Robert M. Califf

Professor of Medicine
Donald F. Fortin, M.D. Professor of Cardiology, in the School of Medicine
Member of the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7028, Durham, NC 27705
Phone (919) 668-8820
Email address robert.califf@duke.edu

Robert Califf, MD MACC, is the Donald F. Fortin, MD, Professor of Cardiology. He is also Professor of Medicine in the Division of Cardiology and remains a practicing cardiologist. Dr. Califf was the Commissioner of Food and Drugs in 2016-2017 and  Deputy Commissioner for Medical Products and Tobacco from February 2015 until his appointment as Commissioner in February 2016. Prior to joining the FDA, Dr. Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine, health outcomes research, healthcare quality, and clinical research, Dr. Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science, with more than 1,200 publications in the peer-reviewed literature.

Dr. Califf is a Member of the National Academy of Medicine (formerly known as the Institute of Medicine (IOM)) in 2016, one of the highest honors in the fields of health and medicine. Dr. Califf has served on numerous IOM committees, and he has served as a member of the FDA Cardiorenal Advisory Panel and FDA Science Board's Subcommittee on Science and Technology. Dr. Califf has also served on the Board of Scientific Counselors for the National Library of Medicine, as well as on advisory committees for the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences and the Council of the National Institute on Aging.

He has led major initiatives aimed at improving methods and infrastructure for clinical research, including the Clinical Trials Transformation Initiative (CTTI), a public-private partnership co-founded by the FDA and Duke. He also served as the principal investigator for Duke's Clinical and Translational Science Award and the NIH Health Care Systems Research Collaboratory coordinating center and co-PI of the Patient Centered Outcomes Research Institute Network.

Associated Faculty Labs

Publications

De Ferrari, GM, Fox, KAA, White, JA, Giugliano, RP, Tricoci, P, Reynolds, HR, Hochman, JS, Gibson, CM, Théroux, P, Harrington, RA, Van de Werf, F, White, HD, Califf, RM, and Newby, LK. "Outcomes among non-ST-segment elevation acute coronary syndromes patients with no angiographically obstructive coronary artery disease: observations from 37,101 patients." European heart journal. Acute cardiovascular care 3, no. 1 (March 2014): 37-45.

PMID
24562802
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Califf, RM. "Integrated efficacy to effectiveness trials." Clinical pharmacology and therapeutics 95, no. 2 (February 2014): 131-133.

PMID
24448458
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Inrig, JK, Califf, RM, Tasneem, A, Vegunta, RK, Molina, C, Stanifer, JW, Chiswell, K, and Patel, UD. "The landscape of clinical trials in nephrology: A systematic review of clinicaltrials.gov." American Journal of Kidney Diseases 63, no. 5 (January 1, 2014): 771-780.

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Steinberg, BA, Hellkamp, AS, Lokhnygina, Y, Halperin, JL, Breithardt, G, Passman, R, Hankey, GJ, Patel, MR, Becker, RC, Singer, DE, Hacke, W, Berkowitz, SD, Nessel, CC, Mahaffey, KW, Fox, KAA, Califf, RM, and Piccini, JP. "Use and outcomes of antiarrhythmic therapy in patients with atrial fibrillation receiving oral anticoagulation: Results from the ROCKET AF trial." Heart Rhythm 11, no. 6 (January 1, 2014): 925-932.

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Vemulapalli, S, Ard, J, Bakris, GL, Bhatt, DL, Brown, AS, Cushman, WC, Ferdinand, KC, Flack, JM, Fleg, JL, Katzen, BT, Kostis, JB, Oparil, S, Patel, CB, Pepine, CJ, Piña, IL, Rocha-Singh, KJ, Townsend, RR, Peterson, ED, Califf, RM, and Patel, MR. "Proceedings from Duke resistant hypertension think tank." American Heart Journal 167, no. 6 (January 1, 2014).

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Hill, KD, Chiswell, K, Califf, RM, Pearson, G, and Li, JS. "Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov." American Heart Journal 167, no. 6 (January 1, 2014).

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Fleurence, RL, Curtis, LH, Califf, RM, Platt, R, Selby, JV, and Brown, JS. "Launching PCORnet, a national patient-centered clinical research network." Journal of the American Medical Informatics Association 21, no. 4 (January 1, 2014): 578-582.

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Hess, CN, Roe, MT, Gibson, CM, J Temple, R, Pencina, MJ, Zarin, DA, Anstrom, KJ, Alexander, JH, Sherman, RE, Fiedorek, FT, Mahaffey, KW, Lee, KL, Chow, SC, Armstrong, PW, and Califf, RM. "Independent data monitoring committees: Preparing a path for the future." American Heart Journal 168, no. 2 (January 1, 2014).

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Califf, RM. "The new era of clinical research: Using data for multiple purposes." American Heart Journal 168, no. 2 (January 1, 2014): 133-134.

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Bernardez-Pereira, S, Lopes, RD, Carrion, MJM, Santucci, EV, Soares, RM, De Oliveira Abreu, M, Laranjeira, LN, Ikeoka, DT, Zazula, AD, Moreira, FR, Cavalcanti, AB, Mesquita, ET, Peterson, ED, Califf, RM, and Berwanger, O. "Prevalence, characteristics, and predictors of early termination of cardiovascular clinical trials due to low recruitment: Insights from the ClinicalTrials.gov registry." American Heart Journal 168, no. 2 (January 1, 2014).

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