Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Research Professor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Maria E. Gooding, Congxiao Liu, Barton F. Haynes, and Nelson J. Chao. “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution..” Blood 99, no. 1 (January 1, 2002): 364–71. https://doi.org/10.1182/blood.v99.1.364.

PMID
11756193
Full Text

Chao, Nelson J., Cong X. Liu, Barbara Rooney, Benny J. Chen, Gwynn D. Long, James J. Vredenburgh, Ashley Morris, Cristina Gasparetto, and David A. Rizzieri. “Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells..” Biol Blood Marrow Transplant 8, no. 5 (2002): 249–56. https://doi.org/10.1053/bbmt.2002.v8.pm12064361.

PMID
12064361
Full Text

Stuart, Monic J., William P. Peters, Gloria Broadwater, Atif Hussein, Maureen Ross, Lawrence B. Marks, Rodney J. Folz, et al. “High-dose chemotherapy and hematopoietic support for patients with high-risk primary breast cancer and involvement of 4 to 9 lymph nodes..” Biol Blood Marrow Transplant 8, no. 12 (2002): 666–73. https://doi.org/10.1053/bbmt.2002.v8.abbmt080666.

PMID
12523579
Full Text

Rizzieri, D. A., G. D. Long, J. J. Vredenburgh, C. Gasparetto, A. Morris, T. T. Stenzel, P. Davis, and N. J. Chao. “Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen..” Blood 98, no. 12 (December 1, 2001): 3486–88. https://doi.org/10.1182/blood.v98.12.3486.

PMID
11719394
Full Text

Goker, H., I. C. Haznedaroglu, and N. J. Chao. “Acute graft-vs-host disease: pathobiology and management..” Exp Hematol 29, no. 3 (March 2001): 259–77. https://doi.org/10.1016/s0301-472x(00)00677-9.

PMID
11274753
Full Text

Horning, S. J., R. S. Negrin, R. T. Hoppe, S. A. Rosenberg, N. J. Chao, G. D. Long, B. W. Brown, and K. G. Blume. “High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial..” Blood 97, no. 2 (January 15, 2001): 404–9. https://doi.org/10.1182/blood.v97.2.404.

PMID
11154216
Full Text

Goker, H., I. C. Haznedaroglu, and N. J. Chao. “Erratum - Acute graft-vs-host disease: Pathobiology and management (Experimental Hematology (2001) 29 (259-277)).” Experimental Hematology 29, no. 5 (January 1, 2001). https://doi.org/10.1016/S0301-472X(01)00665-8.

Full Text

Ziske, C., A. Märten, B. Schöttker, P. Buttgereit, F. Schakowski, M. Gorschlüter, A. von Rücker, et al. “Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9..” Mol Ther 3, no. 1 (January 2001): 54–60. https://doi.org/10.1006/mthe.2000.0230.

PMID
11162311
Full Text

Boeckh, M., R. A. Bowden, B. Storer, N. J. Chao, R. Spielberger, D. K. Tierney, G. Gallez-Hawkins, et al. “Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation..” Biol Blood Marrow Transplant 7, no. 6 (2001): 343–51. https://doi.org/10.1016/s1083-8791(01)80005-7.

PMID
11464977
Full Text

Klein, A. K., D. D. Patel, M. E. Gooding, G. D. Sempowski, B. J. Chen, C. Liu, J. Kurtzberg, B. F. Haynes, and N. J. Chao. “T-Cell recovery in adults and children following umbilical cord blood transplantation..” Biol Blood Marrow Transplant 7, no. 8 (2001): 454–66. https://doi.org/10.1016/s1083-8791(01)80013-6.

PMID
11569891
Full Text

Pages