Steven Patierno, PhD

Professor of Medicine
Professor of Pharmacology and Cancer Biology
Professor in Family Medicine and Community Health
Core Faculty Member, Duke-Margolis Center for Health Policy
Member of the Duke Cancer Institute
Campus mail 10 Bryan Searle Drive, Seeley Mudd Building, Suite 413, Durham, NC 27710
Phone (919) 613-5093
Email address steven.patierno@duke.edu

Patierno's current translational research interests are focused on the genomics molecular biology of cancer disparities, cancer biology, molecular pharmacology and targeted experimental therapeutics to control prostate, breast and lung tumor aggressiveness. He is an internationally recognized expert in cancer control, cancer causation and molecular carcinogenesis, which includes a broad spectrum of laboratory and population level research.   Patierno is also actively engaged in cancer health disparities and healthcare delivery research focused on patient navigation, survivorship, community-based interventions, mHealth, implementation sciences, cancer care economics, and policy.

Education and Training

  • Postdoctoral Training, Norris Comprehensive Cancer, University of Southern California, 1986 - 1988
  • Ph.D., University of Texas Medical School, Houston, 1985
  • B.S., University of Connecticut, 1981

Publications

Ceryak, Susan, Carla Zingariello, Travis O’Brien, and Steven R. Patierno. “Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK.” Mol Cell Biochem 255, no. 1–2 (January 2004): 139–49. https://doi.org/10.1023/b:mcbi.0000007270.82431.3e.

PMID
14971655
Full Text

Xu, Jian, Francis C. R. Manning, Travis J. O’Brien, Susan Ceryak, and Steven R. Patierno. “Mechanisms of chromium-induced suppression of RNA synthesis in cellular and cell-free systems: relationship to RNA polymerase arrest.” Mol Cell Biochem 255, no. 1–2 (January 2004): 151–60. https://doi.org/10.1023/b:mcbi.0000007271.53241.ae.

PMID
14971656
Full Text

O’Brien, Travis J., Susan Ceryak, and Steven R. Patierno. “Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms.” Mutat Res 533, no. 1–2 (December 10, 2003): 3–36. https://doi.org/10.1016/j.mrfmmm.2003.09.006.

PMID
14643411
Full Text

Ha, Linan, Susan Ceryak, and Steven R. Patierno. “Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.” J Biol Chem 278, no. 20 (May 16, 2003): 17885–94. https://doi.org/10.1074/jbc.M210560200.

PMID
12637545
Full Text

Rickles, Frederick R., Steven R. Patierno, and Patricia M. Fernandez. “Targeting the endothelium in cancer--the importance of the interaction of hemostatic mechanisms and the vascular wall for tumor growth and angiogenesis.” Pathophysiol Haemost Thromb 33 Suppl 1 (2003): 1–4. https://doi.org/10.1159/000073276.

PMID
12954987
Full Text

Lugassy, Claire, Raymond I. Haroun, Henry Brem, Betty M. Tyler, Robert V. Jones, Patricia M. Fernandez, Steven R. Patierno, Hynda K. Kleinman, and Raymond L. Barnhill. “Pericytic-like angiotropism of glioma and melanoma cells.” Am J Dermatopathol 24, no. 6 (December 2002): 473–78. https://doi.org/10.1097/00000372-200212000-00003.

PMID
12454598
Full Text

O’Brien, Travis, H George Mandel, Daryl E. Pritchard, and Steven R. Patierno. “Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.” Biochemistry 41, no. 41 (October 15, 2002): 12529–37. https://doi.org/10.1021/bi020452j.

PMID
12369844
Full Text

Vilcheck, Susan K., Travis J. O’Brien, Daryl E. Pritchard, Linan Ha, Susan Ceryak, Jamie L. Fornsaglio, and Steven R. Patierno. “Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.” Environ Health Perspect 110 Suppl 5 (October 2002): 773–77. https://doi.org/10.1289/ehp.02110s5773.

PMID
12426130
Full Text

Lugassy, Claire, Hynda K. Kleinman, Patricia M. Fernandez, Steven R. Patierno, Mukta M. Webber, Ghanem Ghanem, Alain Spatz, and Raymond L. Barnhill. “Human melanoma cell migration along capillary-like structures in vitro: a new dynamic model for studying extravascular migratory metastasis.” J Invest Dermatol 119, no. 3 (September 2002): 703–4. https://doi.org/10.1046/j.1523-1747.2002.01857.x.

PMID
12230517
Full Text

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