Redford B. Williams, MD

Professor of Psychiatry and Behavioral Sciences
Professor of Psychology and Neuroscience
Professor of Medicine
Campus mail 905 W. Main Street, Suite 22 (2nd Floor), Durham, NC 27701
Phone (919) 684-3863
Email address redfordw@duke.edu

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Education and Training

  • M.D., Yale University, 1967

Publications

Williams, Redford B., George D. Bishop, Brett C. Haberstick, Andrew Smolen, Beverly H. Brummett, Ilene C. Siegler, Michael A. Babyak, et al. “Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.” Am Heart J 185 (March 2017): 110–22. https://doi.org/10.1016/j.ahj.2016.12.013.

PMID
28267464
Full Text

Feigal, Jacob P., Stephen H. Boyle, Zainab Samad, Eric J. Velazquez, Jennifer L. Wilson, Richard C. Becker, Redford B. Williams, et al. “Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.” J Psychosom Res 93 (February 2017): 14–18. https://doi.org/10.1016/j.jpsychores.2016.11.012.

PMID
28107887
Full Text

Jiang, Rong, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Abanish Singh, Ilene C. Siegler, Svati H. Shah, Carol Haynes, Megan Chryst-Ladd, and Redford B. Williams. “Brain-Derived Neurotrophic Factor Val66Met Variants (RS6265) are Associated with Coronary Heart Disease (CHD) Outcomes in a Patient Sample.” In Genetic Epidemiology, 40:643–643. WILEY-BLACKWELL, 2016.

Scholars@Duke

Singh, Abanish, Elizabeth R. Hauser, Johanna L. Johnson, Michael A. Babyak, Beverly H. Brummett, Rong Jiang, Cris A. Slentz, et al. “Follow-up of GxE Interactions: EBF1 GxE Association, Synthetic Chronic Psychosocial Stress, and Dropout from a Structured Exercise Program.” In Genetic Epidemiology, 40:662–63. WILEY-BLACKWELL, 2016.

Scholars@Duke

Haberstick, Brett C., Jason D. Boardman, Brandon Wagner, Andrew Smolen, John K. Hewitt, Ley A. Killeya-Jones, Joyce Tabor, et al. “Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).” Plos One 11, no. 3 (2016): e0148373. https://doi.org/10.1371/journal.pone.0148373.

PMID
26938215
Full Text

Singh, Abanish, Michael A. Babyak, Beverly H. Brummett, Rong Jiang, Lana L. Watkins, John C. Barefoot, William E. Kraus, et al. “Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.” Genet Epidemiol 39, no. 6 (September 2015): 489–97. https://doi.org/10.1002/gepi.21910.

PMID
26202568
Full Text

Boyle, Stephen H., Wayne R. Matson, Eric J. Velazquez, Zainab Samad, Redford B. Williams, Swati Sharma, Beena Thomas, Jennifer L. Wilson, Christopher O’Connor, and Wei Jiang. “Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction.” Metabolomics 11, no. 3 (June 1, 2015): 571–82. https://doi.org/10.1007/s11306-014-0718-y.

PMID
25983674
Full Text

Singh, Abanish, Michael A. Babyak, Daniel K. Nolan, Beverly H. Brummett, Rong Jiang, Ilene C. Siegler, William E. Kraus, Svati H. Shah, Redford B. Williams, and Elizabeth R. Hauser. “Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.” Eur J Hum Genet 23, no. 6 (June 2015): 854–62. https://doi.org/10.1038/ejhg.2014.189.

PMID
25271088
Full Text

Jiang, Wei, Stephen H. Boyle, Thomas L. Ortel, Zainab Samad, Eric J. Velazquez, Robert W. Harrison, Jennifer Wilson, et al. “Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.” Am Heart J 169, no. 4 (April 2015): 496-507.e1. https://doi.org/10.1016/j.ahj.2014.12.002.

PMID
25819856
Full Text

Pages