P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is professor of psychiatry and professor in medicine at the Duke University School of Medicine where he is a highly respected physician neuroscientist at the Duke Institute for Brain Sciences. He specializes in the areas of brain health and personalized medicine and leads a clinical trials unit in developing novel personal diagnostics and therapeutics for cognitive enhancement and mental well-being. Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and lectured at leading global forums to advance the forefront of neuroscience research.  Moreover as co-author of a popular book The Alzheimer’s Action Plan and co-author on more than 350 publications, he has received several awards in recognition of his scientific work and his involvement in pivotal landmark trials that have helped develop many modern neurotherapeutics. Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain.

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Privitera, Gregory J., Deeanna Welling, Gabriela Tejada, Nicole Sweazy, Kayla N. Cuifolo, Quentin W. King-Shepard, and P Murali Doraiswamy. “No calorie comfort: Viewing and drawing "comfort foods" similarly augment positive mood for those with depression.” J Health Psychol 23, no. 4 (March 2018): 598–607. https://doi.org/10.1177/1359105316681861.

PMID
27956477
Full Text

Varma, Vijay R., Anup M. Oommen, Sudhir Varma, Ramon Casanova, Yang An, Ryan M. Andrews, Richard O’Brien, et al. “Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.” Plos Med 15, no. 1 (January 2018): e1002482. https://doi.org/10.1371/journal.pmed.1002482.

PMID
29370177
Full Text

Doraiswamy, P Murali, Vaibhav A. Narayan, and Husseini K. Manji. “Mobile and pervasive computing technologies and the future of Alzheimer's clinical trials.” Npj Digit Med 1 (2018): 1. https://doi.org/10.1038/s41746-017-0008-y.

PMID
31304287
Full Text

Padmanabhan, K., K. Nudelman, S. Harenberg, G. Bello, D. Sohn, K. Shpanskaya, P. T. Dikshit, et al. “Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach.” Processes 5, no. 3 (September 1, 2017). https://doi.org/10.3390/pr5030047.

Full Text

Toledo, Jon B., Matthias Arnold, Gabi Kastenmüller, Rui Chang, Rebecca A. Baillie, Xianlin Han, Madhav Thambisetty, et al. “Metabolic network failures in Alzheimer's disease: A biochemical road map.” Alzheimers Dement 13, no. 9 (September 2017): 965–84. https://doi.org/10.1016/j.jalz.2017.01.020.

PMID
28341160
Full Text

Singanamalli, Asha, Haibo Wang, Anant Madabhushi, and Anant Alzheimer’s Disease Neuroimaging Initiative. “Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.” Sci Rep 7, no. 1 (August 15, 2017): 8137. https://doi.org/10.1038/s41598-017-03925-0.

PMID
28811553
Full Text

Gamberger, Dragan, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, and P Murali Doraiswamy. “Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease.” Sci Rep 7, no. 1 (July 28, 2017): 6763. https://doi.org/10.1038/s41598-017-06624-y.

PMID
28755001
Full Text

Mattsson, Niklas, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, and Kaj Alzheimer’s Disease Neuroimaging Initiative. “Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.” Jama Neurol 74, no. 5 (May 1, 2017): 557–66. https://doi.org/10.1001/jamaneurol.2016.6117.

PMID
28346578
Full Text

Lin, Katherine Amy, Colin Rundel, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment.” J Alzheimers Dis 55, no. 3 (2017): 1123–30. https://doi.org/10.3233/JAD-160513.

PMID
27767986
Full Text

Lee, Eunjee, Kelly S. Giovanello, Andrew J. Saykin, Fengchang Xie, Dehan Kong, Yue Wang, Liuqing Yang, Joseph G. Ibrahim, P Murali Doraiswamy, and Hongtu Zhu. “Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.” Alzheimers Dement (Amst) 8 (2017): 86–95. https://doi.org/10.1016/j.dadm.2017.04.004.

PMID
28560309
Full Text

Pages