Scott Michael Palmer, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Vice-Chair for Research in the Department of Medicine
Professor in Immunology
Professor in Population Health Sciences
Core Faculty in Innovation & Entrepreneurship
Campus mail 2085 Msrb2 2 Genome Ct, Durham, NC 27710
Phone (919) 684-0245
Email address scott.palmer@duke.edu

Dr. Palmer leads a successful program of clinical, basic and translational research in transplantation and advanced lung diseases. He currently directs the pulmonary research program at the Duke Clinical Research Institute (DCRI) and serves as Vice Chair for Research in the Department of Medicine.

Dr. Palmer has over 150 peer reviewed publications, received numerous awards, including election into the American Society for Clinical Investigation (ASCI) in 2012, chaired many sessions at national and international meetings, serves regularly on NIH study sections, and is on the editorial board of many prominent journals. He is also Associate Director of the Clinical Research Training Program at Duke and has personally mentored over 40 pre-and post-doctoral trainees, many of whom are now engaged in their own successful research careers.

His scientific accomplishments include the first human studies to demonstrate the importance of innate immunity in transplant rejection and completion of a prospective multicenter study that improved CMV prevention after lung transplantation.

Current basic projects in the lab are studying the role of the matrix in the activation of innate immunity in pulmonary transplant rejection, and epithelial injury and repair in the development of toxin induced bronchiolitis obliterans. Translational and human projects are studying predictors of lung transplant survival in the UNOS database, immune monitoring to predict CMV infection and acute rejection after lung transplantation, and the use of novel inhaled antibiotics in lung transplantation. The lab is also using cutting edge whole exome genetic sequencing to identify genetic predictors of transplant rejection.

Dr. Palmer also leads trials coordinated through the DCRI that study the natural history and investigate new treatments for idiopathic pulmonary fibrosis (IPF), chronic lung transplant rejection, and posttransplant cytomegalovirus infection.

Education and Training

  • Fellow, Pulmonary Medicine, Medicine, Duke University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.H.S., Duke University, 2000
  • M.D., Duke University, 1993

Publications

Todd, Jamie L., Megan L. Neely, Heather Kopetskie, Michelle L. Sever, Jerry Kirchner, Courtney W. Frankel, Laurie D. Snyder, et al. “Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.” Am J Respir Crit Care Med 202, no. 4 (August 15, 2020): 576–85. https://doi.org/10.1164/rccm.201910-1915OC.

PMID
32379979
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Gohir, Wajiha, William Klement, Lianne G. Singer, Scott M. Palmer, Tony Mazzulli, Shaf Keshavjee, and Shahid Husain. “Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus.” J Heart Lung Transplant, July 25, 2020. https://doi.org/10.1016/j.healun.2020.07.014.

PMID
32771440
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Fan, Yanni, Shaun D. Bender, Craig S. Conoscenti, Linda Davidson-Ray, Patricia A. Cowper, Scott M. Palmer, Joao A. de Andrade, and Joao A. IPF-PRO Registry Investigators. “Hospital-Based Resource Use and Costs Among Patients With Idiopathic Pulmonary Fibrosis Enrolled in the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.” Chest 157, no. 6 (June 2020): 1522–30. https://doi.org/10.1016/j.chest.2019.12.041.

PMID
32004554
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Case, Amy Hajari, Anne S. Hellkamp, Megan L. Neely, Shaun Bender, Daniel F. Dilling, Mridu Gulati, David L. Hotchkin, et al. “Associations between Patient-reported Outcomes and Death or Lung Transplant in Idiopathic Pulmonary Fibrosis. Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry.” Ann Am Thorac Soc 17, no. 6 (June 2020): 699–705. https://doi.org/10.1513/AnnalsATS.201906-437OC.

PMID
32040340
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Snyder, Laurie D., John Belperio, Marie Budev, Courtney Frankel, Jerry Kirchner, Tereza Martinu, Megan L. Neely, et al. “Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.” Am J Transplant 20, no. 6 (June 2020): 1489–94. https://doi.org/10.1111/ajt.15957.

PMID
32342596
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Rozenberg, D., L. G. Singer, M. L. Neely, J. M. Weber, H. A. Kopetskie, M. L. Sever, J. Kirchner, et al. “Agreement between Fried Frailty Phenotype and Cumulative Deficits Frailty Indices: A Prospective Multi-Center Study.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S314, 2020. https://doi.org/10.1016/j.healun.2020.01.707.

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Frankel, C. W., H. Kopetskie, M. Sever, M. Cosgrove, J. Kirchner, M. Robien, N. Williams, et al. “Prospective Assessment of Chronic Lung Allograft Dysfunction (CLAD); the Clinical Trials in Organ Transplantation (CTOT) Study Experience.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S303, 2020. https://doi.org/10.1016/j.healun.2020.01.677.

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Cherikh, W. S., B. J. Plucinski, S. Palmer, and W. E. Fitzsimmons. “Association of Discharge Immunosuppression Regimen and Post-Transplant Outcomes in Lung Transplantation: An Analysis of OPTN Data.” The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation 39, no. 4 (April 1, 2020): S126. https://doi.org/10.1016/j.healun.2020.01.1018.

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Todd, J. L., F. L. Kelly, M. L. Neely, K. Keslar, E. N. Pavlisko, S. J. McCall, A. Fletcher, et al. “NanoString Gene Expression Profiling in Chronic Lung Allograft Dysfunction (CLAD).” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S113, 2020. https://doi.org/10.1016/j.healun.2020.01.985.

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Cantu, E., C. Bermudez, M. Cevasco, Y. Suzuki, T. Buckley, V. Galati, N. Majeti, et al. “Implications of ECMO Bridging and Salvage Strategies on Mortality and PGD.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S103–4, 2020. https://doi.org/10.1016/j.healun.2020.01.960.

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