Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Hobbs, Brian D., Marilyn G. Foreman, Russell Bowler, Francine Jacobson, Barry J. Make, Peter J. Castaldi, Raúl San José Estépar, Edwin K. Silverman, Craig P. Hersh, and Craig P. COPDGene Investigators. “Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.” Ann Am Thorac Soc 11, no. 9 (November 2014): 1387–94. https://doi.org/10.1513/AnnalsATS.201405-224OC.

PMID
25295410
Full Text

Hersh, Craig P., Barry J. Make, David A. Lynch, R Graham Barr, Russell P. Bowler, Peter M. A. Calverley, Peter J. Castaldi, et al. “Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.” Bmc Pulm Med 14 (October 24, 2014): 164. https://doi.org/10.1186/1471-2466-14-164.

PMID
25341556
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Bowler, Russell P., Victor Kim, Elizabeth Regan, André A. A. Williams, Stephanie A. Santorico, Barry J. Make, David A. Lynch, et al. “Prediction of acute respiratory disease in current and former smokers with and without COPD.” Chest 146, no. 4 (October 2014): 941–50. https://doi.org/10.1378/chest.13-2946.

PMID
24945159
Full Text

Sottile, Peter D., Marc Moss, Jayshil J. Patel, Jonathon D. Truwit, Maryam Sheikh, Janice L. Zimmerman, Amit Diwakar, et al. “ATS Core Curriculum 2014: Part II. Adult critical care medicine.” Ann Am Thorac Soc 11, no. 8 (October 2014): 1307–15. https://doi.org/10.1513/AnnalsATS.201407-322CME.

PMID
25343197
Full Text

Lee, Jin Hwa, Michael H. Cho, Craig P. Hersh, Merry-Lynn N. McDonald, James D. Crapo, Per S. Bakke, Amund Gulsvik, et al. “Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.” Respir Res 15 (September 21, 2014): 113. https://doi.org/10.1186/s12931-014-0113-2.

PMID
25241909
Full Text

Lee, Jin Hwa, Merry-Lynn N. McDonald, Michael H. Cho, Emily S. Wan, Peter J. Castaldi, Gary M. Hunninghake, Nathaniel Marchetti, et al. “DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.” Respir Res 15 (August 20, 2014): 97. https://doi.org/10.1186/s12931-014-0097-y.

PMID
25134640
Full Text

Wan, Emily S., Peter J. Castaldi, Michael H. Cho, John E. Hokanson, Elizabeth A. Regan, Barry J. Make, Terri H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.” Respir Res 15 (August 6, 2014): 89. https://doi.org/10.1186/s12931-014-0089-y.

PMID
25096860
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Wan, E. S., P. J. Castaldi, M. H. Cho, J. E. Hokanson, E. A. Regan, B. J. Make, T. H. Beaty, et al. “Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.” Respiratory Research 15, no. 1 (August 6, 2014). https://doi.org/10.1186/s12931-014-0089-y.

Full Text

Pathak, Vikas, Ian Welsby, Kamran Mahmood, Momen Wahidi, Neil MacIntyre, and Scott Shofer. “Ventilation and anesthetic approaches for rigid bronchoscopy.” Ann Am Thorac Soc 11, no. 4 (May 2014): 628–34. https://doi.org/10.1513/AnnalsATS.201309-302FR.

PMID
24635585
Full Text

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