Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Nicholson, WE, Liddle, RA, Puett, D, and Liddle, GW. "Adrenocorticotropic hormone biotransformation, clearance, and catabolism." Endocrinology 103, no. 4 (October 1978): 1344-1351.

PMID
217674
Full Text

Robinson, JP, Derreberry, S, Liddle, RA, Ascoli, M, and Puett, D. "Renal uptake of lutropin. Studies based on electron microscopic autoradiography and nephrectomy." Mol Cell Biochem 15, no. 1 (March 21, 1977): 63-66.

PMID
865484
Scholars@Duke

Ascoli, M, Liddle, RA, and Puett, D. "Renal and hepatic lysosomal catabolism of luteinizing hormone." Mol Cell Endocrinol 4, no. 5 (May 1976): 297-310.

PMID
950069
Scholars@Duke

Ascoli, M, Liddle, RA, and Puett, D. "The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake." Mol Cell Endocrinol 3, no. 1 (July 1975): 21-36.

PMID
168103
Scholars@Duke

Abe, K, Butcher, RW, Nicholson, WE, Baird, CE, Liddle, RA, and Liddle, GW. "Adenosine 3',5'-monophosphate (cyclic AMP) as the mediator of the actions of melanocyte stimulating hormone (MSH) and norepinephrine on the frog skin." Endocrinology 84, no. 2 (February 1969): 362-368.

PMID
4303528
Full Text

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