Paul Grimsrud, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 104775, Durham, NC 27701
Phone (919) 684-0631
Email address paul.grimsrud@duke.edu

Paul Grimsrud is an Assistant professor of Medicine—in the Division of Endocrinology, Metabolism, and Nutrition—and Proteomics Section Leader at the Duke Molecular Physiology Institute. He completed a PhD in Biochemistry at the University of Minnesota-Twin Cities and a postdoctoral fellowship at the University of Wisconsin-Madison. His research combines mass spectrometry-based proteomics with complementary biochemical approaches to characterize the regulation of metabolism and signaling by protein post-translational modifications (PTMs). He is particularly interested in mechanisms that link altered mitochondrial function to metabolic diseases, such as heart failure, type 2 diabetes, and cancer. He works with colleagues to apply quantitative PTM measurements to relevant model systems, leverage bioinformatics tools to develop testable hypotheses from large-scale data, and characterize mechanisms of PTM-mediated metabolic control.

Education and Training

  • Ph.D., University of Minnesota, Twin Cities, 2008

Publications

Grimsrud, Paul A., Joshua J. Carson, Alex S. Hebert, Shane L. Hubler, Natalie M. Niemi, Derek J. Bailey, Adam Jochem, et al. “A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.” Cell Metab 16, no. 5 (November 7, 2012): 672–83. https://doi.org/10.1016/j.cmet.2012.10.004.

PMID
23140645
Full Text

Volkening, Jeremy D., Derek J. Bailey, Christopher M. Rose, Paul A. Grimsrud, Maegen Howes-Podoll, Muthusubramanian Venkateshwaran, Michael S. Westphall, Jean-Michel Ané, Joshua J. Coon, and Michael R. Sussman. “A proteogenomic survey of the Medicago truncatula genome.” Mol Cell Proteomics 11, no. 10 (October 2012): 933–44. https://doi.org/10.1074/mcp.M112.019471.

PMID
22774004
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Rose, Christopher M., Muthusubramanian Venkateshwaran, Jeremy D. Volkening, Paul A. Grimsrud, Junko Maeda, Derek J. Bailey, Kwanghyun Park, et al. “Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosis.” Mol Cell Proteomics 11, no. 9 (September 2012): 724–44. https://doi.org/10.1074/mcp.M112.019208.

PMID
22683509
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Jayaraman, Dhileepkumar, Kari L. Forshey, Paul A. Grimsrud, and Jean-Michel Ané. “Leveraging proteomics to understand plant-microbe interactions.” Front Plant Sci 3 (2012): 44. https://doi.org/10.3389/fpls.2012.00044.

PMID
22645586
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Rose, Christopher M., Muthusubramanian Venkateshwaran, Paul A. Grimsrud, Michael S. Westphall, Michael R. Sussman, Joshua J. Coon, and Jean-Michel Ané. “Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data.” Front Plant Sci 3 (2012): 122. https://doi.org/10.3389/fpls.2012.00122.

PMID
22701463
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Hellberg, Kristina, Paul A. Grimsrud, Andrew C. Kruse, Leonard J. Banaszak, Douglas H. Ohlendorf, and David A. Bernlohr. “X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.” Protein Sci 19, no. 8 (August 2010): 1480–89. https://doi.org/10.1002/pro.427.

PMID
20509169
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Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.

PMID
20150287
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Grimsrud, Paul A., Danielle L. Swaney, Craig D. Wenger, Nicole A. Beauchene, and Joshua J. Coon. “Phosphoproteomics for the masses.” Acs Chem Biol 5, no. 1 (January 15, 2010): 105–19. https://doi.org/10.1021/cb900277e.

PMID
20047291
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Grimsrud, Paul A., Désirée den Os, Craig D. Wenger, Danielle L. Swaney, Daniel Schwartz, Michael R. Sussman, Jean-Michel Ané, and Joshua J. Coon. “Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes.” Plant Physiol 152, no. 1 (January 2010): 19–28. https://doi.org/10.1104/pp.109.149625.

PMID
19923235
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Grimsrud, Paul A., Hongwei Xie, Timothy J. Griffin, and David A. Bernlohr. “Oxidative stress and covalent modification of protein with bioactive aldehydes.” J Biol Chem 283, no. 32 (August 8, 2008): 21837–41. https://doi.org/10.1074/jbc.R700019200.

PMID
18445586
Full Text

Pages