Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

Kong, D. F., K. L. Lee, F. E. Harrell, J. M. Boswick, D. B. Mark, M. A. Hlatky, R. M. Califf, and D. B. Pryor. “Clinical experience and predicting survival in coronary disease..” Archives of Internal Medicine 149, no. 5 (May 1989): 1177–81. https://doi.org/10.1001/archinte.1989.00390050133027.

PMID
2719510
Full Text

Califf, R. M., F. E. Harrell, K. L. Lee, J. S. Rankin, M. A. Hlatky, D. B. Mark, R. H. Jones, L. H. Muhlbaier, H. N. Oldham, and D. B. Pryor. “The evolution of medical and surgical therapy for coronary artery disease. A 15-year perspective..” Jama 261, no. 14 (April 14, 1989): 2077–86.

PMID
2784512
Scholars@Duke

Califf, R. M. “Myocardial reperfusion: is it ever too late?.” Journal of the American College of Cardiology 13, no. 5 (April 1989): 1130–32. https://doi.org/10.1016/0735-1097(89)90274-x.

PMID
2522469
Full Text

Rankin, J. S., M. S. Hickey, L. R. Smith, N. P. Debruijn, F. M. Clements, L. H. Muhlbaier, J. E. Lowe, A. S. Wechsler, R. M. Califf, and J. G. Reves. “Current management of mitral valve incompetence associated with coronary artery disease..” Journal of Cardiac Surgery 4, no. 1 (March 1989): 25–42. https://doi.org/10.1111/j.1540-8191.1989.tb00254.x.

PMID
2519980
Full Text

Wall, T. C., D. B. Mark, R. M. Califf, G. Collins, R. Burgess, T. N. Skelton, T. Hinohara, D. F. Kong, S. Mantell, and L. Aronson. “Prediction of early recurrent myocardial ischemia and coronary reocclusion after successful thrombolysis: a qualitative and quantitative angiographic study..” Am J Cardiol 63, no. 7 (February 15, 1989): 423–28.

PMID
2492742
Scholars@Duke

Quigley, P. J., M. A. Hlatky, T. Hinohara, D. S. Rendall, J. A. Perez, H. R. Phillips, R. M. Califf, and R. S. Stack. “Repeat percutaneous transluminal coronary angioplasty and predictors of recurrent restenosis..” The American Journal of Cardiology 63, no. 7 (February 1989): 409–13. https://doi.org/10.1016/0002-9149(89)90309-3.

PMID
2521766
Full Text

Topol, E. J., B. S. George, D. J. Kereiakes, D. C. Stump, R. J. Candela, C. W. Abbottsmith, L. Aronson, A. Pickel, J. M. Boswick, and K. L. Lee. “A randomized controlled trial of intravenous tissue plasminogen activator and early intravenous heparin in acute myocardial infarction..” Circulation 79, no. 2 (February 1989): 281–86. https://doi.org/10.1161/01.cir.79.2.281.

PMID
2492454
Full Text

Antman, E. M., W. D. Dupont, J. Bonalsky, R. M. Califf, S. Corwin, L. Fink, D. E. Hansen, et al. “Early treatment with intravenous metoprolol for suspected acute myocardial infarction: a Phase IV United States trial.” International Journal of Cardiology 23, no. 2 (January 1, 1989): 185–97. https://doi.org/10.1016/0167-5273(89)90247-7.

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Harrelson, L., R. M. Califf, and K. Lee. “Use of ejection fraction as a surrogate endpoint for death in clinical trials of acute myocardial infraction.” Controlled Clinical Trials 10, no. 3 (January 1, 1989). https://doi.org/10.1016/0197-2456(89)90173-6.

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Topol, E. J., S. G. Ellis, R. M. Califf, B. S. George, D. C. Stump, E. R. Bates, E. G. Nabel, et al. “Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction.” Journal of the American College of Cardiology 14, no. 4 (January 1, 1989): 877–84. https://doi.org/10.1016/0735-1097(89)90458-0.

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