Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

Califf, RM. "LCZ696: too good to be true?." European Heart Journal 36, no. 7 (February 2015): 410-412.

PMID
25549727
Full Text

Putera, M, Roark, R, Lopes, RD, Udayakumar, K, Peterson, ED, Califf, RM, and Shah, BR. "Translation of acute coronary syndrome therapies: from evidence to routine clinical practice." American Heart Journal 169, no. 2 (February 2015): 266-273.

PMID
25641536
Full Text

Tang, WHW, Dupont, M, Hernandez, AF, Voors, AA, Hsu, AP, Felker, GM, Butler, J, Metra, M, Anker, SD, Troughton, RW, Gottlieb, SS, McMurray, JJ, Armstrong, PW, Massie, BM, Califf, RM, O'Connor, CM, and Starling, RC. "Comparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: results from the ASCEND-HF trial." Jacc. Heart Failure 3, no. 1 (January 2015): 40-49.

PMID
25453534
Full Text

Koshizaka, M, Lopes, RD, Reyes, EM, Gibson, CM, Schulte, PJ, Hafley, GE, Hernandez, AF, Green, JB, Kouchoukos, NT, Califf, RM, Ferguson, TB, Peterson, ED, and Alexander, JH. "Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery: results from the Project of Ex-vivo Vein Graft Engineering via Transfection IV trial." American Heart Journal 169, no. 1 (January 2015): 175-184.

PMID
25497264
Full Text

Van Wagoner, DR, Piccini, JP, Albert, CM, Anderson, ME, Benjamin, EJ, Brundel, B, Califf, RM, Calkins, H, Chen, P-S, Chiamvimonvat, N, Darbar, D, Eckhardt, LL, Ellinor, PT, Exner, DV, Fogel, RI, Gillis, AM, Healey, J, Hohnloser, SH, Kamel, H, Lathrop, DA, Lip, GYH, Mehra, R, Narayan, SM, Olgin, J, Packer, D, Peters, NS, Roden, DM, Ross, HM, Sheldon, R, and Wehrens, XHT. "Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013." Heart Rhythm 12, no. 1 (January 2015): e5-e29.

PMID
25460864
Full Text

Preiss, D, Haffner, SM, Thomas, LE, Sun, J-L, Sattar, N, Yates, T, J Davies, M, McMurray, JJ, Holman, RR, Califf, RM, and Kraus, WE. "Change in levels of physical activity after diagnosis of type 2 diabetes: an observational analysis from the NAVIGATOR study." Diabetes, Obesity & Metabolism 16, no. 12 (December 2014): 1265-1268.

PMID
24861892
Full Text

Breithardt, G, Baumgartner, H, Berkowitz, SD, Hellkamp, AS, Piccini, JP, Stevens, SR, Lokhnygina, Y, Patel, MR, Halperin, JL, Singer, DE, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee & Investigators, . "Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial." European Heart Journal 35, no. 47 (December 2014): 3377-3385.

PMID
25148838
Full Text

Califf, RM. "Commentary on Vickers." Clinical Trials (London, England) 11, no. 6 (December 2014): 626-627.

PMID
25389227
Full Text

van Diepen, S, Podder, M, Hernandez, AF, Westerhout, CM, Armstong, PW, McMurray, JJV, Eapen, ZJ, Califf, RM, Starling, RC, O'Connor, CM, and Ezekowitz, JA. "Acute decompensated heart failure patients admitted to critical care units: insights from ASCEND-HF." International Journal of Cardiology 177, no. 3 (December 2014): 840-846.

PMID
25465830
Full Text

Patel, PA, Heizer, G, O'Connor, CM, Schulte, PJ, Dickstein, K, Ezekowitz, JA, Armstrong, PW, Hasselblad, V, Mills, RM, McMurray, JJV, Starling, RC, Tang, WHW, Califf, RM, and Hernandez, AF. "Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF." Circulation. Heart Failure 7, no. 6 (November 2014): 918-925.

PMID
25281655
Full Text

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