Robert M. Califf

Adjunct Professor of Medicine
Donald F. Fortin, M.D. Distinguished Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 100 Trent Drive, Suite401, Davison Building, Durham, NC 27710
Phone (919) 668-9222
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Publications

Diepen, Sean van, Mohua Podder, Adrian F. Hernandez, Cynthia M. Westerhout, Paul W. Armstong, John J. V. McMurray, Zubin J. Eapen, et al. “Acute decompensated heart failure patients admitted to critical care units: insights from ASCEND-HF.” International Journal of Cardiology 177, no. 3 (December 2014): 840–46. https://doi.org/10.1016/j.ijcard.2014.11.007.

PMID
25465830
Full Text

Preiss, D., S. M. Haffner, L. E. Thomas, J. -. L. Sun, N. Sattar, T. Yates, M. J Davies, et al. “Change in levels of physical activity after diagnosis of type 2 diabetes: an observational analysis from the NAVIGATOR study.” Diabetes Obes Metab 16, no. 12 (December 2014): 1265–68. https://doi.org/10.1111/dom.12320.

PMID
24861892
Full Text

Park, Duk-Woo, Robert M. Clare, Phillip J. Schulte, Karen S. Pieper, Linda K. Shaw, Robert M. Califf, E Magnus Ohman, et al. “Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction.” Jama 312, no. 19 (November 19, 2014): 2019–27. https://doi.org/10.1001/jama.2014.15095.

PMID
25399277
Full Text

Subherwal, Sumeet, Manesh R. Patel, Karen Chiswell, Beth A. Tidemann-Miller, W Schuyler Jones, Michael S. Conte, Christopher J. White, et al. “Clinical trials in peripheral vascular disease: pipeline and trial designs: an evaluation of the ClinicalTrials.gov database.” In Circulation, 130:1812–19, 2014. https://doi.org/10.1161/CIRCULATIONAHA.114.011021.

PMID
25239436
Full Text

Patel, Priyesh A., Gretchen Heizer, Christopher M. O’Connor, Phillip J. Schulte, Kenneth Dickstein, Justin A. Ezekowitz, Paul W. Armstrong, et al. “Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF.” Circ Heart Fail 7, no. 6 (November 2014): 918–25. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000872.

PMID
25281655
Full Text

Thomas, Kevin L., Bimal R. Shah, Sharon Elliot-Bynum, Kristin D. Thomas, Katrina Damon, Nancy M. Allen LaPointe, Sarah Calhoun, et al. “Check it, change it: a community-based, multifaceted intervention to improve blood pressure control.” Circulation. Cardiovascular Quality and Outcomes 7, no. 6 (November 2014): 828–34. https://doi.org/10.1161/circoutcomes.114.001039.

PMID
25351480
Full Text

Hess, Connie N., Renato D. Lopes, C Michael Gibson, Rebecca Hager, Daniel M. Wojdyla, Brian R. Englum, Michael J. Mack, et al. “Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV.” Circulation 130, no. 17 (October 21, 2014): 1445–51. https://doi.org/10.1161/CIRCULATIONAHA.113.008193.

PMID
25261549
Full Text

Barros e Silva, Pedro G. M. de, Robert M. Califf, Jie-Lena Sun, John J. V. McMurray, Rury Holman, Steven Haffner, Laine Thomas, and Renato D. Lopes. “Chronic obstructive pulmonary disease and cardiovascular risk: insights from the NAVIGATOR trial.” Int J Cardiol 176, no. 3 (October 20, 2014): 1126–28. https://doi.org/10.1016/j.ijcard.2014.07.297.

PMID
25220176
Full Text

Holman, Rury R., Harald Sourij, and Robert M. Califf. “Cardiovascular outcome trials of glucose-lowering strategies in type 2 diabetes--Authors' reply.” Lancet 384, no. 9948 (September 20, 2014): 1097–98. https://doi.org/10.1016/S0140-6736(14)61674-3.

PMID
25241719
Full Text

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