Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Chandra, R, Wang, Y, Shahid, RA, Vigna, SR, Freedman, NJ, and Liddle, RA. "Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion." J Clin Invest 123, no. 8 (August 2013): 3343-3352.

PMID
23863714
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Sundaresan, S, Shahid, R, Riehl, TE, Chandra, R, Nassir, F, Stenson, WF, Liddle, RA, and Abumrad, NA. "CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin." FASEB JOURNAL 27, no. 3 (March 2013): 1191-1202.

PMID
23233532
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Chandra, R, and Liddle, RA. "Modulation of pancreatic exocrine and endocrine secretion." Current Opinion in Gastroenterology 29, no. 5 (2013): 517-522.

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Shah, TU, Liddle, R, Branch, MS, Jowell, P, Obando, J, and Poleski, M. "Pilot study of aprepitant for prevention of post-ERCP pancreatitis in high risk patients: a phase II randomized, double-blind placebo controlled trial. (Published online)" JOP 13, no. 5 (September 10, 2012): 514-518.

PMID
22964958
Scholars@Duke

Chandra, R, and Liddle, RA. "Neurohormonal regulation of pancreatic secretion." Curr Opin Gastroenterol 28, no. 5 (September 2012): 483-487. (Review)

PMID
22782019
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Romac, JM-J, Shahid, RA, Choi, SS, Karaca, GF, Westphalen, CB, Wang, TC, and Liddle, RA. "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1β in the pancreas." Am J Physiol Gastrointest Liver Physiol 302, no. 5 (March 1, 2012): G535-G541.

PMID
22173919
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Liddle, RA. "2012 American pancreatic association presidential address: Fostering translation." Pancreas 41, no. 8 (2012): 1165-1166.

PMID
23086240
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Balmadrid, BL, Thomas, CM, Coffman, CJ, Liddle, RA, and Fisher, DA. "Factors associated with survival of veterans with gastrointestinal neuroendocrine tumors." J Cancer Epidemiol 2012 (2012): 986708-.

PMID
22693504
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Forsmark, CE, and Liddle, RA. "The challenging task of treating painful chronic pancreatitis." Gastroenterology 143, no. 3 (2012): 533-535.

PMID
22841737
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Liddle, RA. "Regulation of Pancreatic Secretion." Physiology of the Gastrointestinal Tract 2 (2012): 1425-1460.

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