Nishad Jayasundara, PhD

Assistant Professor of Environmental Toxicology and Health
Assistant Research Professor of Global Health
Assistant Professor in Medicine
Email address nj58@duke.edu

Dr. Jayasundara studies adverse ecological and human health outcomes of anthropogenic environmental change. Specifically, Dr. Jayasundara focuses on various teleost fish species (e.g., zebrafish Danio rerio  and Atlantic killifish Fundulus heteroclitus) and conduct field and laboratory studies that integrate functional genomics analyses, in vitro and in vivo physiological and biochemical assays, and mathematical modeling approaches. Ongoing projects aim to:

1. Determine interactive effects of metals and pesticides on kidney mitochondrial function in the context of chronic kidney disease epidemic in agricultural communities based on environmental epidemiology and mechanistic toxicology studies.

2. Examine mitochondrial responses to acute and chronic exposure to heat stress during organismal development and linking to later-life metabolic consequences 

3. Elucidate the role of genetic, epigenetic, and gut microbiome shifts in evolved resistance to chemical pollutants.  

4. Assess rural water quality through citizen science and community engagement in Maine and Sri Lanka

Education and Training

  • Ph.D., Stanford University, 2012

Publications

Sandamini, Patabandi Maddumage Mihiri Ayesha, Pallage Mangala Chathura Surendra De Silva, Thibbotuwa Deniya Kankanamge Sameera Chathuranga Gunasekara, Sakuntha Dewaka Gunarathna, Ranawake Arachchige Isini Pinipa, Chula Herath, Sudheera Sammanthi Jayasinghe, Ediriweera Patabandi Saman Chandana, and Nishad Jayasundara. “Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka.” World Journal of Pediatrics : Wjp 18, no. 3 (March 2022): 196–205. https://doi.org/10.1007/s12519-022-00513-9.

PMID
35107783
Full Text

Zhang, J., M. Zhang, N. Jayasundara, X. Ren, B. Gao, P. Liu, J. Li, and X. Meng. “Physiological and Molecular Responses in the Gill of the Swimming Crab Portunus trituberculatus During Long-Term Ammonia Stress.” Frontiers in Marine Science 8 (December 9, 2021). https://doi.org/10.3389/fmars.2021.797241.

Full Text

Meng, Xianliang, Nishad Jayasundara, Jingyan Zhang, Xianyun Ren, Baoquan Gao, Jian Li, and Ping Liu. “Integrated physiological, transcriptome and metabolome analyses of the hepatopancreas of the female swimming crab Portunus trituberculatus under ammonia exposure.” Ecotoxicology and Environmental Safety 228 (November 25, 2021): 113026. https://doi.org/10.1016/j.ecoenv.2021.113026.

PMID
34839137
Full Text

Babich, Remy, Emily Craig, Abigail Muscat, Jane Disney, Anna Farrell, Linda Silka, and Nishad Jayasundara. “Defining drinking water metal contaminant mixture risk by coupling zebrafish behavioral analysis with citizen science.” Scientific Reports 11, no. 1 (August 27, 2021): 17303. https://doi.org/10.1038/s41598-021-96244-4.

PMID
34453073
Full Text

De Silva, P Mangala C. S., T. D. K. S. C. Gunasekara, S. D. Gunarathna, P. M. M. A. Sandamini, R. A. I. Pinipa, E. M. D. V. Ekanayake, W. A. K. G. Thakshila, S. S. Jayasinghe, E. P. S. Chandana, and Nishad Jayasundara. “Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka.” Children (Basel, Switzerland) 8, no. 8 (August 9, 2021): 684. https://doi.org/10.3390/children8080684.

PMID
34438575
Full Text

Redfern, Lauren K., Nishad Jayasundara, David R. Singleton, Richard T. Di Giulio, James Carlson, Susan J. Sumner, and Claudia K. Gunsch. “The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons.” The Science of the Total Environment 776 (July 2021): 145955. https://doi.org/10.1016/j.scitotenv.2021.145955.

PMID
33647645
Full Text

Abdul, K. S. M., P Mangala C. S. De Silva, E. M. D. V. Ekanayake, W. A. K. G. Thakshila, S. D. Gunarathna, T. D. K. S. C. Gunasekara, S. S. Jayasinghe, et al. “Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka.” International Journal of Environmental Research and Public Health 18, no. 6 (March 22, 2021): 3278. https://doi.org/10.3390/ijerph18063278.

PMID
33810013
Full Text

Gans, Ian M., Janelle Grendler, Remy Babich, Nishad Jayasundara, and James A. Coffman. “Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism.” Frontiers in Cell and Developmental Biology 9 (January 2021): 727037. https://doi.org/10.3389/fcell.2021.727037.

PMID
34692682
Full Text

Gearhart-Serna, Larisa M., John B. Davis, Mohit Kumar Jolly, Nishad Jayasundara, Scott J. Sauer, Richard T. Di Giulio, and Gayathri R. Devi. “A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.” Carcinogenesis 41, no. 12 (December 31, 2020): 1648–59. https://doi.org/10.1093/carcin/bgaa047.

PMID
32747956
Full Text

Gunasekara, T. D. K. S. C., P Mangala C. S. De Silva, Chula Herath, Sisira Siribaddana, Nipuna Siribaddana, Channa Jayasumana, Sudheera Jayasinghe, Maria Cardenas-Gonzalez, and Nishad Jayasundara. “The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.” International Journal of Environmental Research and Public Health 17, no. 24 (December 18, 2020): E9522. https://doi.org/10.3390/ijerph17249522.

PMID
33353238
Full Text

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