Steve M Taylor, MD

Associate Professor of Medicine
Assistant Research Professor of Global Health
Campus mail 303 Research Drive, Sands Building #321a, Durham, NC 27710
Phone (919) 684-5815
Email address steve.taylor@duke.edu

My lab website has a fuller description of my research activities: https://sites.duke.edu/taylorlab/.

I am principally interested in field and translational studies of falciparum malaria. These interests fall along several lines:

1) Epidemiology. Falciparum malaria is an immense problem whose contours are difficult to discern in hyperendemic regions like much of sub-Saharan Africa. I am involved in field applications of molecular genetic techniques to better define the burden of parasitemia in endemic areas and the partitioning and flux of parasite populations. We are working on techniques to generate and parse high-dimensional genomic data to better understand the structure of these parasite populations. Ultimately the goal of these investigations is to inform measures to control malaria and contain distinct parasite populations.

2) Pathogenesis. Severe malaria is a lethal disease; it is the cause of most of the 400,000 malaria deaths annually in African children. In these children, sickle-trait hemoglobin confers >90% protection from severe, life-threatening malaria. Several lines of evidence support the hypothesis that this dramatic protection results from the inability of the parasite to export parasite-derived proteins to the surface of the infected human red blood cell. We are investigating the molecular genetic correlates of this phenomenon in in vitro and ex vivo systems in order to identify mechanisms by which sickle-trait neutralizes the parasite. By leveraging this naturally-occurring model of malaria protection we hope to ultimately identify druggable targets for future antiparasitic or adjunctive therapies.

3) Diagnostics. In the field, clinical practice guidelines now recommend parasitologic diagnosis of malaria prior to treatment. Parasite detection can be confirmed by traditional microscopy or by rapid immunochromatographic tests, but each of these approaches is potentially undermined by limits of detection, operator error, and the monoplex nature of parasite testing in settings with complex pathogen epidemiology. With collaborators in Biomedical Engineering at the Pratt School of Engineering, we are developing PCR-free multiplex detection assays that utilize robust, rapid, and scalable nanoengineered platforms that target multiple bloodborne tropical pathogens in a single assay. The ultimate goal of this project is to enhance the clinical management of febrile illness in the tropics.

4) Prevention. In malaria-endemic Africa, high-risk groups that suffer disproportionate malaria morbidity clearly benefit from antimalarial chemoprevention; these groups include pregnant women across Africa and children under 5 in West Africa. African children with sickle-cell anemia also suffer significant malaria morbidity, but chemoprevention regimens that are recommended for them lack a compelling evidence base. With partners in Malawi and Kenya, we are testing new approaches to malaria chemoprevention in both pregnant women and in children with sickle-cell anemia. The goal of these projects is to enhance public health guidelines for the routine care of these high-risk groups and reduce the burden of malaria in African children.

The ultimate goals of these translational studies of falciparum malaria in children and pregnant women is to integrate epidemiologic, clinical, and molecular genetic models of disease in order to inform the rational design of medical and public health interventions to reduce the awful burden of malaria.

Education and Training

  • Gillings School of Global Public Health - Postdoctoral Fellow, Department Of Epidemiology, University of North Carolina at Chapel Hill, 2008 - 2012
  • Fellowship, Infectious Diseases & International Health, Duke University School of Medicine, 2007 - 2012
  • Internship/Residency, Medicine, Yale University School of Medicine, 2004 - 2007
  • M.D., Duke University School of Medicine, 2004
  • M.P.H., University of North Carolina at Chapel Hill, 2003
  • B.S., Duke University, 1998

Publications

Antonia, Alejandro L., Steve M. Taylor, Mark Janko, Michael Emch, Antoinette K. Tshefu, and Steven R. Meshnick. “A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo..” Am J Trop Med Hyg 90, no. 6 (June 2014): 1094–97. https://doi.org/10.4269/ajtmh.13-0378.

PMID
24732459
Full Text

Patel, Jaymin C., Steve M. Taylor, Patricia C. Juliao, Christian M. Parobek, Mark Janko, Luis Demetrio Gonzalez, Lucia Ortiz, et al. “Genetic Evidence of Importation of Drug-Resistant Plasmodium falciparum to Guatemala from the Democratic Republic of the Congo..” Emerg Infect Dis 20, no. 6 (June 2014): 932–40. https://doi.org/10.3201/eid2006.131204.

PMID
24856348
Full Text

Parobek, Christian M., Linda Y. Jiang, Jaymin C. Patel, Miriam J. Alvarez-Martínez, Jose M. Miro, William Worodria, Alfred Andama, et al. “Multilocus microsatellite genotyping array for investigation of genetic epidemiology of Pneumocystis jirovecii..” J Clin Microbiol 52, no. 5 (May 2014): 1391–99. https://doi.org/10.1128/JCM.02531-13.

PMID
24523468
Full Text

Coulibaly, Sheick O., Kassoum Kayentao, Steve Taylor, Etienne A. Guirou, Carole Khairallah, Nouhoun Guindo, Moussa Djimde, et al. “Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study..” Malar J 13 (January 31, 2014). https://doi.org/10.1186/1475-2875-13-41.

PMID
24484467
Full Text

Taylor, Steve M., Christian M. Parobek, Nash Aragam, Billy E. Ngasala, Andreas Mårtensson, Steven R. Meshnick, and Jonathan J. Juliano. “Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes..” J Infect Dis 208, no. 12 (December 15, 2013): 1998–2006. https://doi.org/10.1093/infdis/jit392.

PMID
23908494
Full Text

Yoon, Christina, Anuradha Subramanian, Amy Chi, Kristina Crothers, Steven R. Meshnick, Steve M. Taylor, Charles B. Beard, et al. “Dihydropteroate synthase mutations in Pneumocystis pneumonia: impact of applying different definitions of prophylaxis, mortality endpoints and mutant in a single cohort..” Med Mycol 51, no. 6 (August 2013): 568–75. https://doi.org/10.3109/13693786.2013.770604.

PMID
23470037
Full Text

Lin, Jessica T., Bernard Mbewe, Steve M. Taylor, Mari Luntamo, Steven R. Meshnick, and Per Ashorn. “Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria..” Trop Med Int Health 18, no. 2 (February 2013): 175–78. https://doi.org/10.1111/tmi.12028.

PMID
23198734
Full Text

Taylor, Steve M., Alejandro L. Antonia, Christian M. Parobek, Jonathan J. Juliano, Mark Janko, Michael Emch, Md Tauqeer Alam, Venkatachalam Udhayakumar, Antoinette K. Tshefu, and Steven R. Meshnick. “Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo..” Sci Rep 3 (2013). https://doi.org/10.1038/srep01165.

PMID
23372922
Full Text

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