Steven Patierno, PhD

Professor of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Family Medicine and Community Health
Core Faculty Member, Duke-Margolis Center for Health Policy
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710
Phone (919) 613-5093
Email address steven.patierno@duke.edu

Patierno's current translational research interests are focused on the genomics molecular biology of cancer disparities, cancer biology, molecular pharmacology and targeted experimental therapeutics to control prostate, breast and lung tumor aggressiveness. He is an internationally recognized expert in cancer control, cancer causation and molecular carcinogenesis, which includes a broad spectrum of laboratory and population level research.   Patierno is also actively engaged in cancer health disparities and healthcare delivery research focused on patient navigation, survivorship, community-based interventions, mHealth, implementation sciences, cancer care economics, and policy.

Education and Training

  • Postdoctoral Training, Norris Comprehensive Cancer, University of Southern California, 1986 - 1988
  • Ph.D., University of Texas Medical School, Houston, 1985
  • B.S., University of Connecticut, 1981

Publications

Bianco, Fernando J., Benjamin R. McHone, Kristopher Wagner, Andre King, Jacqueline Burgess, Steve Patierno, and Thomas W. Jarrett. “Prevalence of erectile dysfunction in men screened for prostate cancer.” Urology 74, no. 1 (July 2009): 89–93. https://doi.org/10.1016/j.urology.2008.03.036.

PMID
19428072
Full Text

Lal, Madhu A., Dongsoon Bae, Tura C. Camilli, Steven R. Patierno, and Susan Ceryak. “AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.” Cell Cycle 8, no. 10 (May 15, 2009): 1589–1602. https://doi.org/10.4161/cc.8.10.8547.

PMID
19377290
Full Text

O’Brien, Travis J., Preston Witcher, Bradford Brooks, and Steven R. Patierno. “DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis.” Mutat Res 663, no. 1–2 (April 26, 2009): 77–83. https://doi.org/10.1016/j.mrfmmm.2009.01.012.

PMID
19428373
Full Text

Beaver, Laura M., Erik J. Stemmy, Stephanie L. Constant, Arnold Schwartz, Laura G. Little, Jason P. Gigley, Gina Chun, Kent D. Sugden, Susan M. Ceryak, and Steven R. Patierno. “Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium.” Toxicol Appl Pharmacol 235, no. 1 (February 15, 2009): 47–56. https://doi.org/10.1016/j.taap.2008.11.018.

PMID
19109987
Full Text

Bae, Dongsoon, Tura C. Camilli, Gina Chun, Madhu Lal, Kristen Wright, Travis J. O’Brien, Steven R. Patierno, and Susan Ceryak. “Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.” Mutat Res 660, no. 1–2 (January 15, 2009): 40–46. https://doi.org/10.1016/j.mrfmmm.2008.10.006.

PMID
19013184
Full Text

Freund, Karen M., Tracy A. Battaglia, Elizabeth Calhoun, Donald J. Dudley, Kevin Fiscella, Electra Paskett, Peter C. Raich, Richard G. Roetzheim, and Richard G. Patient Navigation Research Program Group. “National Cancer Institute Patient Navigation Research Program: methods, protocol, and measures.” Cancer 113, no. 12 (December 15, 2008): 3391–99. https://doi.org/10.1002/cncr.23960.

PMID
18951521
Full Text

Brooks, Bradford, Travis J. O’Brien, Susan Ceryak, John Pierce Wise, Sandra S. Wise, Edward Defabo, and Steven R. Patierno. “Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.” Carcinogenesis 29, no. 5 (May 2008): 1064–69. https://doi.org/10.1093/carcin/bgn058.

PMID
18332048
Full Text

Vilcheck, Susan K., Susan Ceryak, Travis J. O’Brien, and Steven R. Patierno. “FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs.” Mutat Res 610, no. 1–2 (November 7, 2006): 21–30. https://doi.org/10.1016/j.mrgentox.2006.06.009.

PMID
16893675
Full Text

O’Brien, Travis J., Guohui Jiang, Gina Chun, H George Mandel, Craig S. Westphal, Kaveh Kahen, Akbar Montaser, J Christopher States, and Steven R. Patierno. “Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease.” Mutat Res 610, no. 1–2 (November 7, 2006): 85–92. https://doi.org/10.1016/j.mrgentox.2006.06.015.

PMID
16890479
Full Text

O’Brien, Travis J., H George Mandel, Kent D. Sugden, Andrei M. Komarov, and Steven R. Patierno. “Hypoxia impedes the formation of chromium DNA-adducts in a cell-free system.” Biochem Pharmacol 70, no. 12 (December 5, 2005): 1814–22. https://doi.org/10.1016/j.bcp.2005.09.016.

PMID
16242673
Full Text

Pages