Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Bohorquez, Diego V., Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang, and Rodger A. Liddle. “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.” Journal of Clinical Investigation 125, no. 2 (February 2015): 782–86. https://doi.org/10.1172/JCI78361.

Full Text

Diamond, P., R. Liddle, and D. Richards. “Labouring in the shadow of the british political tradition: The Dilemma of 'One Nation' politics in an age of disunification.” Political Quarterly 86, no. 1 (January 1, 2015): 52–61. https://doi.org/10.1111/1467-923X.12144.

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Shahid, Rafiq A., Steven R. Vigna, Amanda C. Layne, Joelle M-J Romac, and Rodger A. Liddle. “Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice..” Cell Mol Gastroenterol Hepatol 1, no. 1 (January 2015): 75–86. https://doi.org/10.1016/j.jcmgh.2014.11.002.

PMID
25729765
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Freeman, M., S. J. Pandol, R. A. Liddle, A. K. Saluja, C. Fernandez-Del Castillo, A. Maitra, M. Sahin-Toth, and V. L. W. Go. “Minutes of the business meeting of the American Pancreatic Association, Friday, November 1, 2013, Miami, Florida.” Pancreas 43, no. 8 (November 10, 2014): 1141–42. https://doi.org/10.1097/MPA.0000000000000227.

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Shahid, Rafiq A., Supriya J. Davis, Steven R. Vigna, and Rodger A. Liddle. “Bile Acid-Induced Acute Pancreatitis in Mice Is Caused by Acinar Cell Leukotriene B-4 Secretion Through a Calcium-Independent Pathway.” In Gastroenterology, 146:S297–S297. W B SAUNDERS CO-ELSEVIER INC, 2014.

Scholars@Duke

Vigna, Steven R., Rafiq A. Shahid, and Rodger A. Liddle. “Ethanol contributes to neurogenic pancreatitis by activation of TRPV1..” Faseb J 28, no. 2 (February 2014): 891–96. https://doi.org/10.1096/fj.13-236208.

PMID
24221085
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Bohórquez, Diego V., Leigh A. Samsa, Andrew Roholt, Satish Medicetty, Rashmi Chandra, and Rodger A. Liddle. “An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy..” Plos One 9, no. 2 (2014). https://doi.org/10.1371/journal.pone.0089881.

PMID
24587096
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La Sala, Michael S., Maria D. Hurtado, Alicia R. Brown, Diego V. Bohórquez, Rodger A. Liddle, Herbert Herzog, Sergei Zolotukhin, and Cedrick D. Dotson. “Modulation of taste responsiveness by the satiation hormone peptide YY..” Faseb J 27, no. 12 (December 2013): 5022–33. https://doi.org/10.1096/fj.13-228064.

PMID
24043261
Full Text

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