Sin Tiong Ong, MBBCh

Associate Professor of Medicine
Campus mail 406 Seeley Mudd Bldg, Box 3406, Durham, NC 27710
Email address sintiong.ong@duke-nus.edu.sg

Education and Training

  • Resident, Medicine, University of California at Irvine, 1997 - 1999
  • Fellow, Hematology, Oncology, University of Chicago, 1993 - 1997
  • Resident, National University Hospital (Singapore), 1991 - 1993
  • M.B.B.Ch., University of Cambridge (UK), 1987

Publications

Ng, King-Pan, Tuang Yeow Poh, Wen Tian Sun, Charles Chuah, and S Tiong Ong. “Physiologic Hypoxia Protects Chronic Myelogenous Leukemia Progenitors From Elimination by Imatinib Mesylate.” In Blood, 114:858–858. AMER SOC HEMATOLOGY, 2009.

Scholars@Duke

Zhang, Min, Wuxia Fu, Sharmila Prabhu, James C. Moore, Je Ko, Jung Woo Kim, Brian J. Druker, et al. “Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance..” Mol Cell Biol 28, no. 20 (October 2008): 6496–6509. https://doi.org/10.1128/MCB.00477-08.

PMID
18694961
Full Text

Arechiga, Adrian F., Bryan D. Bell, Sabrina Leverrier, Brian M. Weist, Melissa Porter, Zhengqi Wu, Yuka Kanno, et al. “A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2..” J Immunol 179, no. 8 (October 15, 2007): 5291–5300. https://doi.org/10.4049/jimmunol.179.8.5291.

PMID
17911615
Full Text

Prabhu, S., D. Saadat, M. Zhang, L. Halbur, J. P. Fruehauf, and S. T. Ong. “A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation..” Oncogene 26, no. 8 (February 22, 2007): 1188–1200. https://doi.org/10.1038/sj.onc.1209901.

PMID
16936779
Full Text

Moore, James C., Carolyn F. Dennehey, Arash Anavim, Kevin M. Kong, and S. Tiong Ong. “Multiple joint effusions associated with high-dose imatinib therapy in a patient with chronic myelogenous leukaemia..” Eur J Haematol 76, no. 5 (May 2006): 444–46. https://doi.org/10.1111/j.1600-0609.2006.00649.x.

PMID
16548915
Full Text

Ly, Chi, Adrian F. Arechiga, Junia V. Melo, Craig M. Walsh, and S Tiong Ong. “Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin..” Cancer Res 63, no. 18 (September 15, 2003): 5716–22.

PMID
14522890
Scholars@Duke

Tiong Ong, S., Chi Ly, Mark Nguyen, B. Kay Brightman, and Hung Fan. “Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection..” Cell Immunol 221, no. 1 (January 2003): 64–79.

PMID
12742383
Scholars@Duke

Peters, U. R., U. Hasse, E. Oppliger, M. Tschan, S. T. Ong, F. V. Rassool, B. Borisch, A. Tobler, and M. F. Fey. “Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia..” Oncogene 18, no. 1 (January 7, 1999): 79–85. https://doi.org/10.1038/sj.onc.1202256.

PMID
9926922
Full Text

Ong, S. T., and M. M. Le Beau. “Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma..” Semin Oncol 25, no. 4 (August 1998): 447–60.

PMID
9728595
Scholars@Duke

Ong, S. T., M. L. Hackbarth, L. C. Degenstein, D. A. Baunoch, J. Anastasi, and T. W. McKeithan. “Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice..” Oncogene 16, no. 18 (May 7, 1998): 2333–43. https://doi.org/10.1038/sj.onc.1201771.

PMID
9620550
Full Text

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