., University of Medicine and Dentistry of New Jersey, 1982

Publications

Xia, Wenle, Lys Hardy, Leihua Liu, Sumin Zhao, Mark Goodman, Richard Voellmy, and Neil L. Spector. “Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells..” Breast Cancer Res Treat 77, no. 3 (February 2003): 233–43.

PMID
12602923
Scholars@Duke

Xia, Wenle, Robert J. Mullin, Barry R. Keith, Lei-Hua Liu, Hong Ma, David W. Rusnak, Gary Owens, Krystal J. Alligood, and Neil L. Spector. “Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways..” Oncogene 21, no. 41 (September 12, 2002): 6255–63. https://doi.org/10.1038/sj.onc.1205794.

PMID
12214266
Full Text

Smith, B. L., D. Altomare, N. L. Spector, and S. S. Bacus. “8 Role of immunohistochemical expression of AKT protein in breast carcinoma” 1 (January 1, 2002): 307–19. https://doi.org/10.1016/S1874-5784(04)80042-4.

Full Text

Xia, W., S. Spector, L. Hardy, S. Zhao, A. Saluk, L. Alemane, and N. L. Spector. “Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine..” Proc Natl Acad Sci U S A 97, no. 13 (June 20, 2000): 7494–99. https://doi.org/10.1073/pnas.97.13.7494.

PMID
10861014
Full Text

Xia, W., R. Voellmy, and N. L. Spector. “Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1..” J Cell Physiol 183, no. 3 (June 2000): 425–31. https://doi.org/10.1002/(SICI)1097-4652(200006)183:3<425::AID-JCP16>3.0.CO;2-M.

PMID
10797318
Full Text

Xia, W., R. Voellmy, and N. L. Spector. “Sensitization of tumor cells to Fas killing through overexpression of heat-shock transcription factor 1.” Journal of Cellular Physiology 183, no. 3 (May 17, 2000): 425–31. https://doi.org/10.1002/(SICI)1097-4652(200006)183:3<425::AID-JCP16>3.0.CO;2-M.

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Goodman, M., N. Spector, G. Rodrigues, and P. A. Cassileth. “Interleukin-2 therapy for advanced chronic myeloid leukemia..” Leukemia 12, no. 11 (November 1998): 1682–84.

PMID
9823941
Scholars@Duke

Rao, J., F. Zhang, R. J. Donnelly, N. L. Spector, and G. P. Studzinski. “Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells..” J Cell Physiol 175, no. 2 (May 1998): 121–28. https://doi.org/10.1002/(SICI)1097-4652(199805)175:2<121::AID-JCP1>3.0.CO;2-Q.

PMID
9525470
Full Text

Koya, R., J. Andersen, H. Fernandez, M. Goodman, N. Spector, R. Smith, J. Hanlon, and P. A. Cassileth. “Analysis of the value of empiric vancomycin administration in febrile neutropenia occurring after autologous peripheral blood stem cell transplants..” Bone Marrow Transplant 21, no. 9 (May 1998): 923–26. https://doi.org/10.1038/sj.bmt.1701201.

PMID
9613785
Full Text

Rao, J., F. Zhang, R. J. Donnelly, N. L. Spector, and G. P. Studzinski. “Truncation of sp1 transcription factor by myeloblastin in undifferentiated HL60 cells.” Journal of Cellular Physiology 175, no. 2 (1998): 121–28. https://doi.org/10.1002/(SICI)1097-4652(199805)175:2<121::AID-JCP1>3.0.CO;2-Q.

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