Seungkirl Ahn, PhD

Publications

Meng, Kaicheng, Paul Shim, Qingtin Wang, Shuai Zhao, Ting Gu, Alem W. Kahsai, Seungkirl Ahn, and Xin Chen. “Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor.” Bioorg Med Chem 26, no. 9 (May 15, 2018): 2320–30. https://doi.org/10.1016/j.bmc.2018.03.023.

PMID
29588128
Full Text

Liu, Xiangyu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, et al. “Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.” Nature 548, no. 7668 (August 24, 2017): 480–84. https://doi.org/10.1038/nature23652.

PMID
28813418
Full Text

Ahn, Seungkirl, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L. Wall, Ryan T. Strachan, et al. “Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.” Proc Natl Acad Sci U S A 114, no. 7 (February 14, 2017): 1708–13. https://doi.org/10.1073/pnas.1620645114.

PMID
28130548
Full Text

Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.

PMID
27398998
Full Text

Staus, Dean P., Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, et al. “Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.” Nature 535, no. 7612 (July 21, 2016): 448–52. https://doi.org/10.1038/nature18636.

PMID
27409812
Full Text

Strachan, Ryan T., Jin-peng Sun, David H. Rominger, Jonathan D. Violin, Seungkirl Ahn, Alex Rojas Bie Thomsen, Xiao Zhu, Andrew Kleist, Tommaso Costa, and Robert J. Lefkowitz. “Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).” J Biol Chem 289, no. 20 (May 16, 2014): 14211–24. https://doi.org/10.1074/jbc.M114.548131.

PMID
24668815
Full Text

Staus, Dean P., Laura M. Wingler, Ryan T. Strachan, Soren G. F. Rasmussen, Els Pardon, Seungkirl Ahn, Jan Steyaert, Brian K. Kobilka, and Robert J. Lefkowitz. “Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.” Mol Pharmacol 85, no. 3 (March 2014): 472–81. https://doi.org/10.1124/mol.113.089516.

PMID
24319111
Full Text

Aristotelous, Tonia, Seungkirl Ahn, Arun K. Shukla, Sylwia Gawron, Maria F. Sassano, Alem W. Kahsai, Laura M. Wingler, et al. “Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.” Acs Med Chem Lett 4, no. 10 (October 10, 2013): 1005–10. https://doi.org/10.1021/ml400312j.

PMID
24454993
Full Text

Weiss, Dahlia R., SeungKirl Ahn, Maria F. Sassano, Andrew Kleist, Xiao Zhu, Ryan Strachan, Bryan L. Roth, Robert J. Lefkowitz, and Brian K. Shoichet. “Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.” Acs Chem Biol 8, no. 5 (May 17, 2013): 1018–26. https://doi.org/10.1021/cb400103f.

PMID
23485065
Full Text

Weiss, Dahlia R., SeungKirl Ahn, Maria F. Sassano, Andrew C. Kruse, Joel Karpiak, Bryan L. Roth, Brian K. Kobilka, Brian K. Shoichet, and Robert J. Lefkowitz. “G-protein coupled receptors in virtual screening: Functional fidelity and selectivity.” In Abstracts of Papers of the American Chemical Society, Vol. 245. AMER CHEMICAL SOC, 2013.

Scholars@Duke

Pages