Rodger Alan Liddle, MD

Professor of Medicine
Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Campus mail 1033A GSRB-1 Bldg, Durham, NC 27710
Phone (919) 681-6380
Email address rodger.liddle@duke.edu

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education and Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco, 1981 - 1984
  • Residency, Generalinternal Medicine, University of California - San Francisco, 1979 - 1981
  • Internship, General Internal Medicine, University of California - San Francisco, 1978 - 1979
  • M.D., Vanderbilt University, 1978
  • B.S., University of Utah, 1972

Publications

Liddle, RA. "Not for the faint of heart." Gastroenterology 129, no. 5 (November 2005): 1373-null.

PMID
16285936
Full Text

Noble, MD, and Liddle, RA. "Neurohormonal control of exocrine pancreatic secretion." Curr Opin Gastroenterol 21, no. 5 (September 2005): 531-537. (Review)

PMID
16093766
Scholars@Duke

Nathan, JD, Romac, J, Peng, RY, Peyton, M, Macdonald, RJ, and Liddle, RA. "Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice." Gastroenterology 128, no. 3 (March 2005): 717-727.

PMID
15765407
Full Text

McVey, DC, Liddle, RA, Riggs-Sauthier, J, Ekwuribe, N, and Vigna, SR. "Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA." Dig Dis Sci 50, no. 3 (March 2005): 565-573.

PMID
15810644
Scholars@Duke

Liddle, RA. "Comment from the Editors." Gastroenterology 129, no. 5 (2005): 1373--.

Full Text

Liddle, RA. "Susceptibility to pancreatitis related to PSTI/SPINK1 expression." Gastroenterology Clinics of North America 33, no. 4 (December 2004): 807-816. (Review)

PMID
15528019
Full Text

Liddle, RA. "A unifying principle in training gastroenterologists." Gastroenterology 127, no. 2 (August 2004): 377-null.

PMID
15300566
Full Text

Anderson, AML, Varkey, JB, Petti, CA, Liddle, RA, Frothingham, R, and Woods, CW. "Non-O1 Vibrio cholerae septicemia: case report, discussion of literature, and relevance to bioterrorism." Diagn Microbiol Infect Dis 49, no. 4 (August 2004): 295-297.

PMID
15313536
Full Text

Reeve, JR, Liddle, RA, McVey, DC, Vigna, SR, Solomon, TE, Keire, DA, Rosenquist, G, Shively, JE, Lee, TD, Chew, P, Green, GM, and Coskun, T. "Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological properties." American Journal of Physiology. Gastrointestinal and Liver Physiology 287, no. 2 (August 2004): G326-G333.

PMID
15064233
Full Text

Tashiro, M, Samuelson, LC, Liddle, RA, and Williams, JA. "Calcineurin mediates pancreatic growth in protease inhibitor-treated mice." American Journal of Physiology. Gastrointestinal and Liver Physiology 286, no. 5 (May 2004): G784-G790.

PMID
14684381
Full Text

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