Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@mc.duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebannon), 1993

Publications

Anderson, Mark E., Sana M. Al-Khatib, Dan M. Roden, Robert M. Califf, and Robert M. Duke Clinical Research Institute/American Heart Journal Expert Meeting on Repolarization Changes. “Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management..” Am Heart J 144, no. 5 (November 2002): 769–81. https://doi.org/10.1067/mhj.2002.125804.

PMID
12422144
Full Text

Al-Khatib, Sana M., Christopher B. Granger, Yao Huang, Kerry L. Lee, Robert M. Califf, Maarten L. Simoons, Paul W. Armstrong, et al. “Sustained ventricular arrhythmias among patients with acute coronary syndromes with no ST-segment elevation: incidence, predictors, and outcomes..” Circulation 106, no. 3 (July 16, 2002): 309–12. https://doi.org/10.1161/01.cir.0000022692.49934.e3.

PMID
12119245
Full Text

LaPointe, N. M. A., S. M. Al-Khatib, J. M. Kramer, J. Battle, and R. M. Califf. “Deficits in knowledge related to the QT interval that could impact patient safety.” Journal of the American College of Cardiology 39, no. 5 (March 6, 2002): 125A-125A.

Scholars@Duke

Al-Khatib, S. M. N., R. M. Califf, V. Hasselblad, J. H. Alexander, D. C. McCrory, and J. Sugarman. “Short-term trials and long-term effects - Response.” Science 293, no. 5539 (September 28, 2001): 2393–94.

Scholars@Duke

Al-Khatib, S. M., K. S. Pieper, K. L. Lee, K. W. Mahaffey, J. S. Hochman, C. J. Pepine, S. L. Kopecky, et al. “Atrial fibrillation and mortality among patients with acute coronary syndromes without ST-segment elevation: results from the PURSUIT trial..” Am J Cardiol 88, no. 1 (July 1, 2001): A7-79. https://doi.org/10.1016/s0002-9149(01)01593-4.

PMID
11423065
Full Text

Al-Khatib, S. M., R. M. Califf, V. Hasselblad, J. H. Alexander, D. C. McCrory, and J. Sugarman. “Medicine. Placebo-controls in short-term clinical trials of hypertension..” Science 292, no. 5524 (June 15, 2001): 2013–15. https://doi.org/10.1126/science.1057783.

PMID
11408643
Full Text

Al-Khatib, S. M., E. M. Ohman, H. D. White, C. B. Granger, R. M. Califf, R. Kilaru, and E. J. Topol. “Atrioventricular nodal block in acute myocardial infarction treated with thrombolytic therapy is common and portends poor prognosis: Results from large trials of thrombolytic therapy.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 341S-341S.

Scholars@Duke

Yamada, D. M., S. M. Al-Khatib, E. M. Ohman, and E. J. Topol. “Effect of anti arrhythmic treatment for sustained ventricular tachycardia in the setting of acute myocardial infarction.” Journal of the American College of Cardiology 37, no. 2 (February 1, 2001): 357A-357A.

Scholars@Duke

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