Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Zhang, B, Wu, J, Jiao, Y, Bock, C, Dai, M, Chen, B, Chao, N, Zhang, W, and Zhuang, Y. "Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells." Journal of immunology (Baltimore, Md. : 1950) 195, no. 9 (November 2015): 4282-4291.

PMID
26408667
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Olson, AC, Coleman, CN, Hahn, SM, DeWeese, TL, Shulman, LN, Chabner, BA, Chao, N, Martei, YM, Mundt, AJ, and Grover, S. "A Roadmap for a New Academic Pathway for Global Radiation Oncology." International journal of radiation oncology, biology, physics 93, no. 3 (November 2015): 493-496.

PMID
26460990
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Inamoto, Y, Flowers, MED, Wang, T, Urbano-Ispizua, A, Hemmer, MT, Cutler, CS, Couriel, DR, Alousi, AM, Antin, JH, Gale, RP, Gupta, V, Hamilton, BK, Kharfan-Dabaja, MA, Marks, DI, Ringdén, OTH, Socié, G, Solh, MM, Akpek, G, Cairo, MS, Chao, NJ, Hayashi, RJ, Nishihori, T, Reshef, R, Saad, A, Shah, A, Teshima, T, Tallman, MS, Wirk, B, Spellman, SR, Arora, M, and Martin, PJ. "Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21, no. 10 (October 2015): 1776-1782.

PMID
26033280
Full Text

Brenner, DJ, Chao, NJ, Greenberger, JS, Guha, C, McBride, WH, Swartz, HM, and Williams, JP. "Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network." International journal of radiation oncology, biology, physics 92, no. 3 (July 2015): 504-505.

PMID
26068482
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Tuchman, SA, Bacon, WA, Huang, L-W, Long, G, Rizzieri, D, Horwitz, M, Chute, JP, Sullivan, K, Morris Engemann, A, Yopp, A, Li, Z, Corbet, K, Chao, N, and Gasparetto, C. "Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma." Journal of Clinical Apheresis 30, no. 3 (June 2015): 176-182.

PMID
25293363
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DeBo, RJ, Register, TC, Caudell, DL, Sempowski, GD, Dugan, G, Gray, S, Owzar, K, Jiang, C, Bourland, JD, Chao, NJ, and Cline, JM. "Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques." International journal of radiation biology 91, no. 6 (June 2015): 510-518.

PMID
25786585
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Flynn, R, Allen, JL, Luznik, L, MacDonald, KP, Paz, K, Alexander, KA, Vulic, A, Du, J, Panoskaltsis-Mortari, A, Taylor, PA, Poe, JC, Serody, JS, Murphy, WJ, Hill, GR, Maillard, I, Koreth, J, Cutler, CS, Soiffer, RJ, Antin, JH, Ritz, J, Chao, NJ, Clynes, RA, Sarantopoulos, S, and Blazar, BR. "Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease." Blood 125, no. 26 (June 2015): 4085-4094.

PMID
25852057
Full Text

Musselwhite, LW, Schroeder, K, Bhattacharya, M, Vanderburg, SB, Masalu, NA, Chandy, M, Mauad, E, Bartlett, J, Kastan, MB, Merson, M, and Chao, NJA. "Duke University Global Cancer Program: A multidisciplinary approach to partnerships in global cancer care." May 20, 2015.

Scholars@Duke

Arai, S, Arora, M, Wang, T, Spellman, SR, He, W, Couriel, DR, Urbano-Ispizua, A, Cutler, CS, Bacigalupo, AA, Battiwalla, M, Flowers, ME, Juckett, MB, Lee, SJ, Loren, AW, Klumpp, TR, Prockup, SE, Ringdén, OTH, Savani, BN, Socié, G, Schultz, KR, Spitzer, T, Teshima, T, Bredeson, CN, Jacobsohn, DA, Hayashi, RJ, Drobyski, WR, Frangoul, HA, Akpek, G, Ho, VT, Lewis, VA, Gale, RP, Koreth, J, Chao, NJ, Aljurf, MD, Cooper, BW, Laughlin, MJ, Hsu, JW, Hematti, P, Verdonck, LF, Solh, MM, Norkin, M, Reddy, V, Martino, R, Gadalla, S, Goldberg, JD, McCarthy, PL, Pérez-Simón, JA, Khera, N, Lewis, ID, Atsuta, Y, Olsson, RF, Saber, W, Waller, EK, Blaise, D, Pidala, JA, Martin, PJ, Satwani, P, Bornhäuser, M, Inamoto, Y, Weisdorf, DJ, Horowitz, MM, Pavletic, SZ, and Graft-vs-Host Disease Working Committee of the CIBMTR, . "Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 21, no. 2 (February 2015): 266-274.

PMID
25445023
Full Text

Tuchman, SA, Bacon, WA, Huang, LW, Long, G, Rizzieri, D, Horwitz, M, Chute, JP, Sullivan, K, Engemann, AM, Yopp, A, Li, Z, Corbet, K, Chao, N, and Gasparetto, C. "Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma." Journal of Clinical Apheresis 30, no. 3 (January 1, 2015): 176-182.

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