Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

ter Maaten, JM, Dunning, AM, Valente, MAE, Damman, K, Ezekowitz, JA, Califf, RM, Starling, RC, van der Meer, P, O'Connor, CM, Schulte, PJ, Testani, JM, Hernandez, AF, Tang, WHW, and Voors, AA. "Diuretic response in acute heart failure-an analysis from ASCEND-HF." American Heart Journal 170, no. 2 (August 2015): 313-321.

PMID
26299229
Full Text

Cannon, CP, Blazing, MA, Giugliano, RP, McCagg, A, White, JA, Theroux, P, Darius, H, Lewis, BS, Ophuis, TO, Jukema, JW, De Ferrari, GM, Ruzyllo, W, De Lucca, P, Im, K, Bohula, EA, Reist, C, Wiviott, SD, Tershakovec, AM, Musliner, TA, Braunwald, E, Califf, RM, and IMPROVE-IT Investigators, . "Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes." The New England Journal of Medicine 372, no. 25 (June 3, 2015): 2387-2397.

PMID
26039521
Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American Heart Journal 169, no. 6 (June 1, 2015): 743-750. (Review)

Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond - Addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American Heart Journal 169, no. 6 (June 1, 2015): 743-750.

Full Text

Washam, JB, Stevens, SR, Lokhnygina, Y, Halperin, JL, Breithardt, G, Singer, DE, Mahaffey, KW, Hankey, GJ, Berkowitz, SD, Nessel, CC, Fox, KAA, Califf, RM, Piccini, JP, Patel, MR, and ROCKET AF Steering Committee and Investigators, . "Digoxin use in patients with atrial fibrillation and adverse cardiovascular outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)." Lancet (London, England) 385, no. 9985 (June 2015): 2363-2370.

PMID
25749644
Full Text

Anderson, ML, Califf, RM, Sugarman, J, and participants in the NIH Health Care Systems Research Collaboratory Cluster Randomized Trial Workshop, . "Ethical and regulatory issues of pragmatic cluster randomized trials in contemporary health systems." Clinical Trials (London, England) 12, no. 3 (June 2015): 276-286.

PMID
25733677
Full Text

Roe, MT, Mahaffey, KW, Ezekowitz, JA, Alexander, JH, Goodman, SG, Hernandez, A, Temple, T, Berdan, L, Califf, RM, Harrington, RA, Peterson, ED, and Armstrong, PW. "The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations." American Heart Journal 169, no. 6 (June 2015): 743-750. (Review)

PMID
26027610
Full Text

Eapen, ZJ, McCoy, LA, Fonarow, GC, Yancy, CW, Miranda, ML, Peterson, ED, Califf, RM, and Hernandez, AF. "Utility of socioeconomic status in predicting 30-day outcomes after heart failure hospitalization." Circulation. Heart Failure 8, no. 3 (May 2015): 473-480.

PMID
25747700
Full Text

Bethel, MA, Green, JB, Milton, J, Tajar, A, Engel, SS, Califf, RM, Holman, RR, and TECOS Executive Committee, . "Regional, age and sex differences in baseline characteristics of patients enrolled in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS)." Diabetes, Obesity & Metabolism 17, no. 4 (April 2015): 395-402.

PMID
25600421
Full Text

Mark, DB, Hodgson, P, Anuels, J, and Califf, RM. "Transitions at the american heart journal." American Heart Journal 169, no. 4 (April 2015): 445-null.

PMID
25819848
Full Text

Pages