Steven R. Vigna, PhD

Associate Professor of Cell Biology
Associate Professor in Medicine
Campus mail Duke Box 103859, Durham, NC 27710
Phone (919) 684-8860
Email address steven.vigna@duke.edu

We are interested in the mechanisms of signal transduction of neuropeptides and peptide hormones, mechanisms of receptor regulation, and the role of receptor regulation in health and disease. The major peptide of interest is the neurotransmitter substance P which is involved in gastrointestinal tract regulation, pain pathways, inflammation, and central nervous system functions. Our major focus is at the level of the receptors for this peptide. We are currently studying mechanisms of substance P receptor desensitization, resensitization, and downregulation in model cell systems and using analysis of substance P-induced endocytosis of the substance P receptor to reveal mechanisms of pain transmission and inflammation in vivo in animal models. The approaches used to investigate questions of interest are pharmacological, cellular, biochemical, and molecular.

Education and Training

  • Ph.D., University of Washington, 1978
  • B.S., University of Washington, 1971

Publications

Romac, Joelle M-J, Rafiq A. Shahid, Sandip M. Swain, Steven R. Vigna, and Rodger A. Liddle. “Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis..” Nat Commun 9, no. 1 (April 30, 2018). https://doi.org/10.1038/s41467-018-04194-9.

PMID
29712913
Full Text

Vigna, Steven R. “Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis..” Gastroenterol Res Pract 2017 (2017). https://doi.org/10.1155/2017/8438172.

PMID
28484490
Full Text

Shahid, Rafiq A., David Q-H Wang, Brian E. Fee, Shannon J. McCall, Joelle M-J Romac, Steven R. Vigna, and Rodger A. Liddle. “Endogenous elevation of plasma cholecystokinin does not prevent gallstones..” Eur J Clin Invest 45, no. 3 (March 2015): 237–46. https://doi.org/10.1111/eci.12400.

PMID
25641074
Full Text

Shahid, Rafiq A., Steven R. Vigna, Amanda C. Layne, Joelle M-J Romac, and Rodger A. Liddle. “Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice..” Cell Mol Gastroenterol Hepatol 1, no. 1 (January 2015): 75–86. https://doi.org/10.1016/j.jcmgh.2014.11.002.

PMID
25729765
Full Text

Shahid, Rafiq A., Supriya J. Davis, Steven R. Vigna, and Rodger A. Liddle. “Bile Acid-Induced Acute Pancreatitis in Mice Is Caused by Acinar Cell Leukotriene B-4 Secretion Through a Calcium-Independent Pathway.” In Gastroenterology, 146:S297–S297. W B SAUNDERS CO-ELSEVIER INC, 2014.

Scholars@Duke

Vigna, Steven R., Rafiq A. Shahid, and Rodger A. Liddle. “Ethanol contributes to neurogenic pancreatitis by activation of TRPV1..” Faseb J 28, no. 2 (February 2014): 891–96. https://doi.org/10.1096/fj.13-236208.

PMID
24221085
Full Text

Chandra, Rashmi, Yu Wang, Rafiq A. Shahid, Steven R. Vigna, Neil J. Freedman, and Rodger A. Liddle. “Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion..” J Clin Invest 123, no. 8 (August 2013): 3343–52. https://doi.org/10.1172/JCI68587.

PMID
23863714
Full Text

Shahid, Rafiq A., Steven R. Vigna, and Rodger A. Liddle. “Bile Acid-Induced Acute Pancreatitis Is Mediated by Acinar Cell Leukotriene B-4 Secretion.” In Gastroenterology, 144:S320–S320. W B SAUNDERS CO-ELSEVIER INC, 2013.

Scholars@Duke

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