Robert John Mentz, MD

Associate Professor of Medicine
Associate Professor in Population Health Sciences
Member in the Duke Clinical Research Institute
Campus mail Np-8062, Dcri. PO Box 17969, Durham, NC 27715
Phone (919) 668-7121
Email address

I am a cardiologist with a clinical and research interest in heart failure, including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps." I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.

My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:

  •     Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure.
  •     Phenotypic characterization and risk prognostication of patients with heart failure.
  •     Role of surrogate and nonfatal endpoints in clinical heart failure trials.
  •     Biomarkers in heart failure.
  •     Novel pharmacological and non-pharmacological approaches to heart failure.
  •     Improving site-based heart failure research.
In Their Words

Education and Training

  • Fellowship, Advanced Heart Failure, Duke University School of Medicine, 2012 - 2013
  • Fellowship, Clinical Cardiology, Duke University School of Medicine, 2010 - 2012
  • Resident, Internal Medicine, Brigham and Women's Hospital, 2008 - 2010
  • Intern, Internal Medicine, Brigham and Women's Hospital, 2007 - 2008
  • M.D., Emory University, 2003


Clark, Donald, Loretta R. Cain, Michael J. Blaha, Andrew P. DeFilippis, Robert J. Mentz, Daisuke Kamimura, Wendy B. White, et al. “Cigarette Smoking and Subclinical Peripheral Arterial Disease in Blacks of the Jackson Heart Study..” J Am Heart Assoc 8, no. 3 (February 5, 2019).

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Luo, Nancy, Steven J. Lippmann, Robert J. Mentz, Melissa A. Greiner, Bradley G. Hammill, N Chantelle Hardy, Warren K. Laskey, et al. “Relationship Between Hospital Characteristics and Early Adoption of Angiotensin-Receptor/Neprilysin Inhibitor Among Eligible Patients Hospitalized for Heart Failure..” J Am Heart Assoc 8, no. 3 (February 5, 2019).

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Goldstein, Sarah A., Robert J. Mentz, Anne S. Hellkamp, Tiffany C. Randolph, Gregg C. Fonarow, Adrian Hernandez, Clyde W. Yancy, and Sana M. Al-Khatib. “Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes..” Clin Cardiol 42, no. 2 (February 2019): 256–63.

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Clegg, Lindsay E., Hiddo J. L. Heerspink, Robert C. Penland, Weifeng Tang, David W. Boulton, Srinivas Bachina, Robert D. Fox, et al. “Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL..” Diabetes Care 42, no. 2 (February 2019): 318–26.

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Pandey, Ambarish, Neil Keshvani, Colby Ayers, Adolfo Correa, Mark H. Drazner, Alana Lewis, Carlos J. Rodriguez, et al. “Association of Cardiac Injury and Malignant Left Ventricular Hypertrophy With Risk of Heart Failure in African Americans: The Jackson Heart Study..” Jama Cardiol 4, no. 1 (January 1, 2019): 51–58.

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Luo, Nancy, Christopher M. O’Connor, Lauren B. Cooper, Jie-Lena Sun, Adrian Coles, Shelby D. Reed, David J. Whellan, Ileana L. Piña, William E. Kraus, and Robert J. Mentz. “Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION..” Eur J Heart Fail 21, no. 1 (January 2019): 63–70.

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Warraich, Haider J., Donald H. Taylor, David J. Casarett, Marisette Hasan, Chetan B. Patel, Arif H. Kamal, Matthew Harker, and Robert J. Mentz. “Hospice Care for Heart Failure: Challenges Faced by Hospice Staff in a Predominantly Rural Setting..” J Palliat Med 22, no. 1 (January 2019): 7–8.

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Eisenstein, Eric L., Kristi Prather, Stephen J. Greene, Tina Harding, Amanda Harrington, Davera Gabriel, Ingrid Jones, Robert J. Mentz, Eric J. Velazquez, and Kevin J. Anstrom. “Death: The Simple Clinical Trial Endpoint..” Stud Health Technol Inform 257 (2019): 86–91.


Fudim, Marat, Andrew P. Ambrosy, Jie-Lena Sun, Kevin J. Anstrom, Bradley A. Bart, Javed Butler, Omar AbouEzzeddine, et al. “High-Sensitivity Troponin I in Hospitalized and Ambulatory Patients With Heart Failure With Preserved Ejection Fraction: Insights From the Heart Failure Clinical Research Network..” In J Am Heart Assoc, Vol. 7, 2018.

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