Seungkirl Ahn, PhD

Publications

Weiss, DR, Ahn, S, Sassano, MF, Kruse, AC, Karpiak, J, Roth, BL, Kobilka, BK, Shoichet, BK, and Lefkowitz, RJ. "G-protein coupled receptors in virtual screening: Functional fidelity and selectivity." April 7, 2013.

Scholars@Duke

Jiangbo, W, Ahn, S, Kahsai, AW, Rong, L, Jie, R, Kun, H, Xiaoqing, S, and Xin, C. "Synthesis of beta(2)-AR Agonist BI-167107." CHINESE JOURNAL OF ORGANIC CHEMISTRY 33, no. 3 (March 2013): 634-639.

Full Text

Heitzler, D, Durand, G, Gallay, N, Rizk, A, Ahn, S, Kim, J, Violin, JD, Dupuy, L, Gauthier, C, Piketty, V, Crépieux, P, Poupon, A, Clément, F, Fages, F, Lefkowitz, RJ, and Reiter, E. "Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. (Published online)" Mol Syst Biol 8 (June 26, 2012): 590-.

PMID
22735336
Full Text

Reiter, E, Ahn, S, Shukla, AK, and Lefkowitz, RJ. "Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors." Annual Review of Pharmacology and Toxicology 52 (January 2012): 179-197. (Review)

PMID
21942629
Full Text

Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Molecular Pharmacology 80, no. 3 (September 2011): 367-377.

PMID
21610196
Full Text

Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor." Nature Chemical Biology 7, no. 10 (August 21, 2011): 692-700.

PMID
21857662
Full Text

Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1." Nature 477, no. 7364 (August 21, 2011): 349-353.

PMID
21857681
Full Text

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Science Signaling 4, no. 185 (August 2011): ra51-null.

PMID
21868357
Full Text

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Shenoy, SK, Liedtke, W, and Lefkowitz, RJ. "Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4." The Journal of Biological Chemistry 285, no. 39 (September 2010): 30115-30125.

PMID
20650893
Full Text

Rajagopal, S, Kim, J, Ahn, S, Craig, S, Lam, CM, Gerard, NP, Gerard, C, and Lefkowitz, RJ. "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7." Proceedings of the National Academy of Sciences of the United States of America 107, no. 2 (January 2010): 628-632.

PMID
20018651
Full Text

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