Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Distinguished Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Chief, Division of Cell Therapy in the Department of Medicine
Member of the Duke Cancer Institute
Affiliate of the Duke Regeneration Center
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.

PMID
33122357
Full Text

Cairo, Mitchell S., Kenneth R. Cooke, Hillard M. Lazarus, and Nelson Chao. “Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation.” Br J Haematol 190, no. 6 (September 2020): 822–36. https://doi.org/10.1111/bjh.16557.

PMID
32133623
Full Text

Sung, Anthony D., Richard C. Yen, Yiqun Jiao, Alyssa Bernanke, Deborah A. Lewis, Sara E. Miller, Zhiguo Li, et al. “Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenia-Related Bleeding.” Radiat Res 194, no. 2 (August 1, 2020): 162–72. https://doi.org/10.1667/RADE-20-00016.

PMID
32845987
Full Text

Hildebrandt, Gerhard C., and Nelson Chao. “Endothelial cell function and endothelial-related disorders following haematopoietic cell transplantation.” Br J Haematol 190, no. 4 (August 2020): 508–19. https://doi.org/10.1111/bjh.16621.

PMID
32319084
Full Text

Olson, Adam C., Franco Afyusisye, Joe Egger, David Noyd, Beda Likonda, Nestory Masalu, Gita Suneja, Nelson Chao, Leah L. Zullig, and Kristin Schroeder. “Cancer incidence and treatment utilization patterns at a regional cancer center in Tanzania from 2008-2016: Initial report of 2,772 cases.” Cancer Epidemiol 67 (August 2020): 101772. https://doi.org/10.1016/j.canep.2020.101772.

PMID
32653779
Full Text

Sung, Anthony D., Krista R. Nichols, and Nelson J. Chao. “House calls for stem cell transplant patients during the COVID-19 pandemic.” Blood 136, no. 3 (July 16, 2020): 370–71. https://doi.org/10.1182/blood.2020006573.

PMID
32488235
Full Text

Markey, Kate A., Jonas Schluter, Antonio L. C. Gomes, Eric R. Littmann, Amanda J. Pickard, Bradford P. Taylor, Paul A. Giardina, et al. “The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD.” Blood 136, no. 1 (July 2, 2020): 130–36. https://doi.org/10.1182/blood.2019003369.

PMID
32430495
Full Text

Cardones, Adela, Nicole Leung, Keith Sullivan, Nelson Chao, Cynthia Green, Lionel Bañez, Mark L. Palmeri, et al. “Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography,” July 2, 2020. https://doi.org/10.7924/r4h995b4q.

Full Text

Sung, Anthony D., Shekeab Jauhari, Sharareh Siamakpour-Reihani, Arati V. Rao, Janet Staats, Cliburn Chan, Everett Meyer, et al. “Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.” Am J Hematol 95, no. 6 (June 2020): 662–71. https://doi.org/10.1002/ajh.25781.

PMID
32162718
Full Text

Pages