Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Vigna, SR. "Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis." Gastroenterology Research and Practice 2017 (January 2017): 8438172-.

PMID
28484490
Full Text

Vigna, SR. "Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats." International Journal of Inflammation 2016 (January 11, 2016): 4705065-.

PMID
26881175
Full Text

Shahid, RA, Wang, DQ-H, Fee, BE, McCall, SJ, Romac, JM-J, Vigna, SR, and Liddle, RA. "Endogenous elevation of plasma cholecystokinin does not prevent gallstones." European journal of clinical investigation 45, no. 3 (March 2015): 237-246.

PMID
25641074
Full Text

Shahid, RA, Vigna, SR, Layne, AC, Romac, JM-J, and Liddle, RA. "Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice." Cellular and molecular gastroenterology and hepatology 1, no. 1 (January 2015): 75-86.

PMID
25729765
Full Text

Shahid, RA, Davis, SJ, Vigna, SR, and Liddle, RA. "Bile Acid-Induced Acute Pancreatitis in Mice Is Caused by Acinar Cell Leukotriene B-4 Secretion Through a Calcium-Independent Pathway." May 2014.

Scholars@Duke

Vigna, SR, Shahid, RA, and Liddle, RA. "Ethanol contributes to neurogenic pancreatitis by activation of TRPV1." FASEB J 28, no. 2 (February 2014): 891-896.

PMID
24221085
Full Text

Vigna, SR. "5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats." International Journal of Inflammation 2014 (January 2014): 389621-.

PMID
25045574
Full Text

Chandra, R, Wang, Y, Shahid, RA, Vigna, SR, Freedman, NJ, and Liddle, RA. "Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion." J Clin Invest 123, no. 8 (August 2013): 3343-3352.

PMID
23863714
Full Text

Chandra, R, Wang, Y, Shahid, RA, Vigna, SR, Freedman, NJ, and Liddle, RA. "Immunoglobulin-Like Domain Containing Receptor Mediates Fat-Stimulated Cholecystokinin Secretion." May 2013.

Scholars@Duke

Shahid, RA, Vigna, SR, and Liddle, RA. "Leukotriene B-4 Activation of TRPV1 Mediates Acute Pancreatitis Induced by Pancreatic Duct Infusion of Sodium Taurocholate in Mice." May 2012.

Scholars@Duke

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