Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972


Stokes, D. L., N. R. MacIntyre, and J. A. Nadel. “Nonlinear increases in diffusing capacity during exercise by seated and supine subjects.” J Appl Physiol Respir Environ Exerc Physiol 51, no. 4 (October 1981): 858–63.

Full Text

MacIntyre, N. R., J. R. Kunkler, R. E. Mitchell, A. Oberman, and A. Graybiel. “Eight-year follow-up of exercise electrocardiograms in healthy, middle-aged aviators.” Aviat Space Environ Med 52, no. 4 (April 1981): 256–59.


MacIntyre, N. R., R. E. Mitchell, A. Oberman, W. R. Harlan, and A. Graybiel. “Long-term follow-up of lung volume measurements in initially healthy young aviators.” Aviat Space Environ Med 52, no. 1 (January 1981): 1–5.


MacIntyre, N. R., R. E. Mitchell, A. Oberman, W. R. Harlan, A. Graybiel, and E. Johnson. “Longevity in military pilots: 37-year followup of the Navy's "1000 aviators".” Aviat Space Environ Med 49, no. 9 (September 1978): 1120–22.