Robert M. Califf

Adjunct Professor of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.


Califf, Robert M., Celeste Wong, P Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega, and Jessica L. Baseline Study Group. “Biological and clinical correlates of the patient health questionnaire-9: exploratory cross-sectional analyses of the baseline health study.” Bmj Open 12, no. 1 (January 4, 2022): e054741.

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Dragani, Tommaso A., Francesca Colombo, Elizabeth N. Pavlisko, and Victor L. Roggli. “Response to comments on 'Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure' by Farioli et al. and Oddone et al.” Carcinogenesis 40, no. 3 (May 14, 2019): 490–91.

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Warraich, Haider J., and Robert M. Califf. “Differences in Health Outcomes between Men and Women: Biological, Behavioral, and Societal Factors.” Clin Chem 65, no. 1 (January 2019): 19–23.

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Califf, Robert M., and Frank E. Harrell. “Individual risk prediction using data beyond the medical clinic.” Cmaj 190, no. 32 (August 13, 2018): E947–48.

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