Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7028, Durham, NC 27705
Phone (919) 668-8820
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

Breithardt, G, Baumgartner, H, Berkowitz, SD, Hellkamp, AS, Piccini, JP, Stevens, SR, Lokhnygina, Y, Patel, MR, Halperin, JL, Singer, DE, Hankey, GJ, Hacke, W, Becker, RC, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and ROCKET AF Steering Committee & Investigators, . "Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial." European heart journal 35, no. 47 (December 2014): 3377-3385.

PMID
25148838
Full Text

Califf, RM. "Commentary on Vickers." Clinical trials (London, England) 11, no. 6 (December 2014): 626-627.

PMID
25389227
Full Text

van Diepen, S, Podder, M, Hernandez, AF, Westerhout, CM, Armstong, PW, McMurray, JJV, Eapen, ZJ, Califf, RM, Starling, RC, O'Connor, CM, and Ezekowitz, JA. "Acute decompensated heart failure patients admitted to critical care units: insights from ASCEND-HF." International journal of cardiology 177, no. 3 (December 2014): 840-846.

PMID
25465830
Full Text

Patel, PA, Heizer, G, O'Connor, CM, Schulte, PJ, Dickstein, K, Ezekowitz, JA, Armstrong, PW, Hasselblad, V, Mills, RM, McMurray, JJV, Starling, RC, Tang, WHW, Califf, RM, and Hernandez, AF. "Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF." Circulation. Heart failure 7, no. 6 (November 2014): 918-925.

PMID
25281655
Full Text

Thomas, KL, Shah, BR, Elliot-Bynum, S, Thomas, KD, Damon, K, Allen LaPointe, NM, Calhoun, S, Thomas, L, Breathett, K, Mathews, R, Anderson, M, Califf, RM, and Peterson, ED. "Check it, change it: a community-based, multifaceted intervention to improve blood pressure control." Circulation. Cardiovascular quality and outcomes 7, no. 6 (November 2014): 828-834.

PMID
25351480
Full Text

Park, D-W, Clare, RM, Schulte, PJ, Pieper, KS, Shaw, LK, Califf, RM, Ohman, EM, Van de Werf, F, Hirji, S, Harrington, RA, Armstrong, PW, Granger, CB, Jeong, M-H, and Patel, MR. "Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction." JAMA 312, no. 19 (November 2014): 2019-2027.

PMID
25399277
Full Text

Subherwal, S, Patel, MR, Chiswell, K, Tidemann-Miller, BA, Jones, WS, Conte, MS, White, CJ, Bhatt, DL, Laird, JR, Hiatt, WR, Tasneem, A, and Califf, RM. "Clinical trials in peripheral vascular disease: pipeline and trial designs: an evaluation of the ClinicalTrials.gov database." November 2014.

PMID
25239436
Full Text

de Barros e Silva, PGM, Califf, RM, Sun, J-L, McMurray, JJV, Holman, R, Haffner, S, Thomas, L, and Lopes, RD. "Chronic obstructive pulmonary disease and cardiovascular risk: insights from the NAVIGATOR trial." International journal of cardiology 176, no. 3 (October 2014): 1126-1128. (Letter)

PMID
25220176
Full Text

Hess, CN, Lopes, RD, Gibson, CM, Hager, R, Wojdyla, DM, Englum, BR, Mack, MJ, Califf, RM, Kouchoukos, NT, Peterson, ED, and Alexander, JH. "Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV." Circulation 130, no. 17 (October 2014): 1445-1451.

PMID
25261549
Full Text

Califf, RM. "Patient-centered outcomes composites: a glimpse of the future." Circulation 130, no. 15 (October 2014): 1223-1224.

PMID
25200211
Full Text

Pages