Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Reeve, J. R., V. E. Eysselein, G. Rosenquist, J. Zeeh, U. Regner, F. J. Ho, P. Chew, et al. “Evidence that CCK-58 has structure that influences its biological activity.” American Journal of Physiology  Gastrointestinal and Liver Physiology 270, no. 5 33-5 (December 1, 1996).

Scholars@Duke

Mangel, A. W., L. Scott, V. Prpic, and R. A. Liddle. “Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.” American Journal of Physiology  Gastrointestinal and Liver Physiology 271, no. 4 34-4 (October 1, 1996).

Scholars@Duke

Mangel, A. W., L. Scott, V. Prpic, and R. A. Liddle. “Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.” American Journal of Physiology Gastrointestinal and Liver Physiology 271, no. 4 (October 1, 1996): G650–54.

Scholars@Duke

Whitcomb, D. C., M. C. Gorry, R. A. Preston, W. Furey, M. J. Sossenheimer, C. D. Ulrich, S. P. Martin, et al. “Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene..” Nat Genet 14, no. 2 (October 1996): 141–45. https://doi.org/10.1038/ng1096-141.

PMID
8841182
Full Text

Reeve, J. R., V. E. Eysselein, G. Rosenquist, J. Zeeh, U. Regner, F. J. Ho, P. Chew, et al. “Evidence that CCK-58 has structure that influences its biological activity.” American Journal of Physiology Gastrointestinal and Liver Physiology 270, no. 5 (May 1, 1996): G860–68.

Scholars@Duke

Reeve, J. R., V. E. Eysselein, G. Rosenquist, J. Zeeh, U. Regner, F. J. Ho, P. Chew, et al. “Evidence that CCK-58 has structure that influences its biological activity..” Am J Physiol 270, no. 5 Pt 1 (May 1996): G860–68. https://doi.org/10.1152/ajpgi.1996.270.5.G860.

PMID
8967499
Full Text

Spannagel, A. W., G. M. Green, D. Guan, R. A. Liddle, K. Faull, and J. R. Reeve. “Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion..” Proc Natl Acad Sci U S A 93, no. 9 (April 30, 1996): 4415–20. https://doi.org/10.1073/pnas.93.9.4415.

PMID
8633081
Full Text

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