Patty J Lee, MD

Professor of Medicine
Professor of Cell Biology
Professor in Pathology
Campus mail 3110 MSRB 3, 3 Genome Court, Durham, NC 27710
Phone (919) 684-0928
Email address patty.lee@duke.edu

My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system.  Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.

Education and Training

  • Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine, 1994 - 1998
  • Internal Medicine Residency, Johns Hopkins University School of Medicine, 1991 - 1994
  • M.D., Brown University, 1991

Publications

Clapham, Katharine R., Youlan Rao, Sandeep Sahay, Maor Sauler, Patty J. Lee, Mitchell A. Psotka, Wassim H. Fares, and Tariq Ahmad. “PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension.” Am J Cardiol 127 (July 15, 2020): 198–99. https://doi.org/10.1016/j.amjcard.2020.04.031.

PMID
32430164
Full Text

Kim, S., F. Wan, X. Zhang, Y. Zhang, E. Ifedigbo, L. Leng, R. Bucala, P. Lee, and M. Sauler. “MIF-CD74 Signaling Protects Against Endothelial Senescence in Chronic Obstructive Pulmonary Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.

Scholars@Duke

Lindow, Janet C., Annie J. Tsay, Ruth R. Montgomery, Eliana A. G. Reis, Elsio A. Wunder, Guilherme Araújo, Nivison R. R. Nery, et al. “Elevated Activation of Neutrophil Toll-Like Receptors in Patients with Acute Severe Leptospirosis: An Observational Study.” Am J Trop Med Hyg 101, no. 3 (September 2019): 585–89. https://doi.org/10.4269/ajtmh.19-0160.

PMID
31333152
Full Text

Kim, So-Jin, Peiying Shan, Cheol Hwangbo, Yi Zhang, Jin-Na Min, Xuchen Zhang, Taylor Ardito, et al. “Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.” Aging Cell 18, no. 3 (June 2019): e12914. https://doi.org/10.1111/acel.12914.

PMID
30790400
Full Text

Zhang, Yi, Peiying Shan, Anup Srivastava, Zhenyu Li, and Patty J. Lee. “Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4.” Antioxid Redox Signal 30, no. 15 (May 20, 2019): 1775–96. https://doi.org/10.1089/ars.2018.7514.

PMID
30187766
Full Text

Zhang, C., C. Ramsey, A. Berical, L. Yu, L. Leng, K. A. McGinnis, Y. Song, et al. “A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.” Am J Physiol Lung Cell Mol Physiol 316, no. 2 (February 1, 2019): L400–405. https://doi.org/10.1152/ajplung.00439.2018.

PMID
30520689
Full Text

Pellowe, Amanda S., Maor Sauler, Yue Hou, Jonathan Merola, Rebecca Liu, Brenda Calderon, Holly M. Lauridsen, et al. “Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.” Faseb J 33, no. 2 (February 2019): 2171–86. https://doi.org/10.1096/fj.201800480R.

PMID
30252532
Full Text

Belsky, Justin B., Charles R. Wira, Vinitha Jacob, John E. Sather, and Patty J. Lee. “A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.” Nutr Res Rev 31, no. 2 (December 2018): 281–90. https://doi.org/10.1017/S0954422418000124.

PMID
29984680
Full Text

Wang, Chaoqun, Nabora S Reyes de Mochel, Stephanie A. Christenson, Monica Cassandras, Rebecca Moon, Alexis N. Brumwell, Lauren E. Byrnes, et al. “Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.” J Clin Invest 128, no. 10 (October 1, 2018): 4343–58. https://doi.org/10.1172/JCI99435.

PMID
29999500
Full Text

Pages