Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

Visit our lab page.

Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Bohórquez, DV, and Liddle, RA. "Axon-like basal processes in enteroendocrine cells: characteristics and potential targets." Clin Transl Sci 4, no. 5 (October 2011): 387-391. (Review)

PMID
22029814
Full Text

Chandra, R, and Liddle, RA. "Recent advances in pancreatic endocrine and exocrine secretion." Curr Opin Gastroenterol 27, no. 5 (September 2011): 439-443. (Review)

PMID
21778879
Full Text

Vigna, SR, Shahid, RA, Nathan, JD, McVey, DC, and Liddle, RA. "Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats." Pancreas 40, no. 5 (July 2011): 708-714.

PMID
21602738
Full Text

Wang, Y, Chandra, R, Samsa, LA, Gooch, B, Fee, BE, Cook, JM, Vigna, SR, Grant, AO, and Liddle, RA. "Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor." Am J Physiol Gastrointest Liver Physiol 300, no. 4 (April 2011): G528-G537.

PMID
21183662
Full Text

Bohorquez, DV, Samsa, LA, Vigna, SR, and Liddle, RA. "The enteroendocrine PYY cell interacts with neurites of the enteric nervous system through axon-like basal process." April 2011.

Scholars@Duke

Bohórquez, DV, Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Characterization of basal pseudopod-like processes in ileal and colonic PYY cells." J Mol Histol 42, no. 1 (February 2011): 3-13.

PMID
21061049
Full Text

Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Pseudopod-like basal cell processes in intestinal cholecystokinin cells." Cell Tissue Res 341, no. 2 (August 2010): 289-297.

PMID
20582553
Full Text

Romac, JM-J, Ohmuraya, M, Bittner, C, Majeed, MF, Vigna, SR, Que, J, Fee, BE, Wartmann, T, Yamamura, K-I, and Liddle, RA. "Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype." Am J Physiol Gastrointest Liver Physiol 298, no. 4 (April 2010): G518-G524.

PMID
20110462
Full Text

Nathan, JD, Romac, J, Peng, RY, Peyton, M, Rockey, DC, and Liddle, RA. "Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor." Pancreas 39, no. 1 (January 2010): e24-e30.

PMID
19904222
Full Text

Liddle, RA. "Pancreatitis: The acid test." Gastroenterology 139, no. 5 (2010): 1457-1460.

PMID
20875788
Full Text

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