Neil Ross MacIntyre, MD

Professor of Medicine
Campus mail 1120 Hosp North, Durham, NC 27710
Phone (919) 681-2720
Email address macin001@mc.duke.edu

1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.

2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.

3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.

4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.

Education and Training

  • M.D., Cornell University, 1972

Publications

Cho, Michael H., Merry-Lynn N. McDonald, Xiaobo Zhou, Manuel Mattheisen, Peter J. Castaldi, Craig P. Hersh, Dawn L. Demeo, et al. “Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis..” Lancet Respir Med 2, no. 3 (March 2014): 214–25. https://doi.org/10.1016/S2213-2600(14)70002-5.

PMID
24621683
Full Text

Swigris, Jeffrey J., David L. Streiner, Kevin K. Brown, Amanda Belkin, Kathy E. Green, Frederick S. Wamboldt, and Frederick S. IPFnet Investigators. “Assessing exertional dyspnea in patients with idiopathic pulmonary fibrosis..” Respir Med 108, no. 1 (January 2014): 181–88. https://doi.org/10.1016/j.rmed.2013.12.009.

PMID
24388667
Full Text

Matthay, M. A., R. G. Brower, S. Carson, I. S. Douglas, M. Eisner, D. Hite, S. Holets, R. H. Kallet, K. D. Liu, and N. MacIntyre. “Erratum: Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury (American Journal of Respiratory and Critical Care Medicine (2011) 184 (561-568)).” American Journal of Respiratory and Critical Care Medicine 188, no. 11 (December 1, 2013).

Scholars@Duke

Halaweish, Ahmed F., Richard E. Moon, W Michael Foster, Brian J. Soher, H Page McAdams, James R. MacFall, Maureen D. Ainslie, Neil R. MacIntyre, and H Cecil Charles. “Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans..” Chest 144, no. 4 (October 2013): 1300–1310. https://doi.org/10.1378/chest.12-2597.

PMID
23722696
Full Text

Collard, Harold R., Eric Yow, Luca Richeldi, Kevin J. Anstrom, Craig Glazer, and Craig IPFnet investigators. “Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials..” Respir Res 14 (July 13, 2013). https://doi.org/10.1186/1465-9921-14-73.

PMID
23848435
Full Text

MacIntyre, Neil. “Patient-ventilator trigger dys-synchrony: a common phenomenon with important implications..” Crit Care 17, no. 3 (June 18, 2013). https://doi.org/10.1186/cc12729.

PMID
23806185
Full Text

Scott, J Brady, Michael A. Gentile, Stacey N. Bennett, MaryAnn Couture, and Neil R. MacIntyre. “Apnea testing during brain death assessment: a review of clinical practice and published literature..” Respir Care 58, no. 3 (March 2013): 532–38. https://doi.org/10.4187/respcare.01962.

PMID
22709413
Full Text

Pages