Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
Phone (919) 668-1000
Email address nelson.chao@duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Chao, N. J. “Graft versus host disease following allogeneic bone marrow transplantation..” Curr Opin Immunol 4, no. 5 (October 1992): 571–76.

PMID
1418721
Scholars@Duke

Chao, N. J., D. K. Tierney, J. R. Bloom, G. D. Long, T. A. Barr, B. A. Stallbaum, R. M. Wong, R. S. Negrin, S. J. Horning, and K. G. Blume. “Dynamic assessment of quality of life after autologous bone marrow transplantation..” Blood 80, no. 3 (August 1, 1992): 825–30.

PMID
1638031
Scholars@Duke

Chao, N. J., G. D. Long, R. S. Negrin, J. R. Schriber, C. M. Raimondi, S. L. Brown, and K. G. Blume. “G-CSF and peripheral blood progenitor cells..” Lancet 339, no. 8806 (June 6, 1992).

PMID
1375969
Scholars@Duke

Marie, J. P., N. A. Brophy, M. N. Ehsan, Y. Aihara, N. A. Mohamed, J. Cornbleet, N. J. Chao, and B. I. Sikic. “Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells..” Br J Haematol 81, no. 2 (June 1992): 145–52. https://doi.org/10.1111/j.1365-2141.1992.tb08199.x.

PMID
1353683
Full Text

Advani, R., N. J. Chao, S. J. Horning, K. G. Blume, D. K. Ahn, K. R. Lamborn, N. C. Fleming, E. M. Bonnem, and P. L. Greenberg. “Granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjunct to autologous hemopoietic stem cell transplantation for lymphoma..” Ann Intern Med 116, no. 3 (February 1, 1992): 183–89. https://doi.org/10.7326/0003-4819-116-3-183.

PMID
1345803
Full Text

Chao, N. J., M. Aihara, J. S. Kühl, B. I. Sikic, and K. G. Blume. “Purging multidrug resistant cells from bone marrow..” Prog Clin Biol Res 377 (1992): 13–23.

PMID
1438409
Scholars@Duke

Kühl, J. S., B. I. Sikic, K. G. Blume, and N. J. Chao. “Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model..” Prog Clin Biol Res 377 (1992): 25–34.

PMID
1438422
Scholars@Duke

Chao, N. J., S. J. Forman, G. M. Schmidt, D. S. Snyder, M. D. Amylon, P. N. Konrad, A. P. Nademanee, M. R. O’Donnell, P. M. Parker, and A. S. Stein. “Allogeneic bone marrow transplantation for high-risk acute lymphoblastic leukemia during first complete remission..” Blood 78, no. 8 (October 15, 1991): 1923–27.

PMID
1912575
Scholars@Duke

Forman, S. J., G. M. Schmidt, A. P. Nademanee, M. D. Amylon, N. J. Chao, J. L. Fahey, P. N. Konrad, K. A. Margolin, J. C. Niland, and M. R. O’Donnell. “Allogeneic bone marrow transplantation as therapy for primary induction failure for patients with acute leukemia..” J Clin Oncol 9, no. 9 (September 1991): 1570–74. https://doi.org/10.1200/JCO.1991.9.9.1570.

PMID
1875218
Full Text

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