P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Director, Neurocognitive Disorders Program
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Duke Initiative for Science & Society
Campus mail 3550 Hosp South, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is professor of psychiatry and professor in medicine at the Duke University School of Medicine where he is a highly respected physician neuroscientist at the Duke Institute for Brain Sciences. He specializes in the areas of brain health and personalized medicine and leads a clinical trials unit in developing novel personal diagnostics and therapeutics for cognitive enhancement and mental well-being. Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and lectured at leading global forums to advance the forefront of neuroscience research.  Moreover as co-author of a popular book The Alzheimer’s Action Plan and co-author on more than 350 publications, he has received several awards in recognition of his scientific work and his involvement in pivotal landmark trials that have helped develop many modern neurotherapeutics. Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain.

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Grants

Publications

Kaddurah-Daouk, R., H. Zhu, S. Sharma, M. Bogdanov, S. G. Rozen, W. Matson, N. O. Oki, et al. “Alterations in metabolic pathways and networks in Alzheimer's disease.” Transl Psychiatry 3 (April 9, 2013): e244. https://doi.org/10.1038/tp.2013.18.

PMID
23571809
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Hochstetler, Helen, P Murali Doraiswamy, Reisa A. Sperling, Keith A. Johnson, Eric Reiman, Marwan N. Sabbagh, Carl H. Sadowsky, et al. “Relationship of Florbetapir F18 PET Amyloid Plaque Neuroimaging with Future Cognitive Decline over 36 Months.” In The American Journal of Geriatric Psychiatry, 21:S136–S136. Elsevier BV, 2013. https://doi.org/10.1016/j.jagp.2012.12.180.

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Witte, Michael, Brittany Dugger, Geidy Serrano, Barry J. Bedell, P Murali Doraiswamy, Adam S. Fleisher, Eric Reiman, et al. “Florbetapir PET Imaging Predicts Postmortem Amyloid Burden in Alzheimer's Disease Despite Presence of Other Neuropathologies.” In The American Journal of Geriatric Psychiatry, 21:S138–39. Elsevier BV, 2013. https://doi.org/10.1016/j.jagp.2012.12.183.

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Sperling, Reisa A., Keith A. Johnson, P Murali Doraiswamy, Eric M. Reiman, Adam S. Fleisher, Marwan N. Sabbagh, Carl H. Sadowsky, et al. “Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.” Neurobiol Aging 34, no. 3 (March 2013): 822–31. https://doi.org/10.1016/j.neurobiolaging.2012.06.014.

PMID
22878163
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Tariot, P. N., and P. M. Doraiswamy. “Alzheimer's disease: the importance of early diagnosis and appropriate management.” J Clin Psychiatry 74, no. 3 (March 2013): e06. https://doi.org/10.4088/JCP.12062wc1.

PMID
23561238
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Shaffer, Jennifer L., Jeffrey R. Petrella, Forrest C. Sheldon, Kingshuk Roy Choudhury, Vince D. Calhoun, R Edward Coleman, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers.” Radiology 266, no. 2 (February 2013): 583–91. https://doi.org/10.1148/radiol.12120010.

PMID
23232293
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Blumenthal, James A., Patrick J. Smith, Kathleen Welsh-Bohmer, Michael A. Babyak, Jeffrey Browndyke, Pao-Hwa Lin, P Murali Doraiswamy, et al. “Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.” Contemp Clin Trials 34, no. 1 (January 2013): 60–69. https://doi.org/10.1016/j.cct.2012.09.004.

PMID
23000080
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Fleisher, Adam S., Kewei Chen, Xiaofen Liu, Napatkamon Ayutyanont, Auttawut Roontiva, Pradeep Thiyyagura, Hillary Protas, et al. “Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease.” Neurobiol Aging 34, no. 1 (January 2013): 1–12. https://doi.org/10.1016/j.neurobiolaging.2012.04.017.

PMID
22633529
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