Sana Mustapha Al-Khatib, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7521 N Pavilion Bldg, Durham, NC 27715
Phone (919) 668-8649
Email address alkha001@duke.edu

Dr. Sana M. Al-Khatib is a tenured Professor of Medicine at Duke University Medical Center, a board-certified clinical electrophysiologist and an experienced clinical researcher in cardiac arrhythmias.  As a graduate of the NIH-funded Clinical Research Training Program, she is one of a few electrophysiologists nationwide with expertise in quantitative research methods. Her clinical expertise is in sudden cardiac death prevention, atrial fibrillation and ventricular arrhythmias, and implantable cardiac devices. Her research expertise lies in the design and conduct of clinical trials, outcomes research, and cost-effectiveness analyses. She is a recipient of a National Heart, Lung and Blood Institute’s R-01 grant titled “Implantable Cardioverter Defibrillator Therapy in Patients with Heart Failure” (2009-2013) and of an American Heart Association Career Development Award (2002-2006). She is a Co-Principal Investigator on an NHLBI-funded T-32 Postdoctoral Training in Cardiovascular Clinical Research and on several Agency of Healthcare Research and Quality sponsored R-01 grants including the “Duke Cardiovascular Center for Education and Research on Therapeutics.” She has more than 130 publications in peer-reviewed journals. She has established several collaborative research efforts both within and outside her institution. The goals of these collaborations are to synergize efforts aimed at improving the survival and quality of life of patients at risk for sudden cardiac death and those with atrial and ventricular arrhythmias through clinical trials and outcomes-based research and to evaluate study design and data analysis in order to improve the quality of research done in these arenas. Dr. Al-Khatib is an Associate Editor for the American Heart Journal and is on the Editorial Board for the Journal of Cardiovascular Electrophysiology. Dr. Al-Khatib serves on multiple national committees including the Heart Rhythm Society Board of Trustees, the Heart Rhythm Society Health Policy committee, the Heart Rhythm Society Legislative subcommittee, the Heart Rhythm Society Program Planning committee, the American College of Cardiology ICD Registry Steering committee, and the National Quality Forum Cardiovascular Steering committee.

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., American University of Beirut (Lebanon), 1993

Publications

Piccini, Jonathan P., John R. Horton, Linda K. Shaw, Sana M. Al-Khatib, Kerry L. Lee, Ami E. Iskandrian, and Salvador Borges-Neto. “Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death.” Circ Cardiovasc Imaging 1, no. 3 (November 2008): 180–88. https://doi.org/10.1161/CIRCIMAGING.108.776484.

PMID
19808541
Full Text

Whellan, David J., Sana M. Al-Khatib, Esteban Martin Kloosterman, Steven P. Kutalek, Anastasios Manaris, Christopher O’Connor, Behzad B. Pavri, et al. “Changes in Intrathoracic Fluid Index predict subsequent adverse events: Results of the Multi-site Program to Access and Review Trending INformation and Evaluate CoRrelation to Symptoms in Patients with Heart Failure (PARTNERS HF) Trial.” In Journal of Cardiac Failure, 14:799–799. Elsevier BV, 2008. https://doi.org/10.1016/j.cardfail.2008.10.015.

Full Text

Sanders, Gillian O., Melissa Kong, Sana M. Al-Khatib, and Eric D. Peterson. “Cost-Effectiveness of the Implantable Cardioverter Defibrillator in the Elderly.” Circulation 118, no. 18 (October 28, 2008): S1118–S1118.

Scholars@Duke

Al-Khatib, Sana M., Melissa A. Greiner, Eric D. Peterson, Adrian F. Hernandez, Kevin A. Schulman, and Lesley H. Curtis. “Patient and implanting physician factors associated with mortality and complications after implantable cardioverter-defibrillator implantation, 2002-2005.” Circ Arrhythm Electrophysiol 1, no. 4 (October 2008): 240–49. https://doi.org/10.1161/CIRCEP.108.777888.

PMID
19169382
Full Text

Al-Khatib, Sana M., Anne S. Hellkamp, Kerry L. Lee, Jill Anderson, Jeanne E. Poole, Daniel B. Mark, Gust H. Bardy, and Gust H. scd-heft investigators. “Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).” J Cardiovasc Electrophysiol 19, no. 10 (October 2008): 1059–65. https://doi.org/10.1111/j.1540-8167.2008.01191.x.

PMID
18479330
Full Text

Al-Khatib, Sana M., Gillian D. Sanders, Mark Carlson, Aida Cicic, Anne Curtis, Gregg C. Fonarow, Peter W. Groeneveld, et al. “Preventing tomorrow's sudden cardiac death today: dissemination of effective therapies for sudden cardiac death prevention.” Am Heart J 156, no. 4 (October 2008): 613–22. https://doi.org/10.1016/j.ahj.2008.05.027.

PMID
18926144
Full Text

Majidi, Mohamed, Andrzej S. Kosinski, Sana M. Al-Khatib, Miguel E. Lemmert, Lilian Smolders, Anton van Weert, Johan H. C. Reiber, et al. “Reperfusion ventricular arrhythmia 'bursts' in TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction: a more precise definition of reperfusion arrhythmias.” Europace 10, no. 8 (August 2008): 988–97. https://doi.org/10.1093/europace/eun123.

PMID
18483000
Full Text

Lopes, R. D., K. S. Pieper, J. R. Horton, S. M. Al-Khatib, L. K. Newby, R. H. Mehta, F. Van de Werf, et al. “Short- and long-term outcomes following atrial fibrillation in patients with acute coronary syndromes with or without ST-segment elevation.” Heart 94, no. 7 (July 2008): 867–73. https://doi.org/10.1136/hrt.2007.134486.

PMID
18332062
Full Text

Shah, Bimal, Adrian F. Hernandez, Li Liang, Sana M. Al-Khatib, Clyde Yancy, Gregg C. Fonarow, and Eric D. Peterson. “Hospital variation and characteristics of ICD implantation in eligible patients with heart failure: Data from the GWTG-HF registry.” In Circulation, 117:E443–E443. LIPPINCOTT WILLIAMS & WILKINS, 2008.

Scholars@Duke

Allen Lapointe, Nancy M., Jie-Lena Sun, Sigal Kaplan, Phil d’Almada, and Sana M. Al-Khatib. “Rhythm versus rate control in the contemporary management of atrial fibrillation in-hospital.” Am J Cardiol 101, no. 8 (April 15, 2008): 1134–41. https://doi.org/10.1016/j.amjcard.2007.11.067.

PMID
18394447
Full Text

Pages