Seungkirl Ahn, PhD

Publications

Aristotelous, T, Ahn, S, Shukla, AK, Gawron, S, Sassano, MF, Kahsai, AW, Wingler, LM, Zhu, X, Tripathi-Shukla, P, Huang, X-P, Riley, J, Besnard, J, Read, KD, Roth, BL, Gilbert, IH, Hopkins, AL, Lefkowitz, RJ, and Navratilova, I. "Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor." Acs Medicinal Chemistry Letters 4, no. 10 (October 2013): 1005-1010.

PMID
24454993
Full Text

Weiss, DR, Ahn, S, Sassano, MF, Kleist, A, Zhu, X, Strachan, R, Roth, BL, Lefkowitz, RJ, and Shoichet, BK. "Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor." Acs Chemical Biology 8, no. 5 (May 2013): 1018-1026.

PMID
23485065
Full Text

Weiss, DR, Ahn, S, Sassano, MF, Kruse, AC, Karpiak, J, Roth, BL, Kobilka, BK, Shoichet, BK, and Lefkowitz, RJ. "G-protein coupled receptors in virtual screening: Functional fidelity and selectivity." April 7, 2013.

Scholars@Duke

Jiangbo, W, Ahn, S, Kahsai, AW, Rong, L, Jie, R, Kun, H, Xiaoqing, S, and Xin, C. "Synthesis of beta(2)-AR Agonist BI-167107." CHINESE JOURNAL OF ORGANIC CHEMISTRY 33, no. 3 (March 2013): 634-639.

Full Text

Heitzler, D, Durand, G, Gallay, N, Rizk, A, Ahn, S, Kim, J, Violin, JD, Dupuy, L, Gauthier, C, Piketty, V, Crépieux, P, Poupon, A, Clément, F, Fages, F, Lefkowitz, RJ, and Reiter, E. "Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling." Molecular Systems Biology 8 (June 26, 2012): 590-null.

PMID
22735336
Full Text

Reiter, E, Ahn, S, Shukla, AK, and Lefkowitz, RJ. "Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors." Annual Review of Pharmacology and Toxicology 52 (January 2012): 179-197. (Review)

PMID
21942629
Full Text

Rajagopal, S, Ahn, S, Rominger, DH, Gowen-MacDonald, W, Lam, CM, Dewire, SM, Violin, JD, and Lefkowitz, RJ. "Quantifying ligand bias at seven-transmembrane receptors." Molecular Pharmacology 80, no. 3 (September 2011): 367-377.

PMID
21610196
Full Text

Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor." Nature Chemical Biology 7, no. 10 (August 21, 2011): 692-700.

PMID
21857662
Full Text

Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1." Nature 477, no. 7364 (August 21, 2011): 349-353.

PMID
21857681
Full Text

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Science Signaling 4, no. 185 (August 2011): ra51-null.

PMID
21868357
Full Text

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