Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Liddle, RA. "Integrated actions of cholecystokinin on the gastrointestinal tract: use of the cholecystokinin bioassay." Gastroenterol Clin North Am 18, no. 4 (December 1989): 735-756. (Review)

PMID
2482253
Scholars@Duke

Smith, GP, Greenberg, D, Falasco, JD, Avilion, AA, Gibbs, J, Liddle, RA, and Williams, JA. "Endogenous cholecystokinin does not decrease food intake or gastric emptying in fasted rats." The American Journal of Physiology 257, no. 6 Pt 2 (December 1989): R1462-R1466.

PMID
2604005
Full Text

Liddle, RA, Gertz, BJ, Kanayama, S, Beccaria, L, Coker, LD, Turnbull, TA, and Morita, ET. "Effects of a novel cholecystokinin (CCK) receptor antagonist, MK-329, on gallbladder contraction and gastric emptying in humans. Implications for the physiology of CCK." The Journal of Clinical Investigation 84, no. 4 (October 1989): 1220-1225.

PMID
2794058
Full Text

Liddle, RA, Goldstein, RB, and Saxton, J. "Gallstone formation during weight-reduction dieting." Arch Intern Med 149, no. 8 (August 1989): 1750-1753.

PMID
2669662
Scholars@Duke

Miyasaka, K, Guan, DF, Liddle, RA, and Green, GM. "Feedback regulation by trypsin: evidence for intraluminal CCK-releasing peptide." The American Journal of Physiology 257, no. 2 Pt 1 (August 1989): G175-G181.

PMID
2764106
Full Text

Green, GM, Taguchi, S, Friestman, J, Chey, WY, and Liddle, RA. "Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat." The American Journal of Physiology 256, no. 6 Pt 1 (June 1989): G1016-G1021.

PMID
2735407
Full Text

Figlewicz, DP, Sipols, AJ, Porte, D, Woods, SC, and Liddle, RA. "Intraventricular CCK inhibits food intake and gastric emptying in baboons." The American Journal of Physiology 256, no. 6 Pt 2 (June 1989): R1313-R1317.

PMID
2735457
Full Text

LIDDLE, RA, GERTZ, BJ, KANAYAMA, S, BECCARIA, L, GETTYS, TW, TAYLOR, IL, RUSHAKOFF, RJ, WILLIAMS, VC, and COKER, LD. "EFFECT OF A NOVEL CHOLECYSTOKININ RECEPTOR ANTAGONIST, MK-329, ON PANCREATIC ENDOCRINE FUNCTION - IMPLICATIONS FOR THE PHYSIOLOGIC ROLE OF CCK." CLINICAL RESEARCH 37, no. 2 (April 1989): A369-A369.

Scholars@Duke

Putnam, WS, Liddle, RA, and Williams, JA. "Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide." The American Journal of Physiology 256, no. 4 Pt 1 (April 1989): G698-G703.

PMID
2565088
Full Text

Rosewicz, S, Lewis, LD, Wang, XY, Liddle, RA, and Logsdon, CD. "Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor." The American Journal of Physiology 256, no. 4 Pt 1 (April 1989): G733-G738.

PMID
2468294
Full Text

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