Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.


Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972


Wang, Y, Chandra, R, Samsa, LA, Gooch, B, Fee, BE, Cook, JM, Vigna, SR, Grant, AO, and Liddle, RA. "Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor." American Journal of Physiology. Gastrointestinal and Liver Physiology 300, no. 4 (April 2011): G528-G537.

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Bohorquez, DV, Samsa, LA, Vigna, SR, and Liddle, RA. "The enteroendocrine PYY cell interacts with neurites of the enteric nervous system through axon-like basal process." April 2011.


Bohórquez, DV, Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Characterization of basal pseudopod-like processes in ileal and colonic PYY cells." Journal of Molecular Histology 42, no. 1 (February 2011): 3-13.

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Liddle, RA. "Pancreatitis: the acid test." Gastroenterology 139, no. 5 (November 2010): 1457-1460.

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Chandra, R, Samsa, LA, Vigna, SR, and Liddle, RA. "Pseudopod-like basal cell processes in intestinal cholecystokinin cells." Cell and Tissue Research 341, no. 2 (August 2010): 289-297.

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Romac, JM-J, Ohmuraya, M, Bittner, C, Majeed, MF, Vigna, SR, Que, J, Fee, BE, Wartmann, T, Yamamura, K-I, and Liddle, RA. "Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype." American Journal of Physiology. Gastrointestinal and Liver Physiology 298, no. 4 (April 2010): G518-G524.

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Nathan, JD, Romac, J, Peng, RY, Peyton, M, Rockey, DC, and Liddle, RA. "Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor." Pancreas 39, no. 1 (January 2010): e24-e30.

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Jr, RJR, and Liddle, RA. "A Tribute to Gary M. Green (1940-2008) IN MEMORIAM." PANCREAS 38, no. 7 (October 2009): 719-720.

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Chandra, R, and Liddle, RA. "Neural and hormonal regulation of pancreatic secretion." Current Opinion in Gastroenterology 25, no. 5 (September 2009): 441-446. (Review)

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Noble, MD, Romac, J, Vigna, SR, and Liddle, RA. "A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis." Gut 57, no. 11 (November 2008): 1566-1571.

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