Nelson Jen An Chao, MD

Professor of Medicine
Donald D. and Elizabeth G. Cooke Cancer Research Professor
Professor in Immunology
ResearchProfessor of Global Health
Professor in Pathology
Member of the Duke Cancer Institute
Chief, Division of Cell Therapy in the Department of Medicine
Affiliate of the Regeneration Next Initiative
Campus mail 1146 N Pavilion, Durham, NC 27710
Phone (919) 668-1011
Email address chao0002@mc.duke.edu

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

For more information see http://ed-media.mc.duke.edu/BMT.nsf

In Their Words

Education and Training

  • Fellow in Oncology, Medicine, Stanford University, 1985 - 1987
  • Medical Resident, Medicine, Stanford University, 1981 - 1984
  • M.D., Yale University, 1981

Publications

Chao, NJ, Duncan, SR, Long, GD, Horning, SJ, and Blume, KG. "Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients." Ann Intern Med 114, no. 2 (January 15, 1991): 145-146.

PMID
1984392
Scholars@Duke

Horning, SJ, Chao, NJ, Negrin, RS, Hoppe, RT, Kwak, LW, Long, GD, Stallbaum, B, O'Connor, P, and Blume, KG. "The Stanford experience with high-dose etoposide cytoreductive regimens and autologous bone marrow transplantation in Hodgkin's disease and non-Hodgkin's lymphoma: Preliminary data." January 1, 1991.

Scholars@Duke

Horning, SJ, Chao, NJ, Negrin, RS, Hoppe, RT, Kwak, LW, Long, GD, Stallbaum, B, O'Connor, P, and Blume, KG. "The Stanford experience with high-dose etoposide cytoreductive regimens and autologous bone marrow transplantation in Hodgkin's disease and non-Hodgkin's lymphoma: preliminary data." Ann Oncol 2 Suppl 1 (January 1991): 47-50.

PMID
2043498
Scholars@Duke

Schmidt, GM, Horak, DA, Niland, JC, Duncan, SR, Forman, SJ, Zaia, JA, Hogan, JM, Faucett, C, Hill, LR, Wall, FJ, Gallez-Hawkins, G, Morton-Blackshere, A, Nademanee, AP, O'Donnell, MR, Parker, P, Snyder, DS, Smith, E, Stein, A, Margolin, K, Somlo, G, Kovacs, AA, Chao, NJ, Blume, KG, DeArmond, B, Buhles, W, DuMond, C, and Sullivan, V. "A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants." New England Journal of Medicine 324, no. 15 (1991): 1005-1011.

Scholars@Duke

Chao, NJ, Aihara, M, Blume, KG, and Sikic, BI. "Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow." Exp Hematol 18, no. 11 (December 1990): 1193-1198.

PMID
2226679
Scholars@Duke

Chao, NJ, Rosenberg, SA, and Horning, SJ. "CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma." Blood 76, no. 7 (October 1, 1990): 1293-1298.

PMID
2207307
Scholars@Duke

Chao, NJ, and Blume, KG. "Bone marrow transplantation: what is the question?." Ann Intern Med 113, no. 5 (September 1, 1990): 340-341.

PMID
2382915
Scholars@Duke

Aihara, M, Sikic, BI, Blume, KG, and Chao, NJ. "Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture." Exp Hematol 18, no. 8 (September 1990): 940-944.

PMID
2387345
Scholars@Duke

Chao, NJ, and Blume, KG. "Bone marrow transplantation. Part II--autologous." West J Med 152, no. 1 (January 1990): 46-51. (Review)

PMID
2408234
Scholars@Duke

Blume, KG, Schmidt, GM, Chao, NJ, and Forman, SJ. "Bone marrow transplantation from histocompatible sibling donors for patients with acute lymphoblastic leukemia." Haematol Blood Transfus 33 (1990): 636-637.

PMID
2323664
Scholars@Duke

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