Rodger Alan Liddle, MD

Professor of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.


Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California, San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California, San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California, San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972


Bohorquez, Diego V., Steven R. Vigna, and Rodger A. Liddle. “PYY-Secreting L Cells Connect to Enteric Myofibroblasts and Neurites Through Axon-Like Basal Processes.” In Gastroenterology, 140:S148–S148. W B SAUNDERS CO-ELSEVIER INC, 2011.


Bohorquez, Diego V., Leigh Ann Samsa, Steven R. Vigna, and Rodger A. Liddle. “The enteroendocrine PYY cell interacts with neurites of the enteric nervous system through axon-like basal process.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.


Wang, Yu, Rashmi Chandra, Leigh Ann Samsa, Barry Gooch, Brian E. Fee, J Michael Cook, Steven R. Vigna, Augustus O. Grant, and Rodger A. Liddle. “Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor..” Am J Physiol Gastrointest Liver Physiol 300, no. 4 (April 2011): G528–37.

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Bohórquez, Diego V., Rashmi Chandra, Leigh Ann Samsa, Steven R. Vigna, and Rodger A. Liddle. “Characterization of basal pseudopod-like processes in ileal and colonic PYY cells..” J Mol Histol 42, no. 1 (February 2011): 3–13.

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Chandra, Rashmi, Leigh Ann Samsa, Steven R. Vigna, and Rodger A. Liddle. “Pseudopod-like basal cell processes in intestinal cholecystokinin cells..” Cell Tissue Res 341, no. 2 (August 2010): 289–97.

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Romac, Joelle M-J, Masaki Ohmuraya, Cathy Bittner, M Faraz Majeed, Steven R. Vigna, Jianwen Que, Brian E. Fee, Thomas Wartmann, Ken-ichi Yamamura, and Rodger A. Liddle. “Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype..” Am J Physiol Gastrointest Liver Physiol 298, no. 4 (April 2010): G518–24.

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Nathan, Jaimie D., Joelle Romac, Ruth Y. Peng, Michael Peyton, Don C. Rockey, and Rodger A. Liddle. “Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor..” Pancreas 39, no. 1 (January 2010): e24–30.

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