Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Blume, K. G., G. D. Long, R. S. Negrin, N. J. Chao, C. Kusnierz-Glaz, and M. D. Amylon. “Role of etoposide (VP-16) in preparatory regimens for patients with leukemia or lymphoma undergoing allogeneic bone marrow transplantation..” Bone Marrow Transplant 14 Suppl 4 (1994): S9-10.

PMID
7728133
Scholars@Duke

Snyder, D. S., N. J. Chao, M. D. Amylon, J. Taguchi, G. D. Long, R. S. Negrin, A. P. Nademanee, M. R. O’Donnell, G. M. Schmidt, and A. S. Stein. “Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission..” Blood 82, no. 9 (November 1, 1993): 2920–28.

PMID
8219241
Scholars@Duke

Chao, N. J., G. M. Schmidt, J. C. Niland, M. D. Amylon, A. C. Dagis, G. D. Long, A. P. Nademanee, R. S. Negrin, M. R. O’Donnell, and P. M. Parker. “Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease..” N Engl J Med 329, no. 17 (October 21, 1993): 1225–30. https://doi.org/10.1056/NEJM199310213291703.

PMID
8413388
Full Text

Schriber, J. R., R. S. Negrin, N. J. Chao, G. D. Long, S. J. Horning, and K. G. Blume. “The efficacy of granulocyte colony-stimulating factor following autologous bone marrow transplantation for non-Hodgkin's lymphoma with monoclonal antibody purged bone marrow..” Leukemia 7, no. 10 (October 1993): 1491–95.

PMID
7692189
Scholars@Duke

Chao, N. J., G. J. Berry, R. Advani, S. J. Horning, L. M. Weiss, and K. G. Blume. “Epstein-Barr virus-associated lymphoproliferative disorder following autologous bone marrow transplantation for non-Hodgkin's lymphoma..” Transplantation 55, no. 6 (June 1993): 1425–28.

PMID
8390736
Scholars@Duke

Chao, N. J., J. R. Schriber, K. Grimes, G. D. Long, R. S. Negrin, C. M. Raimondi, S. J. Horning, S. L. Brown, L. Miller, and K. G. Blume. “Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy..” Blood 81, no. 8 (April 15, 1993): 2031–35.

PMID
7682454
Scholars@Duke

Schmidt, G. M., J. C. Niland, S. J. Forman, P. P. Fonbuena, A. C. Dagis, M. M. Grant, B. R. Ferrell, T. A. Barr, B. A. Stallbaum, and N. J. Chao. “Extended follow-up in 212 long-term allogeneic bone marrow transplant survivors. Issues of quality of life..” Transplantation 55, no. 3 (March 1993): 551–57. https://doi.org/10.1097/00007890-199303000-00018.

PMID
8456476
Full Text

Chao, N. J., A. S. Stein, G. D. Long, R. S. Negrin, M. D. Amylon, R. M. Wong, S. J. Forman, and K. G. Blume. “Busulfan/etoposide--initial experience with a new preparatory regimen for autologous bone marrow transplantation in patients with acute nonlymphoblastic leukemia..” Blood 81, no. 2 (January 15, 1993): 319–23.

PMID
8422458
Scholars@Duke

Kühl, J. S., G. E. Durán, N. J. Chao, and B. I. Sikic. “Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow..” Cancer Chemother Pharmacol 33, no. 1 (1993): 10–16.

PMID
8269583
Scholars@Duke

Chao, N. J. “Graft versus host disease following allogeneic bone marrow transplantation..” Curr Opin Immunol 4, no. 5 (October 1992): 571–76.

PMID
1418721
Scholars@Duke

Pages