Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Prpic, V., J. G. Fitz, Y. Wang, J. R. Raymond, M. N. Garnovskaya, and R. A. Liddle. “Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells..” Am J Physiol 275, no. 4 (October 1998): G689–95. https://doi.org/10.1152/ajpgi.1998.275.4.G689.

PMID
9756498
Full Text

Prpic, V., J. G. Fitz, Y. Wang, J. R. Raymond, M. N. Garnovskaya, and R. A. Liddle. “Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.” American Journal of Physiology Gastrointestinal and Liver Physiology 275, no. 4 (October 1, 1998): G689–95.

Scholars@Duke

Spannagel, A. W., G. M. Green, D. Guan, R. A. Liddle, K. Faull, and J. Reeve. “Erratum: Purification and characterization of a luminal cholecystokinin- releasing factor from rat intestinal secretion (Proceedings of the National Academy of Sciences of the United States of America (April 30, 1996) 93:9 (4415-4420)).” Proceedings of the National Academy of Sciences of the United States of America 95, no. 16 (August 4, 1998).

Scholars@Duke

Raybould, H. E., J. H. Meyer, Y. Tabrizi, R. A. Liddle, and P. Tso. “Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation.” American Journal of Physiology  Regulatory Integrative and Comparative Physiology 274, no. 6 43-6 (July 14, 1998).

Scholars@Duke

Raybould, Helen E., James H. Meyer, Yuri Tabrizi, Rodger A. Liddle, and Patrick Tso. “Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation..” Am J Physiol Regul Integr Comp Physiol 274, no. 6 (June 1, 1998): R1834–38. https://doi.org/10.1152/ajpregu.1998.274.6.R1834.

PMID
29586675
Full Text

Liddle, R. A. “On the measurement of cholecystokinin..” Clin Chem 44, no. 5 (May 1998): 903–4.

PMID
9590358
Scholars@Duke

Wang, Y., V. Prpic, J. G. Fitz, and R. A. Liddle. “Regulation of cholecystokinin secretion in STC-1 cells through pH-sensitive potassium channels..” Gastroenterology 114, no. 4 (April 15, 1998): A1189–A1189.

Scholars@Duke

McVey, D. C., J. Romac, W. Clay, T. Kost, R. A. Liddle, and S. R. Vigna. “Monitor peptide binding sites are expressed in liver and small intestine.” Gastroenterology 114 (April 1998): A1164–A1164. https://doi.org/10.1016/s0016-5085(98)84732-x.

Full Text

Kemp, J., J. Wolfe, J. Grady, C. LaForce, E. Stahl, T. Arledge, and R. Liddle. “Salmeterol powder compared with albuterol aerosol as maintenance therapy for asthma in adolescent and adult patients..” Clin Ther 20, no. 2 (March 1998): 270–82. https://doi.org/10.1016/s0149-2918(98)80090-8.

PMID
9589818
Full Text

Spannagel, A. W., J. R. Reeve, G. H. Greeley, N. Yanaihara, R. A. Liddle, and G. M. Green. “Bioactivity of intraduodenally and intravenously infused fragments of luminal cholecystokinin releasing factor (LCRF)..” Regul Pept 73, no. 3 (February 27, 1998): 161–64. https://doi.org/10.1016/s0167-0115(97)01074-4.

PMID
9556078
Full Text

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