Phillip James White, PhD

Assistant Professor in Medicine
Assistant Research Professor in Pharmacology and Cancer Biology
Member of Duke Molecular Physiology Institute
Email address phillip.white@duke.edu

Phillip White is an Assistant Professor in the Department of Medicine, Division of Endocrinology, Metabolism and Nutrition. Phillip Co-Leads the White-McGarrah Lab with Robert McGarrah at the Duke Molecular Physiology Institue. Projects in the White-McGarrah Lab relate to the integrative physiology of metabolism with an emphasis on liver and heart function and the metabolic crosstalk that exists between these two vital organs.

Education and Training

  • Ph.D., Universite Laval (Canada), 2012

Publications

Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing..” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.

PMID
31534056
Full Text

Hung, Yu-Han, Matt Kanke, C Lisa Kurtz, Rebecca Cubitt, Rodica P. Bunaciu, Ji Miao, Liye Zhou, et al. “Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice..” Physiol Genomics 51, no. 8 (August 1, 2019): 379–89. https://doi.org/10.1152/physiolgenomics.00037.2019.

PMID
31251698
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Yoneshiro, Takeshi, Qiang Wang, Kazuki Tajima, Mami Matsushita, Hiroko Maki, Kaori Igarashi, Zhipeng Dai, et al. “BCAA catabolism in brown fat controls energy homeostasis through SLC25A44..” Nature 572, no. 7771 (August 2019): 614–19. https://doi.org/10.1038/s41586-019-1503-x.

PMID
31435015
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Ericksen, Russell E., Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J. White, Zhaobing Ding, et al. “Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression..” Cell Metab 29, no. 5 (May 7, 2019): 1151-1165.e6. https://doi.org/10.1016/j.cmet.2018.12.020.

PMID
30661928
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White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase..” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

PMID
29779826
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Gurley, Jami M., Olga Ilkayeva, Robert M. Jackson, Beth A. Griesel, Phillip White, Satochi Matsuzaki, Rizwan Qaisar, et al. “Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism..” Diabetes 65, no. 12 (December 2016): 3585–97. https://doi.org/10.2337/db16-0709.

PMID
27679559
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White, Phillip J., Amanda L. Lapworth, Jie An, Liping Wang, Robert W. McGarrah, Robert D. Stevens, Olga Ilkayeva, et al. “Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export..” Mol Metab 5, no. 7 (July 2016): 538–51. https://doi.org/10.1016/j.molmet.2016.04.006.

PMID
27408778
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Vandal, Milene, Philip J. White, Marine Tournissac, Cyntia Tremblay, Isabelle St-Amour, Janelle Drouin-Ouellet, Melanie Bousquet, et al. “Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease..” Neurobiol Aging 43 (July 2016): 47–57. https://doi.org/10.1016/j.neurobiolaging.2016.03.024.

PMID
27255814
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Glynn, Erin L., Lucy W. Piner, Kim M. Huffman, Cris A. Slentz, Lorraine Elliot-Penry, Hiba AbouAssi, Phillip J. White, et al. “Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans..” Diabetologia 58, no. 10 (October 2015): 2324–35. https://doi.org/10.1007/s00125-015-3705-6.

PMID
26254576
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