Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Long-Term Oxygen Treatment Trial Research Group, Christopher, Richard K. Albert, David H. Au, Amanda L. Blackford, Richard Casaburi, J Allen Cooper, Gerard J. Criner, et al. “A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation.” The New England Journal of Medicine 375, no. 17 (October 2016): 1617–27. https://doi.org/10.1056/nejmoa1604344.

PMID
27783918
Full Text

Sun, Wei, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A. Hawkins, Jenny Yang, Ting-Huei Chen, et al. “Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.” Plos Genetics 12, no. 8 (August 17, 2016): e1006011. https://doi.org/10.1371/journal.pgen.1006011.

PMID
27532455
Full Text

Nguyen, Albert P., Ulrich H. Schmidt, and Neil R. MacIntyre. “Should High-Frequency Ventilation in the Adult Be Abandoned?” Respir Care 61, no. 6 (June 2016): 791–800. https://doi.org/10.4187/respcare.04584.

PMID
27235314
Full Text

Schmidt, Ulrich H., Lauren Knecht, and Neil R. MacIntyre. “Should Early Mobilization Be Routine in Mechanically Ventilated Patients?” Respir Care 61, no. 6 (June 2016): 867–75. https://doi.org/10.4187/respcare.04566.

PMID
27235319
Full Text

Vaz Fragoso, Carlos A., Gail McAvay, Peter H. Van Ness, Richard Casaburi, Robert L. Jensen, Neil MacIntyre, H Klar Yaggi, Thomas M. Gill, and John Concato. “Phenotype of Spirometric Impairment in an Aging Population.” American Journal of Respiratory and Critical Care Medicine 193, no. 7 (April 2016): 727–35. https://doi.org/10.1164/rccm.201508-1603oc.

PMID
26540012
Full Text

Busch, Robert, MeiLan K. Han, Russell P. Bowler, Mark T. Dransfield, J Michael Wells, Elizabeth A. Regan, Craig P. Hersh, and Craig P. COPDGene Investigators. “Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort.” Bmc Pulm Med 16 (February 10, 2016): 28. https://doi.org/10.1186/s12890-016-0191-7.

PMID
26861867
Full Text

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