Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Fink, JB, and Macintyre, NR. "Discussion." Respiratory Care 60, no. 6 (June 1, 2015): 790-793.

Scholars@Duke

Macintyre, NR, and Fink, JB. "Discussion." Respiratory Care 60, no. 6 (June 1, 2015): 891-893.

Scholars@Duke

Grissom, Colin K., Eliotte L. Hirshberg, Justin B. Dickerson, Samuel M. Brown, Michael J. Lanspa, Kathleen D. Liu, David Schoenfeld, et al. “Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*..” Critical Care Medicine 43, no. 2 (February 2015): 288–95. https://doi.org/10.1097/CCM.0000000000000715.

PMID
25599463
Full Text

Macintyre, NR, and Fink, JB. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 847-849.

Scholars@Duke

Schell-Chaple, Hildy M., Kathleen A. Puntillo, Michael A. Matthay, Kathleen D. Liu, and Kathleen D. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. “Body temperature and mortality in patients with acute respiratory distress syndrome..” American Journal of Critical Care : An Official Publication, American Association of Critical Care Nurses 24, no. 1 (January 2015): 15–23. https://doi.org/10.4037/ajcc2015320.

PMID
25554550
Full Text

Fink, JB, Macintyre, NR, and Suggett, JA. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 821-824.

Scholars@Duke

Fink, JB, and Macintyre, NR. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 874-879.

Scholars@Duke

Suggett, JA, Fink, JB, and Macintyre, NR. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 830-832.

Scholars@Duke

Macintyre, NR, and Fink, JB. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 955-957.

Scholars@Duke

Macintyre, NR. "Discussion." Respiratory Care 60, no. 6 (January 1, 2015): 802-805.

Scholars@Duke

Pages