Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

Califf, R. M., F. E. Harrell, K. L. Lee, J. S. Rankin, D. B. Mark, M. A. Hlatky, L. H. Muhlbaier, A. S. Wechsler, R. H. Jones, and H. N. Oldham. “Changing efficacy of coronary revascularization. Implications for patient selection..” Circulation 78, no. 3 Pt 2 (September 1988): I185–91.

PMID
3261657
Scholars@Duke

Califf, R. M., E. J. Topol, B. S. George, J. M. Boswick, C. Abbottsmith, K. N. Sigmon, R. Candela, R. Masek, D. Kereiakes, and W. W. O’Neill. “Hemorrhagic complications associated with the use of intravenous tissue plasminogen activator in treatment of acute myocardial infarction..” The American Journal of Medicine 85, no. 3 (September 1988): 353–59. https://doi.org/10.1016/0002-9343(88)90586-4.

PMID
3137818
Full Text

Stack, R. S., R. M. Califf, T. Hinohara, H. R. Phillips, D. B. Pryor, C. A. Simonton, E. B. Carlson, K. G. Morris, V. S. Behar, and Y. Kong. “Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction..” J Am Coll Cardiol 11, no. 6 (June 1988): 1141–49.

PMID
2966834
Scholars@Duke

Topol, E. J., R. M. Califf, B. S. George, D. J. Kereiakes, D. Rothbaum, R. J. Candela, C. W. Abbotsmith, C. A. Pinkerton, D. C. Stump, and D. Collen. “Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen activator and urokinase in patients with acute myocardial infarction..” Circulation 77, no. 5 (May 1988): 1100–1107. https://doi.org/10.1161/01.cir.77.5.1100.

PMID
2966017
Full Text

Califf, R. M., E. J. Topol, B. S. George, J. M. Boswick, K. L. Lee, D. Stump, J. Dillon, C. Abbottsmith, R. J. Candela, and D. J. Kereiakes. “Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen activator fails: results of the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) I trial..” Circulation 77, no. 5 (May 1988): 1090–99. https://doi.org/10.1161/01.cir.77.5.1090.

PMID
2966016
Full Text

Kereiakes, D. J., E. J. Topol, B. S. George, C. W. Abbottsmith, R. S. Stack, R. J. Candela, W. W. O’Neill, L. H. Martin, and R. M. Califf. “Emergency coronary artery bypass surgery preserves global and regional left ventricular function after intravenous tissue plasminogen activator therapy for acute myocardial infarction..” Journal of the American College of Cardiology 11, no. 5 (May 1988): 899–907. https://doi.org/10.1016/s0735-1097(98)90043-2.

PMID
2965716
Full Text

Worley, S. J., D. B. Mark, W. M. Smith, P. Wolf, R. M. Califf, H. C. Strauss, M. G. Manwaring, and R. E. Ideker. “Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis..” Journal of the American College of Cardiology 11, no. 5 (May 1988): 1041–51. https://doi.org/10.1016/s0735-1097(98)90064-x.

PMID
3281991
Full Text

Califf, R. M., W. O’Neil, R. S. Stack, L. Aronson, D. B. Mark, S. Mantell, B. S. George, R. J. Candela, D. J. Kereiakes, and C. Abbottsmith. “Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis..” Annals of Internal Medicine 108, no. 5 (May 1988): 658–62. https://doi.org/10.7326/0003-4819-108-5-658.

PMID
3128953
Full Text

Topol, E. J., B. S. George, D. J. Kereiakes, R. J. Candela, C. W. Abbottsmith, D. C. Stump, J. M. Boswick, R. S. Stack, and R. M. Califf. “Comparison of two dose regimens of intravenous tissue plasminogen activator for acute myocardial infarction..” The American Journal of Cardiology 61, no. 10 (April 1988): 723–28. https://doi.org/10.1016/0002-9149(88)91055-7.

PMID
2965504
Full Text

Simonton, C. A., D. B. Mark, T. Hinohara, D. S. Rendall, H. R. Phillips, R. H. Peter, V. S. Behar, Y. Kong, W. G. O’Callaghan, and C. O’Connor. “Late restenosis after emergent coronary angioplasty for acute myocardial infarction: comparison with elective coronary angioplasty..” J Am Coll Cardiol 11, no. 4 (April 1988): 698–705.

PMID
2965171
Scholars@Duke

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